Carolin Thomas's research while affiliated with ETH Zurich and other places
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Publications (4)
Age-associated diseases represent a growing burden for global health systems in our aging society. Consequently, we urgently need innovative strategies to counteract these pathological disturbances. Overwhelming generation of reactive oxygen species (ROS) is associated with age-related damage, leading to cellular dysfunction and, ultimately, diseas...
Aging is impacted by interventions across species, often converging on metabolic pathways. Transcription factors regulate longevity yet approaches for their pharmacological modulation to exert geroprotection remain sparse. We show that increased expression of the transcription factor Grainyhead 1 (GRH-1) promotes lifespan and pathogen resistance in...
Calcium (Ca²⁺) and reactive oxygen species (ROS) are versatile signaling molecules coordinating physiological and pathophysiological processes. While channels and pumps shuttle Ca²⁺ ions between extracellular space, cytosol and cellular compartments, short-lived and highly reactive ROS are constantly generated by various production sites within the...
Citations
... Accomplishing SOS demands comprehensive, integrated healthcare. Numerous frequently used drugs impact OS either directly or indirectly (183). This review analyzes many of these agents used to help manage CV risk through the lens of directly mitigating OS. ...
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... Overall the motifs point can be related to cell cycle regulation and are consistent with the interpretation of nTA hi as a marker for chromatin condensation. However, we expect that more information can be extracted, e.g., GRHL1 has also been linked to aging, although in an insulin related manner 22 . Per-cell nTAs are available on Github for further exploration. ...
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... Calcium (Ca 2+ ) storage in the ER plays a central role in pro-survival and cell death by regulating various intracellular signaling pathways [35]. In addition, excessive ROS and intracellular Ca 2+ release induces apoptosis in diverse cancers; thus, targeting ROS and Ca 2+ is a potential anti-cancer therapeutic strategy [36,37]. Moreover, accumulating reports suggest that ROS and Ca 2+ generation regulate cell death by inducing the ER stress signaling pathway [38]. ...
