Carmen Freire-Cobo's research while affiliated with Icahn School of Medicine at Mount Sinai and other places

Publications (4)

Article
While humans exhibit a significant degree of neuropathological changes associated with deficits in cognitive and memory functions during aging, non-human primates (NHP) present with more variable expressions of pathological alterations among individuals and species. As such, NHP with long life expectancy in captivity offer an opportunity to study b...
Article
Age-related cognitive decline has been extensively studied in humans, but the majority of research designs are cross-sectional and compare across younger and older adults. Longitudinal studies are necessary to capture variability in cognitive aging trajectories but are difficult to carry out in humans and long-lived nonhuman primates. Marmosets are...
Preprint
Full-text available
Impaired synaptic function is a common phenotype in animal models for autism spectrum disorder (ASD), and ASD risk genes are enriched for synaptic function. Here we leverage the availability of multiple ASD mouse models exhibiting synaptic deficits and behavioral correlates of ASD and use quantitative mass spectrometry with isobaric tandem mass tag...
Article
Neurexins (NRXNs) are cell-adhesion molecules important in the formation and remodeling of neural circuits. It has been shown that aversive environmental stimuli can affect the expression pattern of Neurexin genes (Nrxns) impacting the regulation of synaptic strength. Accumulated evidence suggests that, after chronic exposure to psychological stres...

Citations

... 20,[22][23][24] Accumulating data suggest that NHPs undergo reductions in brain volume reminiscent of human aging, 19,[25][26][27][28] and several NHP models of AD indicate that elderly animals develop early ADlike neuropathologies, including the accumulation of amyloid beta (Aβ) plaques and hyperphosphorylated tau. 29 Diminished cognitive abilities with aging have been demonstrated in several species, including marmosets, 30,31 rhesus macaques, 32,33 and chimpanzees. 34 to older aged female vervet monkeys (ages 8-29 years). ...
... The common marmoset (Callithrix jacchus) has gained interest as a model for human aging (Ross, 2019), due in part to its short lifespan of 10−12 years, which allows for longitudinal investigations (Rothwell et al., 2021). Additional characteristics, such as small size (300−500 g) and ease of breeding, make them highly suitable as laboratory animals. ...
... The GCI − also provides a promising genetic resource for investigating the cerebellar involvements in emotion-cognitional behaviors and related brain diseases. For example, the observed overlapping genes, i.e., NRXN1, are associated with mental depression and autistic disorder supported previous clinical studies showing that rare and common variants in NRXN1 carried risks for MDD [98], ASD, and schizophrenia [99]. And HTR1A, which has a high expression in the cerebellum [14] and has been linked to the cognitive process in both animal models and human [79], was found to be involved in pain, mental depression, autistic disorder, alcoholic intoxication, learning disorder, and other conditions (Supplementary Sheet 27). ...