C. R. Williams’s scientific contributions

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Publications (1)

An atlas of gas chromatographic profiles of neutral steroids in health and disease
  • Article

August 1981

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5 Reads

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13 Citations

Chromatographia

C. R. Williams

Citations (1)

... metabolome of what is now termed P450 oxidoreductase deficiency (ORD) was accurately described long ago by thin layer chromatography and GC/MS urine profile analysis and was named combined 17α- hydroxylase/21-hydroxylase deficiency111213. Patients with ORD present with a pathognomonic urine steroid profile showing increased metabolites typically seen in 21- hydroxylase deficiency, such as pregnanetriol, 17-OH-pregnanolone and pregnanetriolone (17OHP and 21-deoxycortisol metabolites) increased excretion of mineralocorticoid precursors (corticosterone metabolites) and decreased excretion of active androgen metabolites [13]. ...

Reference:

Gas chromatography/mass spectrometry (GC/MS) remains a pre-eminent discovery tool in clinical steroid investigations even in the era of fast liquid chromatography tandem mass spectrometry (LC/MS/MS)
An atlas of gas chromatographic profiles of neutral steroids in health and disease
  • Citing Article

  • August 1981

Chromatographia

C. R. Williams