Carl H. Lücking’s research while affiliated with Protestant University of Applied Sciences Freiburg and other places

... Gait disorders secondary to conditions such as arthritis, orthostatic hypotension, Parkinson disease, vitamin B 12 deficiency, hypothyroidism, heart rate or rhythm abnormalities, or depression may respond to medical therapies. 16,23,29 Although data are limited, surgery may improve gait for patients with cervical spondylotic myelopathy, 51 lumbar spinal stenosis, 52 normal-pressure hydrocephalus, 53 or arthritis of the knee or hip. 54,55 Insertion of pacemakers in patients with carotid sinus hypersensitivity and first eye cataract surgery have been shown to reduce the rate of falls. ...

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Gait and Balance Disorders in Older Adults

... Like other measures, the PERG response is highly dependent on the spatial, temporal and contrast characteristics of the stimuli used, such as gratings or checkerboards. However, studies have consistently shown alterations in both latencies and amplitudes of PERGs in PD (Nightingale et al., 1986;Gottlob et al., 1987;Peppe et al., 1992Peppe et al., , 1998Langheinrich et al., 2000;Sartucci et al., 2006). In contrast to a global reduction in amplitude of PERG response, to a variety of sinusoidal grating spatial frequencies, in age-matched controls compared to young controls, PD patients have shown a specific medium-frequency deficit (Tagliati et al., 1996), the region of peak sensitivity of CS for a normal observer. ...

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Visual processing mechanisms within magno, konio and parvocellular systems : implications for basic and clinical sciences

... An example to demonstrate this is the correlation coefficient, quantifying the bivariate interaction, and its multivariate counterpart the partial correlation. We will use this as an example throughout the manuscript, but our approach is readily applicable to other linear interaction measures such as coherence and partial coherence 13,15 as well as nonlinear interaction measures such as the phase synchronisation and partial phase synchronisation approach 16 . We propose a new method to reconstruct the multivariate network that reduces the dimensionality of the correlation matrix by automatically merging highly correlated nodes before inverting the matrix. ...

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Inferring the underlying multivariate structure from bivariate networks with highly correlated nodes

... 50 Rarer and poorly understood are palatal, dystonic, orthostatic, task-and position-specific, Holmes', cerebellar, and neuropathic tremors. 60 Among PMDs, tremor is the most common phenomenon. 61 Tremors and their physiologic generators are characterized as mechanical, peripherally induced, or central according to the source of their oscillatory activity. ...

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Middle Ear Myoclonus: Two Informative Cases and a Systematic Discussion of Myogenic Tinnitus

... Zur Abgrenzung zum Spasmus hemifacialis hilft auch das Babinski-Zeichen-2, da beim Spasmus hemifacialis bei der Kontraktion des M. orbicularis oculi die Augenbraue gleichzeitig und unwillkürlich durch Aktivierung des M. frontalis angehoben wird. Hier kann auch der Blinkreflex mit Nachweis einer lateral spread response[11] hilfreich sein. Der Blinkreflex kann auch zur Differentialdiagnostik bei möglichen Synkinesien nach peripherer Facialisparese genutzt werden. ...

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Therapie des essentiellen Blepharospasmus mit Botulinumtoxin

... Genome-wide association studies (GWAS) identified >20 LOAD risk genes linked to endocytosis, inborn immunity, and lipid metabolism [143,145]. EOAD is typically diagnosed between 40 and 50 years of age, comprises 5% of the total AD cases [146], is linked to a defect in chromosome 14 and myoclonus [147,148], and, therefore, it is referred to as a distinctive autosomal dominant inherited form of AD [140]. Usually, people with Down's syndrome are more prone to EOAD [149]. ...

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A Review of the Recent Advances in Alzheimer’s Disease Research and the Utilization of Network Biology Approaches for Prioritizing Diagnostics and Therapeutics

... Surprisingly, although reading mirrored script has attracted a substantial amount of attention in cognitive science (Chandra et al., 2020;Kowler & Anton, 1987;Rabe et al., 2021) and neuroscience (Kassubek et al., 2001;Poldrack et al., 1998;Poldrack & Gabrieli, 2001;Ryan & Schnyer, 2007), studies investigating readers' eye movements while reading mirrored script are relatively scarce and have mainly focused on saccade targeting. For example, Kowler and Anton (1987) investigated the eye movements of two participants who read texts in which individual letters, words, or whole texts were either vertically or horizontally mirrored. ...

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EXPRESS: Reading vertically and horizontally mirrored text: An eye movement investigation

... Учитывая неоднородность клинических проявлений, длительность заболевания, а также предполагаемое различие механизмов развития тремора при БП, можно предположить, что препараты, применяемые при БП, имеют разное влияние на симптомы заболевания, в том числе и на дрожательный гиперкинез [5][6][7][8]. Также необходимо отметить, что большинство клинических исследований, посвященных эффективности коррекции дрожательного гиперкинеза, основаны на субъективных оценках пациента и/или специалиста и не включают сравнение результативности более чем двух противопаркинсонических средств. ...

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Efficacy of antiparkinsonian therapy in tremor correction according to tremorography

... Clinical features include spontaneous remissions, paroxysmal exacerbations, the coexistence of rest, postural and action tremors, and fluctuating frequency and amplitude. [63][64][65][66][67][68][69][70] Symptoms are often modulated by cognitive or emotional factors, serving as diagnostic clues. ...

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Functional Movement Disorder: Evolving Mechanisms, Diagnostic Precision, and Personalized Multidisciplinary Care

... Previous clinical studies on the effect of disease progression on tremor produce mixed conclusions. One longitudinal study on PD tremor frequency found that frequency decreases by approximately 0.1 Hz per year, on average [52]. However, a significant change in frequency was only observed in about half of the patients, with 30% of those patients exhibiting a frequency increase rather than decrease. ...

Reference:

Parkinsonian Tremor as Unstable Feedback in a Physiologically Consistent Control Framework