C W Chi's research while affiliated with National Yang Ming University and other places

... The obtained plasma samples were stored at -80°C until analysis of the plasma NE and epinephrine (EPI) concentrations. The plasma NE and EPI concentrations were determined by a modification of the high-performance liquid chromatography electrochemical assay with 3, 4-dihydroxybenzylamine as the internal standard (12,13). ...

... It was shown that the K variant was considerably less effective in attenuating the accumulation of Aβ fibrils than BChE wild-type [36,40]. The association between BChE-K variant and AD risk was intensively debated and studied, but no definitive correlation was established since some of the previous results supported the idea [41,42], while other researchers remain doubtful [43,44]. Although many of these studies are based on a metaanalysis, GWAS (genome-wide association study) and cohort study, the results are still inconsistent, and the role of BChE in AD pathology remains unexplained [45,46]. ...

... Cell vitality can be enhanced by estrogens (17-b-estradiol) and reduced by anti-estrogens (tamoxifen) via the activity of the estrogen-receptor (ER). Primary trophoblast cells and the Jeg3 and BeWo carcinoma cell lines have been found to be positive for ERa and ERb [25][26][27]. The positive ER mediation becomes obvious by the significantly contrasting estradiol and tamoxifen effect on the vitality of primary trophoblast cells (Fig. 2c). ...

... Programmed cell death is defined by morphological and biochemical modifications in cells (e.g., DNA fragmentation) (Debatin 2004). Dietary phytochemicals induce apoptosis in various cancer cell lines, namely human breast cancer (Valcic et al. 1996), lung cancer (Yang et al. 1998 (Hakimuddin et al. 2004), lung cancer (Nguyen 2003) and hepatoma (Chi et al. 1997). Moreover, these flavonols have also been shown to promote morphological mutation and DNA cleavage in leukemia (Csokay et al. 2005) and rat pancreatic carcinoma cells (BSp73AS) (Mouria et al. 2002). ...

... Inhibition of astrocyte activation via blocking nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and suppressing c-Jun N-terminal kinase (JNK) and ERK pathways (Lee et al. 2014b). Microarray analysis identified the exact genes intervening ↓brain injury, microglial activation (Li et al. 2012b;Song et al. 2012b;Kuang et al. 2017;Zhang et al. 2017b, c) L-DOPA (Chen et al. 2007;Cheng et al. 2008;Mu et al. 2011;Lee et al. 2014b;Gao et al. 2015) 6-OHDA (Im et al. 2005(Im et al. , 2006Lee et al. 2005;Mu et al. 2009;Zhang et al. 2012b;Wang et al. 2013c (Lin et al. 2011;Xiong et al. 2012;Guo et al. 2014) Wang et al. 2004Wang et al. , 2013aGeng et al. 2010;Yin et al. 2011;Wei et al. 2014;Xiong et al. 2014;Chen et al. 2015a;Ding et al. 2015;Cheng et al. 2016;Xiao et al. 2017) AlCl3 ...

... On the other hand, these findings propose that catechin promotes osteogenesis by enhancing the PP2A level, which untimely hinders the ERK signaling in hMSCs [146]. Dental Pulp Stem Cells (DPSCs) are the major source of osteoprogenitor cells and are also reduce bone regeneration regarding their differentiation potential [147,148]. ...

... This is attributed to the inhomogeneous release of energy from the targeted tissue. Considering the small range of 7 Li and 4 He particles, the effectiveness of BNCT depends on the precise location and accumulation of boron within the tumor cells [32]. Therefore, it is imperative to study the physiology, pharmacokinetics, organ distribution, retention, and excretion of 10 B in the patients [33]. ...

... Mitochondrial dysfunction-increased ROS might upregulate amphiregulin to promote cell migration of hepatoma cells [84]. ROS-heat shock factor 1-claudin-1 was found to be involved in mitochondrial dysfunction enhanced invasiveness of hepatoma cells [85]. ...

... Lastly, retained occult intraocular foreign bodies may induce changes reminiscent of the pigmentary changes seen in RP. They can cause damage via direct entry into the eye and subsequent ricocheting inside the eye, resulting in a pigmentary retinopathy caused by metabolic changes like oxidative stress [79]. Specifically, iron or copper foreign bodies can cause siderosis bulbi or chalcosis [80,81], respectively. ...

... Isoquinoline core finds its presence in many natural alkaloids like papaverine [2], berberine [3], curicyleatjehine [4], ecteinascidin [5], cryptaustoline [6], labrandine [7], roebramine [8], chaetoindicin A [9], neocaryachine [10]. Isoquinolines show multiple bioactivities, like dimethisoquin [11] acts as anaesthetic; quinapril [12], debrisoquine [13] acts as antihypertensive agent; 2,2'hexadecamethylenediisoquinolinium dichloride [14] acts as antifungal and antiseptic agent; N-laurylisoquinolinium bromide [15] acts as disinfectant; papaverine acts as vasodilator. Besides this pyrrolidine cores are also pharmacologically active scaffolds. ...