Carine Nzirorera's research while affiliated with Dalhousie University and other places

... Accordingly, when samples collected for LPA measurement include active inhibition of both LPA production and degradation it appears the plasma from healthy individuals harbor on the order of 50 nM LPA. 3,36,37 However, systemic levels of extracellular LPA and autotaxin (ATX), the enzyme predominantly responsible for extracellularly produced LPA, are often found significantly elevated in human chronic inflammatory disorders such as chronic viral (HCV, HBV, and EBV) infections 38-41 autoimmune diseases, [42][43][44] obesity, [45][46][47][48][49][50][51][52] and a number of diverse cancers. [53][54][55][56][57][58][59][60] In these settings, serum LPA levels are considerably heightened (~twofold to 10-fold) compared to healthy individuals and concentrations over 50 μM have been reported in malignant effusions of ovarian cancer patients. ...

... LPA, is a phospholipid having a key role in directing several cellular processes such as survival, proliferation, differentiation, motility and its increased levels have been detected in RA. LPA binds to known G-protein coupled receptors (GPCRs) to execute a broad range of biological functions including its role in CVDs 28 . In chronic inflammatory arthritic condition, LPA receptor signalling may promote atherosclerosis development. ...

... Cycling conditions were set at 95 °C for 10 min, followed by 40 cycles at 95 °C for 15 s and 60 °C for 1 min. All real-time PCR data were normalized to the housekeeping gene RPL 41 [18] using a standard curve. ...

... 3. Under controlled conditions, the heart balances fatty acid uptake, metabolism, and oxidation to maintain energy generation, membrane biosynthesis, and lipid signaling [8] . ...