Carmen Rubio Lluesa's research while affiliated with IGENOMIX and other places

Publications (8)

Article
Introduction Detection of mosaic embryos and degree of mosaicism is a hot topic in preimplantation genetic testing of aneuploidy (PGT-A). Several groups have reported healthy life births from mosaic embryos. A key point is the degree of mosaicism that can be detected in a trophectoderm biopsy and the impact of next generation sequencing (NGS) proto...
Article
The success of assisted reproduction treatments is based on the selection of the best embryos for transfer, those with the highest implantation potential and ongoing pregnancy rates: euploids. The most reliable method to assess the chromosomal status of preimplantation embryos is preimplantation genetic testing for aneuploidies (PGT-A). Other optio...
Conference Paper
Introduction The introduction of highly sensitive Next Generation Sequencing (NGS) platforms for PGT-A applications concurred with an increased detection of segmental aneuploidies. Recent studies focused on understanding whether segmental aneuploidies derive from mitotic or meiotic events, however, definitive data are still lacking. To further cont...
Chapter
Comparative genomic hybridization arrays (aCGH) allow the analysis of all 24 chromosome aneuploidies and chromosome rearrangements in the same single (or few) biopsied cells in a short period (less than 24 h). When applied to preimplantation genetic diagnosis (PGD) and screening (PGS) this technique can improve the selection of embryos for transfer...

Citations

... Nevertheless, euploid embryos should be chosen first for transfer, and the transfer of mosaic embryos should be coupled with pre-and post-genetic counselling, including the option of a new IVF cycle if there are no euploid embryos in the current cycle, to yield a better prognosis [34]. Segmental aneuploidies which are not uniformly present in blastocysts and have low predictive value in IVF/PGT-A [35,36] were not considered when determining mosaicism in embryos. ...