Carmen Mocanu's research while affiliated with Universitatea de Medicina si Farmacie Craiova and other places
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Publications (48)
The purpose of this study is to identify and quantify preclinical changes with the help of optical coherence tomography angiography (OCTA) within the retinal microcirculation of young type 1 diabetes (T1D) patients without clinical signs of diabetic retinopathy (DR) and to compare these results with those obtained from healthy age-matched subjects....
Leber hereditary optic neuropathy (LHON) is a mitochondrial disease leading to optic atrophy due to degeneration of the retinal ganglion cell. A curative treatment is not available at the moment, but a new antioxidant drug, Idebenone, is expected to reduce the progression of the disorder. Two male patients, genetically confirmed with LHON, were cli...
The Corona virus infection started at the end of 2019 in Wuhan - China and spread rapidly throughout the world, generating the Covid 19 pandemic. The manifestations of the Covid disease were extremely varied, from a simple flu, with fever, cough, weakness, headache, joint pain, up to severe pneumonia, with severe acute respiratory syndrome (SARS-Co...
Purpose. To report a case of malignant glaucoma in a pseudophakic female patient, with no history of glaucoma, resolved through pars plana anterior vitrectomy.
Case presentation. An 80-year-old female patient presented in our Emergency Department after a five-day history of pain in her left eye (LE). In the last day, the patient noticed marked visu...
Pterygium is a common eye disease, which affects both males and females, and is usually described by most patients as painless and unaesthetic. In case pterygium is symptomatic, the perceived ocular discomfort level is determined by a series of symptoms, among which we have studied tearing, foreign body sensation and blurred vision. Based on patien...
Ocular surface squamous neoplasia (OSSN) is a malignant or dysplastic lesion that has its origins in the epithelial cells at the ocular surface. The structures from which these lesions can arise are the conjunctiva, the limbus, and the cornea. Our study was conducted on a group of seven patients with ocular surface squamous cell carcinoma (SCC). Hi...
Introduction. Eales disease is an idiopathic peripheral vascular occlusive disease characterized by inflammation, ischemia, and retinal neovascularization and is hallmarked by recurrent vitreous hemorrhages and vision loss.
Case report. We present a case of a 48-year-old female with recurrent floaters and decreased vision in her right eye. The onse...
Keratoconjunctivitis sicca represents a progressive deterioration of ocular surface produced by a deficient secretion of lachrymal film (quantitative disorder) or excessive tear evaporation (qualitative disorder). The cytological analysis of conjunctival impression in 42 patients with dry eye syndrome established a strong correlation between the cl...
A tumor represents an abnormal tissue growth that can arise from any ocular structure, such as eyelids, muscles or the optic nerve. At the eyelids, there are two main tumor types: basal cell carcinoma and squamous cell carcinoma. Angiogenesis plays a crucial role in growth, invasion and metastasis processes of any tumor. It is well known the fact t...
Ligneous conjunctivitis represents a very rare form of chronic membranous conjunctivitis, with unknown etiology; less than 200 cases have been reported in the literature, most of them in infants and children. After 40 years, this condition appears in exceptional circumstances. We present, in this study, two patients (of 55 and 64 years old) with ve...
Aim:
Posterior vitreous detachment (PVD) is a physiological phenomenon due to aging characterized by separation of the vitreous cortex from the retina and may induce a variety of pathological events at the vitreoretinal junction. The aim of this study is to highlight in vivo anatomical and functional changes in early stages of PVD allowing the cor...
Comparing with other malignant tumors, uveal melanomas determine tardive general spreading. Even in the absence of local treatment, general metastasis is less than 20%, in the first five years, many factors being involved. This paper present a particular case of choroid melanoma with very unusual and unpredictable evolution of the disease; the high...
The diagnosis of RAP is similar with the diagnosis of the AMD, but PED, exudate and superficial hemorrhages are more common in RAP. A 75-year-old male presented himself at the Ophthalmology Department of the Emergency County Hospital in Craiova in January 2015, with a 4 months history of vision loss. In his right eye the visual acuity was 4/50 eye...
Conjunctival melanoma is a rare tumor, while malignant melanoma of the uveal tract is the most common primary intraocular tumor in adults. The authors highlighted the case of a 68-year-old male patient presented in June 2011 in the Ophthalmology Clinic of the Emergency County Hospital of Craiova, Romania, accusing foreign body sensation and the app...
This article presents the results of a study on 85 patients with non-alcoholic fatty liver disease (NAFLD). We evaluate the retinal vascular changes using retinal photography and carotid vascular changes, by ultrasounds, occured in this group of patients.
We present the case of man with endogenous endophtalmitis AO, with Insulin-dependent Diabetes Mellitus type 2 and Viral hepatitis type C. The prognosis was reserved in the context of the underlying disease, with loss of his visual acuity OD and evisceration OS. Despite the correct treatment and many clinical, laboratory, imaging and interclinical e...
Chronic ischemia related to a manifest ophthalmic artery stenosis, determines extremely rare ischemic chronic modifications at the level of the optic nerve, with progressive optic atrophy and visual fun ction alteration. It is presented the case of a 59 years patient, who was hospitalized in Clinic of Ophthalmology, Emergency Clinic Districtual Hos...
Purpose. We present a very rare case of a patient with dramatic temporary and bilateral loss of vision secondary to severe preeclampsia. Case report. In this study, we present the clinical evolution of a pregnant woman in her 27 th week of her second gestation developing severe preeclampsia complicated with temporary blindness. Her visual acuity wa...
Pterygium represents an epithelial hyperplasia associated with fibro-vascular growth. It is an active process, associate with cellular proliferation, remodeling of the connective tissue, angiogenesis and inflammation. The aim of this study consists of emphasizing angiogenesis involvement in the pterygium pathogeny. The material used for this study...
The paper presents the evolution of a diabetic patient with CSME resistant to laser treatment. The intravitreal injection of Triamcinolone Acetonid represented a very efficient therapeutic solution the visual accuity improving for a period of 7-9 months.
Laser therapy in open angle glaucomas represents an important step in their management, a topic of intense research during the second part of the XXth century. The initial enthousiasm generated by spectacular results obtained with minimal risks and complications, was soon tampered by their short survival. Nowadays, laser therapy is considered a sec...
Prospective study on 22 glaucoma patients (31 eyes)--pseudoexfoliation glaucoma and POAG--who underwent nonselective laser trabeculoplasty during 2007. The follow-up time is intended to be 5 years, with a preliminary report at 2 years. Our study wants to evaluate the efficiency and safety of the laser procedure.
The initial success rate was 100%; t...
Dirofilaria repens infection, a zoonotic illness, is rarely seen in humans; it is more frequently met over the endemic areas of the Southern Europe and Sri Lanka. The authors report a case of dirofilaria conjunctivae in a 27 year old woman from Craiova; such infections are hardly to be found in our country. Our patient presented a mobile, bulbar, s...
Introduction Diabetic eye complications, and particularly diabetic retinopathy, produce very severe disorders causing in many cases non-reversible, bilateral blindness, because of its effects on the vascular system, with retinal neovascularization. Aim and Methods 225 patients with diabetic retinopathy have been diagnosed in our clinic of ophthalmo...
The study proposes the evaluation of the Systane effect on people that have severe dry eye sensation, with cornea or conjunctive complications. In order to do this, a study protocol has been adopted which meant comparing the values of lacrimal film break-up time, before and after Systane treatment, comparing cornea and conjunctive staining, compari...
Dans les dernières décades l’ordinateur a été de plus en plus employé dans tous les domaines médicaux. La surveillance des patients, employant une base de données avec utilisation de l’Internet représente actuellement l’orientation principale, vu les nombreux avantages apportés par l’informatique.Matériels et MéthodesEn collaboration avec le départ...
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The authors have suggested to reveal conjunctiva stamp changes in diabetic patients. A set of patients aged between 50 - 80 and having been diagnosed with diabetes mellitus were available for our study, therefore they have been ophthalmologically examined; both Schrimer and BUT tests have been performed. We removed conjunctiva stamps w...
The purpose of this paper is to diagnose the patients with ocular sicca syndrome in major collagenosis, to evaluate the clinical and histopathological lesions, related to stage of the disease and to establish significant correlations between the different clinical tests for qualitative and quantitative determination of lacrimal tear and the severit...
The angiofluorographic aspect of the optic disk is complex and the separation between normal and pathologic is difficult The aim of this study is to distinguish the new etiological, clinical, therapeutic, and evolutive particularities in acute ischemic diseases of the anterior segment of the optic nerve. We performed angiofluorography in 10 patient...
The paper present a clinic and histological study, including all cases of uveal malignant tumours, hospitalized in Ophthalmological Clinic of Craiova in the last 15 years. The follow-up period of cases were 4 years. The diagnosis was established by clinic and paraclinic examination (imaging methods-- MRI, CT, Echo) and histologic examination. The h...
The tear crystallization test permits an easy and quick identification of the lacrimal film alterations existent in the Sicca syndrome. From the 29 crystallization tests done on patients suffering from Sicca syndrome medium and severe form the most frequent was type III crystallization (21 cases-73%), type IV (4 cases-14%) and type I (1 case-3%). T...
The paper presents the vascular morphopathological lesions in diabetic retinopathy. We have initiated a comparative study between normal eye and ocular globes preserved from patients with diabetic retinopathy in different stages of evolution that were fixed and stained by classic histological techniques. We have focus on the histopathological exami...
The paper presents a study of corneal ulcers at aged persons for the identification of etiologic and aggravates factors that may have a negative influence for the prognostic of the diseases.
We have performed a retrospective study using a lot of aged patients with corneal ulcers, hospitalized in 2002-2003 period. The data were obtained by both clin...
The paper realized the retrospective evaluation of all cases of neovascular glaucoma hospitalized in Clinic of Ophthalmology of Craiova in the last 15 years. Neovascular secondary glaucoma represents 3,9% of all glaucomas. The most important etiologic factors were the central venous occlusion, diabetic retinopathy, carotid occlusion, intraocular tu...
The study tried to compare the sclerocorneal limbus in human eyes and animal eyes, using the same histological technique (preserving in paraphine and stained with hematoxylin-eosine, trichromic Goldner-Szekelly and orceine method). The sclerocorneal limbus represents the passage zone between cornea and sclera, and its importance for medical practic...
Over the past several years, there has been important progress in the field of intrinsec mechanisms of ocular neovascularization. Immunohistological studies succeeded a better systematization of the factors that stimulates and inhibits this process. Their presence in different ocular normal structures, without any angiogenic activity, suggests a ph...
The paper presents the infectious complications at patients with diabetes mellitus, and the evolution of these complications with the type of diabetes and the treatment with orale hypoglycemic agents or insulin.
The survey was fulfilled in the Clinic of Ophthalmology of Craiova and in the Metabolic Diseases clinic, during a period of 10 years.
We s...
It is presented the correlation between the uveitis and the focal dental disease with infection, irritation or allergic pathogenicity.
This study was performed on a set of 54 patients with uveitis and dental diseases patients hospitalized in the Clinic of Ophthalmology of Craiova, during 1998-1999. This correlation was observed in 38-40% of uveitis...
The paper reports a study of 216 patients of special deaf-mute schools from Craiova. The exam of them showed us the presence of retinal degenerative lesions in 17 cases (7.8%). There was not a parallelism between deafness' degree and retinal lesions expanse. In point of clinical aspect, the retinal degenerative lesions were Sjögreen retinal lesions...
The paper surveys the statistical results of retrospective analysis for observation sheets of patients having mellitus diabetes, type I and II, hospitalized during the last 10 years at the Ophthalmological Clinic in Craiova. The accent was made on the ocular complications related to the type of mellitus diabetes, the age of its debut, the evolution...
Citations
... These retinal alterations can be attributed to both myopia and T1D and can accelerate the development of sight threatening complications. The normal FAZ in healthy subjects has a circular or slightly elliptical shape which becomes increasingly irregular in patients with DR, altering the FAZ perimeter and FAZ area as well [22]. ...
... The need for new, fast biomarkers that could offer new diagnostic information has recently been highlighted by the SARS-CoV-2 pandemic. Numerous cases of MS with acute ON onset have been reported to be triggered at the same time as SARS-CoV-2 infection, or in some cases after the vaccine [83][84][85][86]. The pathogenic process may have started before contact with the SARS-CoV-2 virus, or the vaccine, but these elements acted as a precipitating factor that triggered the inflammatory response. ...
... We read with interest the letter [1] from Josef Finsterer & Sounira Mehri about our article regarding the morphological and functional response to Idebenone therapy in patients with Leber hereditary optic neuropathy (LHON), where two pediatric patients, genetically confirmed, were periodically followed-up over a period of one year after we initiated the treatment [2]. We thank them for the interest shown in this topic and we want to answer the questions they have formulated regarding our study. ...
... However, no large-scale epidemiologic studies have been performed in populations in the Far East. In addition, recent studies have reported associations between findings such as loss of retinoblastoma protein/P16/cyclin D1, strong p53 immunostaining, and ADAM3A overexpression and the molecular pathology of SCC [5][6][7]. In recent years, research on factors related to tumor immunity, including programmed cell death 1 (PD-1), programmed cell death ligand 1 (PD-L1), and cytotoxic T lymphocyte-associated protein 4 (CTLA-4) has advanced worldwide to encompass aspects ranging from basic research to clinical indications in head-neck SCC [8][9][10][11]. ...
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... YAG laser dapat membuka saluran langsung antara rongga vitreous dan anterior chamber (AC). Tata laksana yang lain diantaranya melibatkan vitrektomi anterior, hialoidektomi anterior, dan kapsulotomi posterior (10). ...
... Among the well-differentiated (G1), moderately differentiated (G2), and poorly (G3) differentiated SCCs, most diagnosed G3 cases showed the deepest tissue infiltration and the highest VEGF positivity. Bălăşoiu et al. [14] also found that the immunoexpression of VEGF and EGFR was more pronounced in moderately or poorly differentiated forms than in well-differentiated SCC forms. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/811609521942530-1570514197599_Q64/Raluca-Ciurea.jpg)
... Although the technology used in the treatment of type 1 DM is constantly advancing, aiming towards better glycemic control [27], other sight-threatening pathologies of patients must be taken into consideration when monitoring the possible retinal complications. Highresolution OCT techniques which allow for the evaluation of retinal layers [28] along with angio-OCT microvascular retinal evaluation are necessary screening tools for preventing sight-threatening complications in young diabetic patients with high myopia. ...
... Eales' disease is an idiopathic peripheral retinal vasculopathy characterized by vasculitis, ischemia, retinal neovascularization, and recurrent vitreous hemorrhages [1]. Eales' disease is a diagnosis of exclusion. ...
... The first report of ligneous conjunctivitis in a 46-year-old man with bilateral pseudomembraneous conjunctivitis was published by Bouisson as early as 1847 [3]. Overall, less than 200 cases have been reported in the literature up until 2021 [1,4]. Maamri et al. ...
... Tear osmolarity, which is an indicator of dry-eye disease, is higher in patients with primary Sjögren's syndrome than in healthy individuals (6) . Conjunctival impression cytology examinations revealed squamous metaplasia, including goblet cell loss, in patients with Sjögren's syndrome (7) . However, the effects of primary Sjögren's syndrome on the thickness of the anterior sclera, corneal layers, and tear film were not investigated yet. ...
