Caroline Baynard's research while affiliated with The Rockefeller University and other places

Publications (3)

Article
Full-text available
Background One of the most prominent opioid analgesics in the United States is the high potency agonist fentanyl. It is used in the treatment of acute and chronic pain and as an anesthetic adjuvant. When used inappropriately, however, ingestion of just a few milligrams of fentanyl or other synthetic opioid can cause opioid-induced respiratory depre...
Article
Full-text available
The kappa-opioid receptor (KOR) / dynorphin system is implicated with behavioral and neurobiological effects of stress exposure (including heavy exposure to drugs of abuse) in translational animal models. Thus some KOR-antagonists can decrease the aversive, depressant-like and anxiety-like effects caused by stress exposure. The first generation of...
Article
Background Novel short-acting κ(kappa)-opioid receptor selective antagonists are translational tools to examine the impact of the κ-receptor/dynorphin system in assays related to central nervous system dysfunction (e.g., substance use disorders, anhedonia and depression). The effects of such compounds have been compared in males and females under v...

Citations

... These studies (in C57BL/6J mice from the Jackson Laboratory) focused on the effectiveness of 29 in preventing decreases in locomotor activity caused by the KOR agonist U50,488 (10 mg/kg, IP) over 90 min. This dose and duration of monitoring period was based on recently published studies [36]. Mice were placed individually in rectangular transparent plastic cages (19.7 cm width × 41.3 cm length × 20.3 cm height) with bedding identical to that in the home cage. ...