Carmen S Maldonado-Vlaar's research while affiliated with University of Puerto Rico at Rio Piedras and other places

... Furthermore, OT has been proven to reduce the intake of cocaine [41,42], METH [43][44][45] and ethanol [46][47][48][49][50][51][52][53][54]. Additionally, OT prevented the drug-, stressand cue-induced reinstatement of cocaine [41,[55][56][57][58][59][60], METH [39,44,45,[61][62][63][64][65][66][67][68][69][70][71][72] and ethanol [73,74]. Finally, OT has been shown to prevent seeking during extinction and to facilitate the extinction of cocaine- [58,59] and METH-addictive effects [39]. ...

... In direct opposition to the current studies, it has been reported that mGlu 5 receptor NAMs often inhibit the extinction of contextual and spatial memories, whereas positive modulation enhances extinction [60][61][62][63][64]. Notably, these studies consist primarily of aversive learning conditions, such as avoidance learning, startle response, and fear conditioning. Similar to the currently discussed findings on ethanol context and cues, negative mGlu 5 receptor modulation has been shown to block context-paired locomotor conditioning to cocaine and methamphetamine CPP [65,66]. Acknowledging the divergent effects of negative mGlu 5 receptor modulation on cues and contexts associated with positive versus negative stimuli is important. ...

... Furthermore, an increase in striatal expression of D1Rs (but not D2Rs) and an increase in the striatal AVP expression level was observed in morphine-treated animals when housed with identically treated conspecifics but not when housed with drug-naive animals [14], which highlights the significance of social factors in the development of drug addiction. Interestingly, AVP gene expression analysis showed its down-regulation during earlyand mid-acquisition and up-regulation during the late-acquisition and expression of environment-elicited cocaine conditioning [128], which suggests addiction stagedependent changes. Nevertheless, further studies are needed to fully elucidate the interaction between the AVP and DA mesocorticolimbic system in the context of drug reward. ...

... When tested against cocaine-induced locomotor sensitization, the NT antagonist SR48692 given intraperitoneally decreases locomotor activity, but only if given over a two-week period [184]. In contrast, injections of SR 48692 into the NA shell enhance cocaine self-administration in a reinstatement paradigm [185]. NT (8-13) microinjected into the ventral pallidum (VP) reverses cocaine-induced decrease in GABA release, and attenuates cue-induced reinstatement, but paradoxically potentiates cocaine-primed reinstatement [186]. ...

... Dans la recherche de drogue induite par les indices environnementaux, la présentation de stimuli prédictifs de la cocaïne augmente la libération de DA dans le NAc et déclenche un comportement de recherche de drogue (Weiss et al., 2000). De plus, il a été observé qu'une inactivation pharmacologique du NAc a diminué la recherche de drogue induite par les indices contextuels (Fuchs et al., 2004a). ...

... A Nurr1-and Foxa2-mediated anti-inflammatory gene expression profile was manifested in glia cultured from the cortex and hippocampus, where are affected primarily in AD ( [23,24], Fig. 1 and Supplementary Fig. 1), indicating a potential application of those factor expressions to correct pathologic glia in an AD disease context. Furthermore, Nurr1 expression is detectable in the neuronal cells of the hippocampus and cortex [27][28][29][30], and its deficiency in the hippocampus has been shown to cause ADrelated pathogenesis and cognitive function in an AD animal model [27,31]. A meta-analysis of transcriptome data from hippocampus biopsies and cells derived from AD patients pointed to an important role of Foxa2 gene-regulatory networks in the etiology of AD [32]. ...

... Van der Zee et al. have shown that in a hole board test the trained group revealed strong PKC gamma-immunoreactivity in somata and dendrites [1]. Abeliovich et al. demonstrated that PKC gamma deficient mice exhibited mild spatial and cognitive impairment [2] and microinfusion of PKC gamma antisense oligodeoxynucleotide into the nucleus accumbens lead to impaired spatial learning in its early phase of acquisition [3]. Colombo et al. have added information to the subject that protein kinase C isoforms in young and aged rats are linked to spatial memory depending on the subcellular fractions [4]. ...

... Several studies have reported that lithium reduced learning, memory capacity, and other cognitive speed processing in patient, which received lithium in compare with control subjects (Pachet and Wisniewski 2003). Indeed, lithium effects are due to neuroplasticity, which could change the intracellular signaling pathways, transcription factors, and regulation of gene expression (Al Banchaabouchi et al. 2004). Although some reports have shown that lithium can be applied as a potential neuroprotective agent (Lazzara and Kim 2015), other studies have demonstrated the memory impairing effect of lithium and other metals in both human and animal (Amani et al. 2019b;Honarmand et al. 2014). ...

... Same high levels were also observed in untrained rats allowed for a first time to the food search apparatus. Therefore, the activation of CREB may be mainly triggered by spatial novelty (Alvarez et al., 2005). ...

... These include the conventional isoforms dependent on calcium (a, b, and c), novel (d, e, g, and h), and atypical (k and f) types, which are structurally homologous, but can be regulated independently of calcium (Parekh et al. 2000;Weeber et al. 2000;Ohno and Nishizuka 2002). Protein kinase C cascade regulates neuronal efficacy at different levels, including neurotransmitter release, neurotransmitter receptor function and gene expression (Malenka et al. 1986;Ben-Ari et al. 1992;Meberg et al. 1993;Macek et al. 1998;Manseau et al. 1998;Kleschevnikov and Routtenberg 2001), and it seems to play a role in memory formation process Nogues 1997;Alvarez-Jaimes et al. 2005;Alkon et al. 2007;Bonini et al. 2007;Lorenzetti et al. 2008;Nelson et al. 2008;Serrano et al. 2008). There are lines of evidence supporting a role for PKC in learning and memory. ...