Carmen Wheatley's scientific contributions

Publications (3)

Data
Background. NOS/ NO inhibitors are potential therapeutics for sepsis, yet they increase clinical mortality. However, there has been no in vivo investigation of the (in vitro) NO scavenger, cobalamin's (Cbl) endogenous eects on NOS/ NO/inammatory mediators during the immune response to sepsis. Methods. We used quantitative polymerase chain reaction...
Data
Background. NOS/ NO inhibitors are potential therapeutics for sepsis, yet they increase clinical mortality. However, there has been no in vivo investigation of the (in vitro) NO scavenger, cobalamin's (Cbl) endogenous eects on NOS/ NO/inammatory mediators during the immune response to sepsis. Methods. We used quantitative polymerase chain reaction...
Article
Cobalamin carrier proteins,the Transcobalamins (TCS), are elevated during trauma, infections and chronic inflammatory conditions. This remains un-explained. It is proposed that such TC elevations signal a need for cobalamin central to the resolution of inflammation. Thus Cobalamin may regulate the transcription factor, NFkappaB, activation or suppr...

Citations

... It is also well known the crucial involvement of different proinflammatory cytokines, including IL-1β, IL-12, IL-17, IL-6 and TNFα, in the pathogenesis of the acute and chronic phases of intestinal inflammation. They have been reported to be up-regulated in both human IBD and in experimental colitis, thus revealing the existence of an excessive activation of the adaptive immunity, which is affected by a combination of resident and recruited cell populations (Sampaio et al., 2013; Xie et al., 2012 ). The improvement of the colonic inflammatory process observed after treatment of colitic rats with both plant extracts was associated with a decreased expression of the pro-inflammatory cytokines evaluated , thus showing an amelioration of the immune response in colonic inflammation. ...
... When vitamin B12 levels are insufficient, demyelination and degeneration occur in the nervous system, leading to conditions such as optic atrophy, anosmia, glossitis, paresthesia, and cognitive defects [99]. Vitamin B12 regulates growth factors, macrophage function, and the coagulation system, thus, highlighting the potential of vitamin B12 in alleviating severe inflammatory conditions [100]. Vitamin B12 is also an antioxidant [101]. ...