C.K. Atal’s research while affiliated with CSIRO BioFoundry and other places

... Експериментально підтверджено здатність смоли Boswellia serrata інгібувати синтез глікозаміногліканів та запобігати деградації сполучної тканини при різних запальних процесах у суглобах. Також доведено здатність камеді (в експерименті на щурах) знижувати рівень холестерину та тригліцеридів у сироватці крові [18]. ...

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The safety assessment of the dietary supplement “Rheumacаre Ultra”: the optimizing of dietary conditions for the functioning of joints

... Picrorhiza kurroa is one of the most commonly used medicinal plant in Asian countries especially in the Himalayan belt of India. This plant is used against a wide array of diseases and disorders like inflammation (Jayaweera;Nadkarni, 1954), treatment of bronchial asthma (Rajaram, 1976), infectious hepatitis (Mittal et al., 1978), and arthritic pain of bone joints (Langer, 1981). The root and leaf extracts are known to boost humoral and cell mediated immunity (Atal et al., 1986;Sharma et al., 1988). ...

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Medicinal plants with immunomodulatory properties

... Vanillin and 4-methylpentan-2-one reacts under Claisen-Schmidt conditions yielding corresponding enone compound (E)-1-(4-hydroxy-3-methoxyphenyl)-5-methylhex-1-en-3one, 2a in good yield, Scheme 1. Compound 2a was prepared according to slightly modified procedure [39]. A set of its O-alkyl derivatives, compounds 2b-g, was prepared by alkylation of free phenolic group in 2a with corresponding alkyl halides, according to the described literature procedures, [29,30,40], Scheme 2. Compounds 2a and 2b are known compounds and their chemical synthesis was published earlier [41,42]. Compounds 2c-g are new compound and their structure and spectral data are given. ...

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Synthesis of O-alkyl derivatives of dehydrozingerone analogues

... The mixture of these acids is known as D-003 [ Figure 2]. [17] Although fatty acid and fatty alcohol are reported as major constituents [18][19][20][21][22] various phytosterols (19 -22), steroids (23 -28), and higher terpenoids (29 -30) have also been reported in sugarcane wax [23,24] [ Figure 3]. ...

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Phytochemical profile of sugarcane and its potential health aspects

... Kutajarista (200 mL; original pH 4.5) was treated using a published procedure for the enrichment of an alkaloid extract (Bhutani et al., 1984). The preparation was partitioned with chloroform (3 × 200 mL) to remove the neutral components, and the remaining aqueous portion of the formulation was basified by the addition of aqueous ammonium hydroxide (30%). ...

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Chromatographic Analysis of Kutajarista—an Ayurvedic Polyherbal Formulation

... 19 Atal et al. prepared five glycosylated psoralen derivatives including 9-b-D-arabinopyranosyl psoralen 3 and found that it caused dose dependent inhibition of spontaneous motor activity, prolongation of hexabarbitone, pentobarbitone, and ether hypnosis. 20 Considering that introducing sugar moieties into pharmacophores, natural products or prodrugs can improve their anticancer activities, 22e30 we embarked on the design and synthesis of glycosylated psoralen derivatives and the evaluation of their Scheme 1. Structures of some glycosidic psoralen derivatives. antiproliferative activities against several human tumor cell lines and antioxidant activities. ...

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Synthesis and biological evaluation of glycosylated psoralen derivatives

... The procedures for its synthesis have been extensively studied and such studies have been stimulated by various promising applications, especially in the case of highly substituted 4-hydroxycoumarin derivatives. In fact, certain substituted chromene are used as antimicrobial, anticancer, anti-inflammatory, antidepressant, anticonvulsant, antihyperglycemic, antipyretic, antibacterial, antifungal activities, fungicidal, anti-arthritic activities [1][2][3][4].The knowledge of such applications has pointed out that substituted 4-hydroxycoumarin are important target to be prepared to our interest on synthesis and molecular structure determination of some types of 4-hydroxycoumarin [5]. ...

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The Synthesis of Xanthene Derivatives Catalyzed by Mixed Tartrate as an Efficient Catalyst

... Different Boswellic acids have been identified including β-Boswellic acid, α-Boswellic acid and these belong to the family of pentacyclic triterpenes. Boswellic acids have been reported as inhibitors of 5lipoxygenase, the key enzyme for leukotriene biosynthesis in inflammatory disorders and human leukocyte elastase [1][2][3][4][5][6][7][8][9][10][11][12][13][14] . Docking studies of Boswellic acid is carried out on lipoxygenase target to identify the most potent inhibitor of lipoxygenase protein among Boswellic acids and their derivatives. ...

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Docking of Boswellic Acids and their Derivatives on Anti-Inflammatory and Anti-Cancer Target

... It has been reported that allopolyploids from O. basilicum x O. americanum had higher herbage and essential oil content (Dhar, 1999). The cultivar 'Clocimum' resulted from the cross between O. gratissimum and O. basilicum, is reported to be a cheap source of eugenol (Sobti et al., 1982). Recently, Ben-Naim et al. (2018) (Maurya et al., 2022) or exhibited tolerance to cold (Dhawan et al., 2016). ...

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Crop wild relatives of spices, medicinal and aromatic plants: What can they offer?

... It was revealed that no relevant data showed any abortion effect when the dose range was minimum, i.e., 10-80 mg. In contrast, it showed its abortion activity in 12 cases with the increasing dosage forms [215]. Furthermore, by the decoction procedure, the leaves were given to pregnant women to stimulate and heal the pain both in pre and post-delivery time whereas the roots helped to destroy the fetus and during birthing in Bihar [216]. ...

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Adhatoda vasica (Nees.): A Review on its Botany, Traditional uses, Phytochemistry, Pharmacological Activities and Toxicity