Canjian Wang's research while affiliated with Jiangxi University of Traditional Chinese Medicine and other places
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Publications (10)
Meloxicam (MLX) is one of the most effective NSAIDs, but its poor water solubility and low bioavailability limit its clinical application. In this study, we designed a thermosensitive in situ gel of the hydroxypropyl-β-cyclodextrin inclusion complex (MLX/HP-β-CD-ISG) for rectal delivery to improve bioavailability. The best method for preparing MLX/...
Systemic lupus erythematosus (SLE) is a debilitating autoimmune disorder characterized by unknown pathogenesis and heterogeneous clinical manifestations. The current existing serum biomarkers for SLE have limited sensitivity or specificity, making early and precise diagnosis difficult. Here, we identified two N-glycans on serum immunoglobulin G (Ig...
Ischemic stroke is a difficult-to-treat brain disease that may be attributed to a limited therapeutic time window and lack of effective clinical drugs. Nasal–brain administration is characterized by low systemic toxicity and is a direct and non-invasive brain targeting route. Preliminary studies have shown that the volatile oil of Chaxiong (VOC) ha...
Elaeagnus L. is found in wild or grown as ornamental plants and is increasingly regarded as underutilized berry shrubs by breeders. This genus has cosmopolitan distribution with various species widely distributed in China, Europe, the United States, and Canada. Interspecific hybrids, which have been reported several times, have attracted intense in...
Ultra-high-performance liquid chromatography coupled with quadrupole/time-of-flight mass spectrometry (UHPLC-Q/TOF-MS) in positive ion mode was used to profile and identify the major constituents in Euphorbia fischeriana Steud. (E. fischeriana). An Agilent ZORBAX SB-C18 column was used to separate the crude extract of E. fischeriana, and the mobile...
Guanjiekang (GJK) that is formed by five medicinal herbs including Astragali Radix, Aconiti Lateralis Radix Praeparaia, Glycyrrhizae Radix et Rhizoma, Corydalis Rhizoma and Paeoniae Radix Alba was used for the treatment of rheumatoid arthritis (RA). However, the pharmacokinetic (PK) profile of active components in GJK remains unclear. This study ai...
An ultra high performance liquid chromatography coupled to triple quadrupole mass spectrometry (UHPLC-QQQ-MS/MS) method has been developed to evaluate the quality of a pharmaceutical herbal preparation, Guanjiekang (GJK), through a simultaneous determination of 13 major active compounds with a huge difference in level of content. Chromatographic se...
Citations
... -no cytotoxicity in rat nasal tissues [193] alzheimer -no cytotoxicity in rat nasal tissues [195] glioma there are different polymers or mucoadhesive agents stated in different investigations for in-situ gelation, but only a few have been listed to be acceptable for the intranasal delivery of brain acting cargos. Despite the strong points of nasal in-situ gel approach, the small surface area of the nasal cavity limits the molecules absorption from the nasal tissue. ...
... 48 A correlation between the level of IgG-G2F and ESR in patients with AS (|r| ¼ 0.42) was identified. 20 Therefore, IgG N-galactosylation may be involve in regulating the disease activity in patients with SpA. Moreover, this could be a novel direction to explore the pathogenesis of SpA and reflected the status of the disease. ...
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... Recent studies have shown that diterpenoids, triterpenes, sesquiterpenes, acetophenones, steroids, and tannins are the primary active components of EFS. [5][6][7] Volatile oils contain a mixture of various chemicals including aldehydes, aliphatic and aromatic compounds, and terpenes. These compounds are an indispensable part of Chinese herbs which play an important role in the therapeutic application of TCM. ...
... The UHPLC-MS/MS method provides high sensitivity and selectivity, and can be used for microanalysis of multi-components [21]. In recent years, it has been rapidly developed into an important method for measuring the composition of trace components in food and drugs [22][23][24][25][26]. The present study was carried out to determine the pharmacokinetics of rutin, avicularin and quercitrin in rats. ...
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... Simultaneous determination showed extreme variation in 13 components of the GJK formula, such as alkaloids and triterpenoid saponins [34]. Another blend of oriental medicine, the Palmultang formula (PLMT), with eight drugs: Ginseng radix, Glycyrrhizae radix, Hoelen, Atractylodis rhizoma, Angelicae gigantis radix, Cnidii rhizoma, Paeoniae radix and Rehmanniae radix; a quali-quantitative analytical method was developed. ...
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