C Bartolozzi’s research while affiliated with University of Pisa and other places

... It has been reported that sorafenib demonstrated better antitumor effects when it was coadministered with 5fluorouracil (FU) in patients with advanced solid tumors. 15,16 Regorafenib (REG) is an analogue of SOR in terms of both molecular structures and pharmacological mechanisms. Replacing one hydrogen of SOR with fluorine leads to REG ( Figure 1). ...

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An Elusive Drug–Drug Cocrystal Prepared Using a Heteroseeding Strategy

... Seven RCTs compared RFA with PEI. 29,33,37,39,[43][44][45] RFA appeared to be more effective than PEI in most studies that reported OS (4/6 RCTs favoured RFA), event-or cancer-free survival (3/3 RCTs) and recurrence or local tumour progression (5/6 RCTs); all studies favouring RFA had a low RoB or some RoB concerns. However, some studies reported worse adverse events after treatment with RFA. ...

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The effectiveness of ablative and non‐surgical therapies for early hepatocellular carcinoma: Systematic review and network meta‐analysis of randomised controlled trials

... Magnetic resonance imaging (MRI) is a cornerstone in medical diagnostics, providing high-resolution images of soft tissues with unparalleled contrast. In abdominal imaging, MRI plays a crucial role in diagnosing and monitoring various abdominal conditions and anomalies such as liver cirrhosis, pancreatic tumors, and renal anomalies [5,7,9,10,18]. However, traditional MRI scans often produce anisotropic data, where the resolution differs across spatial dimensions, potentially limiting diagnostic accuracy and the ability to perform precise volumetric analysis [4,21]. ...

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SIMPLE: Simultaneous Multi-Plane Self-Supervised Learning for Isotropic MRI Restoration from Anisotropic Data

... A careful follow-up protocol is recommended after HCC ablation aiming to detect any recurrence of treated lesion and possible new lesions' development in other parts of the liver. A standard protocol for the follow-up should include at least a spiral CT or dynamic MR study of the liver every 4-6 months [48]. In the present work, triphasic CT was done every 3-6 months for the first 1.5 years after ablation. ...

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Radiofrequency ablation combined with percutaneous ethanol injection in patients with hepatocellular carcinoma

... The standard MRI protocol contains the following sequences: axial T2, axial T1 in-phase and out-of-phase, fat-suppressed T2-weighted, diffusion weighted imaging (DWI) with corresponding apparent diffusion coefficient map, which includes both morphological and functional features of the lesion, and volumetric T1-weighted precontrast and dynamic volumetric post-extracellular contrast sequences, to contain at least an arterial and portal venous phase [25]. However, the European Society of Gastrointestinal and Abdominal Radiology has recommended use of liver-specific contrast agents, including gadobenate dimeglumine (Gd-BOPTA) and gadoxetic acid (Gd-EOB-DTPA, Primovist®) [26]. Studies have found that gadoxetic acidenhanced MRI detected additional lesions, when compared to extracellular gadolinium-enhanced MRI scans [27 •, 28, 29]. ...

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Current Management of Neuroendocrine Tumour Liver Metastases

... Even though RFA has replaced PEI because of superior and predictable ablative results, the two methods are equally effective in small tumors (< 2 cm) [43, 104, 105]. PEI can be offered in small HCCs, mainly those for which RFA is not feasible due to tumor location (e. g. adjacent to the gallbladder, hepatic hilum, or large vessels) [106]. Another chemical ablation technique, percutaneous acetic acid injection (PAI), has not offered substantial advantages over PEI [107]. ...

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EFSUMB Guidelines on Interventional Ultrasound (INVUS), Part III

... In our previous studies, we found that angiotensin I production was transiently increased, peaking at approximately 2 weeks and returning to baseline levels after 6 weeks (Warner et al., 2012). A similar transient elevation of plasma angiotensin I production has been observed in human RAS (Garovic and Textor, 2005;Safian and Textor, 2001). It is likely that, as severe renal atrophy develops, the STK is less capable of activating the systemic renin-angiotensin system. ...

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Development of renal atrophy in murine 2 kidney 1 clip hypertension is strain independent

... Some factors are hardly surprising, such as the time of day, the experience of the radiologist and the number of interruptions À others more puzzling, such as the size and luminescence of the screen, the use of key images in reporting, and the image order in the hanging protocol. (12)(13)(14)(15)(16)(17)(18) Given this complexity, it does not seem unreasonable to assume that the reading times when using AI can be differently affected in a clinical environment and a research environment. This seems supported by studies which find that CAD findings affect the reading times of individual radiologists differently. ...

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Impact of Concurrent Use of Artificial Intelligence Tools on Radiologists Reading Time: A Prospective Feasibility Study

... Where i, j represents voxels in corresponding image datasets in the domain defined as M [21]. This method is mainly used for two similar image datasets. ...

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Evaluation Method for the Optimization of 3D Rigid Image Registration of Multimodal Image Datasets

... Прежде всего, пациенту с ХАГ необходимо рекомендовать уменьшение потребления соли и включение в ежедневный рацион достаточного количества фруктов и овощей. Эпидемиологические исследования показывают, что употребление маринованных, ферментированных, обработанных или копченых продуктов с высоким содержанием нитритов и нитрозаминов [24], пищи, приготовленной методами с использованием высоких температур, такими как гриль или жарка, приводящими к высвобождению гетероциклического амина [25,26], а также диеты с повышенным содержанием гемового железа, красного мяса [27] или насыщенных жиров могут способствовать развитию и прогрессированию РЖ [28]. Курение табака и употребление алкоголя также являются дополнительными факторами риска РЖ и могут синергически взаимодействовать с факторами питания и инфекцией H. pylori. ...

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Clinical supervision of chronic atrophic gastritis