Carl W Dieffenbach’s research while affiliated with National Institute of Allergy and Infectious Diseases, National Institutes of Health and other places

... 26 Investment in research and development has accelerated vaccine creation and improved HIV treatments. 27 Integration of health services has enhanced resilience, while a focus on preparedness ensures readiness for future health emergencies. These lessons aim to improve global health outcomes and create robust systems capable of addressing complex public health challenges. ...

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Comparative Analysis of Virology and Pathogenesis of SARS-CoV-2 and HIV Infections: Implications for Public Health and Treatment Strategies

... Their perspectives, experiences, and needs can provide valuable insights and contribute to more effective research and product development strategies. In doing so, it will be important to ensure that an HIV vaccine is developed and integrated into existing and future effective prevention strategies [37]. ...

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In danger: HIV vaccine research and development in Europe

... The study's prediction for the AIDS incidence in Shandong Province from 2023 to 2030 reveals an increasing trend, with an expected incidence of 6.33 in 2030. Despite the United Nations Sustainable Development Goals aiming to end the AIDS epidemic by 2030 25 . the prediction suggests that AIDS in Shandong Province continues to exhibit an increasing trend, highlighting a significant gap from the 2030 target. ...

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Spatial change, time tendency and projection to HIV/AIDS incidence in an eastern province of China

... Additionally, research indicates that a scenario such as PIC is more likely than complete HIV elimination 7,8,10,[31][32][33][34][35][36][37] . This implies that PHIV and key populations will not have a choice between PIC or HIV elimination as a new treatment option. ...

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The expected impact of a cure for HIV among people with HIV and key populations

... countries (UK and South Africa), highlighting the need for additional high-quality experimental studies in PLWH. This is particularly important for SARS-CoV-2 vaccines based on adenovirus type-5 (Ad5) platforms, given prior concerns associated with higher risk of HIV acquisition in participants of Ad5 vectored HIV-1 vaccine trials [10]. Although follow-up data from one of these studies did not find increased risk of HIV progression among participants who became HIV-infected, it remains critical to monitor the effects of other Ad-5-based vaccines on HIV infection and progression [11]. ...

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Immune response induced by the recombinant novel coronavirus vaccine (Adenovirus type 5 vector) (Ad5-nCoV) in persons living with HIV (PLWH)

... Similar poor awareness results have been reported in other countries. [19][20][21] In response, various governments have taken steps, such as observance of HIV vaccine awareness day on May 18. [22] However, there is a need to create further awareness through various social media platforms, tele advertisements, and national policies. ...

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Awareness and Hesitancy of COVID 19 and other.19

... Recent estimates indicate that 4 million lives could have been saved if an effective antiviral had been available within 6 months of the start of the pandemic 5 . Moreover, although effective SARS-CoV-2 vaccines were quickly developed, this is not always possible for all viruses, as is the case of HIV-1 6 . Even for SARS-CoV-2, it has taken years for COVID -19 vaccines to reach 20 % of the population in low-income nations 7 . ...

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Targeting eEF1A reprograms translation and uncovers broad-spectrum antivirals against cap or mA protein synthesis routes

... [12][13][14][15] As such, both federal and local ending the HIV epidemic (EHE) efforts are increasingly turning to implementation science to accelerate and support intervention uptake and dissemination in the field. [16][17][18][19][20][21] Implementation strategies are the building blocks of effective implementation; they refer to specific methods and techniques designed to enhance adoption, administration, and sustainment of interventions in practice. 22,23 The implementation science field has developed a collection of 73 specific implementation strategies, called the Expert Recommendations for Implementing Change (ERIC) compendium, 24 which have been grouped into 9 thematic clusters. ...

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Developing a Practice-Driven Taxonomy of Implementation Strategies for HIV Prevention

... In recent years, the concept of "Undetectable = Untransmittable" (U = U) has emerged as a transformative framework for understanding outcomes. The U = U principle asserts that PLWHA who receive ART and maintain an undetectable viral load-defined as fewer than 200 copies/mL-for at least 6 months cannot sexually transmit the virus to others (Cohen et al., 2016;Eisinger et al., 2019). This concept, supported by robust scientific evidence, has significantly shaped global HIV treatment and prevention strategies (Bavinton et al., 2018;Rodger et al., 2019;Phanuphak et al., 2020). ...

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Perceived Stigma, Internalized Stigma, and Mental Health of Young Chinese Men Who Have Sex With Men Living With HIV/AIDS: Intersection and the Importance of “Undetectable = Untransmittable” Status

... [17][18][19][20][21][22][23][24] The US government including the NIH, the Centers for Disease Control, and Health Resources and Services Administration have thus invested significantly in recent years in efforts to End the HIV Epidemic in the United States through implementation science and scaling of evidence-based practice. 9,[25][26][27] Funding for IR both in the United States and internationally has been steadily increasing in recent years. 1 There is often a lengthy delay in evidence generation, although some of this may be field specific. 11,12,[28][29][30] The objective of these analyses was to review the scientific production process and time to dissemination of HIVrelated IR findings. ...

Reference:

Data Velocity in HIV-Related Implementation Research: Estimating Time From Funding to Publication