C. Brunet's research while affiliated with Université de Montpellier and other places

Publications (41)

Article
Full-text available
Introduction Poor responder patients remain a challenge in assisted reproductive technologies. The “short agonist stop” (SAS) stimulation protocol uses a double stimulation (flare up effect with the gonadotropin-releasing hormone (GnRH) agonist (GnRH-a) then gonadotropins) associated with a less strenuous blockage (discontinuation of GnRH-a) to fav...
Article
L’objectif de l’étude était de déterminer si le taux d’arrêt de l’acétate de Cyproterone ANDROCUR®, progestatif anti-androgénique utilisé pour traiter l’hyperandrogénie, était plus important en 2019, suite à l’alerte de l’Agence Nationale de sécurité du médicament (ANSM) d’octobre 2018 sur le risque de méningiome associé à l’ANDROCUR®. Nous avons m...
Article
Full-text available
Abstract Early gestational diabetes mellitus (eGDM) is diagnosed when fasting plasma glucose before 24 weeks of gestation (WG) is ≥ 5.1 mmol/L, whilst standard GDM is diagnosed between 24 and 28 WG by oral glucose tolerance test (OGTT). eGDM seems to have worse obstetric outcomes than standard GDM. We compared the rates of postpartum glucose metabo...
Article
Background Pregnant women with type 1 diabetes (T1D) have high risk of complications despite improved care based on technology advancements.Objective To assess the effects of pregnancy planning on fetal and maternal outcomes in T1D women treated with continuous subcutaneous insulin infusion (CSII).Study designWe retrospectively assessed maternal an...
Article
Full-text available
Access to in vitro fertilization (IVF) for obese women varies across centers, and the impact of obesity on IVF outcomes is widely discussed. We assessed the impact of obesity and its severity on live birth rate (LBR) after IVF. We included women treated for IVF in our center. Data were prospectively collected in the BabySentryTM software. LBR per c...
Article
Full-text available
Details Session title: Endometriosis, endometrium and and falopian tube, and benign disorders of the endometrium and fallopian tube Session type: Poster viewing session Presentation number: P-309  High pregnancy rate with customized embryo transfer after endometrial receptivity assessment using a transcriptomic approach in patients candidate for e...
Article
Although many studies have demonstrated the superiority of ultra-fast freezing compared with slow freezing, the debate is still ongoing concerning the best type of vitrification method: direct exposure to liquid nitrogen (i.e., open systems), or sterile system without contact with liquid nitrogen (i.e., closed systems). The aims of this study were...
Poster
Full-text available
Study question: Beyond the genes, do miRNAs are associated to endometrial receptivity status during the expected implantation windows? Summary answer: We identified five specific miRNAs associated to a receptive endometrium compared with non-receptive endometrium during the implantation windows What is known already: To date, there are few studies...
Article
Full-text available
1/33), and 0% (0/21), respectively. The respective pregnancy rates of BT were 7.5% (3/40), 4.2% (1/24), 0% (0/11), and 0% (0/5). The pregnancy rates of D3ET showed the higher tendency than that of BT. The rate of spontaneous abortion (D3ET) was 40.7% (11/27), 76.9% (10/13), 75.0% (6/8), and 100% (1/1), respectively. All the pregnancies resulting fr...
Article
Full-text available
Circulating or "extracellular" microRNAs (miRNAs) detected in biological fluids, could be used as potential diagnostic and prognostic biomarkers of several disease, such as cancer, gynecological and pregnancy disorders. However, their contributions in female infertility and in vitro fertilization (IVF) remain unknown. This study investigated the ex...
Article
Introduction: Infertility in developing countries are mainly due to tubal injuries, making essential IVF; IVF costs but this, should be reduced to be accessible to people, and not be seen as a luxury in this part of the world but rather an psycho-social emergency. Simplifying attempts monitoring means can decrease these costs, provided that the res...
Article
Whether or not we should allow a fifth attempt at IVF remains a debatable subject as the costs involved for society are high and the pregnancy rates are low. Should we only choose the patients with acceptable chances of pregnancies? What should we offer in case of repeated implantation failure? The following clinical case illustrates this situation...
Article
To evaluate the effect of induced blastocoele shrinkage before vitrification in a closed carrier device. Prior to vitrification, blastocyst cavity was artificially shrinked by laser pulse or not treated according to a 2:1 randomized procedure. A total of 185 warming cycles from April 2011 to March 2013 have been analyzed. Clinical pregnancy rate an...
Article
Objective Female fertility preservation in the context of cancer management is crucial for patient's health care. The aim of this study was to evaluate the oncofertility practice at our university hospital of Montpellier since 2011. Patients and methods The evaluation of management of young patients referred to Montpellier University Hospital from...
Article
Cigarette smoking is associated with lower fecundity rate, adverse reproductive outcomes and higher risk of IVF failure. Over the last decades, prevalence of smoking among women of reproductive age has increased. The aim of this work was to focus on the knowledge of the effects of cigarette smoking on all reproductive stages, from oocyte to embryo....
Article
Cigarette smoking is associated with lower fecundity rate, adverse reproductive outcomes and higher risk of IVF failure. Over the last decades, prevalence of smoking among women of reproductive age has increased. The aim of this work was first to focus on the knowledge of the effects of cigarette smoking on reproductive stages and particularly on i...
Article
Cigarette smoking is associated with lower fecundity rate, adverse reproductive outcomes and higher risk of IVF failure. Over the last decades, prevalence of smoking among women of reproductive age has increased. The aim of this work was to focus on the knowledge of the effects of cigarette smoking on all reproductive stages, from oocyte to embryo....
Article
This review aims to evaluate whether severe endometriosis has an impact on the outcome of in vitro fertilisation (IVF), whether IVF is associated with specific complications in this context, whether a specific ovarian stimulation protocol is most appropriate, whether the endometrial condition progresses following ovarian stimulation, and whether en...
Article
Epidemiological evidence clearly shows that obesity contributes to menstrual disorders, infertility and poor pregnancy outcome. Clinicians face two problems: obesity-related infertility and, consequently, obesity in women using assisted reproductive technologies. Whereas weight loss constitutes the first-line therapy for the former, the same does n...

Citations

... However, some pregnant women have high blood sugar in the early stages of pregnancy due to a missed diagnosis of pregestational diabetes mellitus (PGDM), which has a high prevalence in China [7,8]. Early screening for GDM is recommended for pregnant women with risk factors to improve pregnancy outcomes [9][10][11][12][13][14]. ...
... Artificial shrinkage (AS) of the blastocoel by different methods-laser pulse, microneedle, micropipetting, and 29-gauge needle was developed with the idea of overcoming this obstacle. A study by Gala et al. in 2014 encompassing 185 warming cycles reported a higher survival rate after AS (99.0%) compared to 91.8% survival rate in the control group without AS [46]. Darwish and Magdi in 2016 assessed clinical pregnancy rates, implantation rates, and blastocyst survival rates in more than 400 patients, divided into two groups-untreated expanded blastocysts and blastocysts undergone AS by laser pulse [47]. ...
... Nowadays, due to new treatment options and substantially improved diabetic control there is a continuous increase of women with type 1 diabetes getting pregnant, reaching term and delivering healthy newborns. Although complications decreased, C-Sections (CS) rates remain high, exceeding 60% [1][2][3][4][5]. As a vaginal delivery is the most desired birth experience in the vast majority of women, this obvious disproportion compared to healthy non-diabetic women is extremely relevant. ...
... After adjusting for confounding factors, BMI also did not affect the miscarriage rate. A limitation of the study was the decreased number of women with a BMI over 35 kg/m2 and over 40 kg/m2 [10]. While analyzing the results of 1654 ICSI cycles, BMI did not significantly impact ART outcomes. ...
... In a sibling cohort study of recipient cycles, similar embryo development has been shown from fresh vs. vitrified oocytes (13). Several well-controlled studies involving donor oocytes have shown that clinical outcomes with vitrified oocytes are comparable to those with fresh oocytes (7,(14)(15)(16). A large study of a donation program reported by Cobo et al. has demonstrated comparable obstetric and perinatal outcomes from vitrified vs. fresh oocytes (17). ...
... miRNAs miRNAs are small RNA molecules that circulate in biological fluids, such as in serum, plasma and other body fluids [75]; however, they have not been studied in terms of their contribution to female infertility or IVF. A study by Scalici et al. [76] suggests that these miRNAs may serve as new biomarkers for IVF patients, allowing for more individualized treatment. This study found that the expression of circulating miRNAs differed depending on the women's ovarian reserve status, gonadotropin treatments, and/or the outcome of IVF [76]. ...
... This effect makes FSH secreted in high amounts to stimulate more oocytes to grow, which appears in the positive correlation between cfDNA and FSH. CfDNA level is found to be higher in follicles from females with low ovarian reserve, as compared to females with normal ovarian reserve [20]. The high basal FSH levels [days 2-3 of the menstrual cycle] is associated with low production of oocytes and, so, the increase of cfDNA concentration may give indication of the number and the quality of oocytes pick up [5]. ...
... The mechanisms are still not well understood. It has been found that female aging alters the expression of variety of genes in human cumulus cells being essential for oocyte quality and potential targets of specific miRNAs previously identified in cumulus cells, such as miR-425, miR- 744, miR-146b, and Let-7d for younger (<30 years) and middle-aged (31–34 years) women and miR-202 and Let-7e for elder (>37 years) women [41]. ...
... trospective studies predominate over only three prospective studies. In a meta-analysis (Boyard et al., 2020), the authors identified 85 publications that included artificial collapse over a 14-year period up to the first quarter of 2018. They selected eight studies of sufficient quality to be included in the meta-analysis (Darwish and Magdi, 2016;Gala et. al., 2014;Iwayama et al., 2011;Kovačič et al., 2018a;Levi-Setti et al., 2016;Mukaida et al., 2006;Vanderzwalmen et al., 2002;Van Landuyt et al., 2015), among which only three comparative studies reported live birth rate (LBR) as an outcome (Gala et al., 2014;Kovačič et al., 2018a;Levi-Setti et al., 2016). The results of this meta-analysis showed t ...
... A previous French regional study conducted in 2012 reported that 54% of oncologists had never referred a patient for a FP specialized consultation before cancer treatment [23]. These data are concordant with the low FP activity of a French regional referential center with only 71 patients referred in 2 years [28]. Indeed, 58% of a cohort of French oncologists declared themselves to be not sufficiently trained in oncofertility [23]. ...