Brygida Knysz's research while affiliated with Wyższa Szkoła Handlowa we Wrocławiu and other places
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Publications (121)
Cutaneous larva migrans (CLM) is a dermatosis caused by accidental infestation with animal hookworms and is widely distributed in tropical and subtropical regions. Humans become infected when their skin comes into contact with soil contaminated with dog faeces. The filariform larvae penetrate and burrow into human skin, causing a condition known as...
Introduction: Inflammation and injury within reproductive organs, including artificial vagina, can facilitate human immunodeficiency virus (HIV) transmission. However, HIV infection in a patient with Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome has been rarely described. Both MRKH and HIV diagnoses are linked to psychological distress in patients...
Background:
Since the beginning of the coronavirus disease (COVID-19) pandemic, numerous infections have been observed with various symptoms and degrees of severity. Not all patients have had a confirmation of infection made using reverse transcription polymerase chain reaction (RT-PCR) or antigen tests. It has been observed that some people, incl...
The COVID-19 pandemic underlines the importance of targeting the groups with the highest risk of vaccine hesitancy, understanding their fears, and alleviating them. As the pandemic situation is very dynamic due to the appearance of new SARS-CoV-2 variants, concerns might also change over time. This is the first study to evaluate the vaccination rat...
Since the end of December 2020, it has been possible to vaccinate against COVID-19. Our aim was to evaluate and compare the effectiveness of the vaccines available at the time of the mass vaccination program in Poland and also to look into the most common adverse side effects. Patients' anti-SARS-CoV-2 antibodies levels were checked before vaccinat...
The use of combined antiretroviral therapy (cART) inhibits the replication of the Human Immunodeficiency Virus (HIV) and thus may affect the functioning of the immune system, e.g., induce changes in the expression of certain cytokines. The aim was to examine the effect of cART on the expression of selected cytokines: interleukin -4, -7 and -15 in H...
Subjects infected with human immunodeficiency virus (HIV) treated with combined antiretroviral therapy (cART) show a greater predisposition to metabolic disturbances compared to the general population. The aim of the study was to assess the effect of cART on the level of selected parameters related to carbohydrate and lipid metabolism, cardiovascul...
Human Immunodeficiency Virus (HIV) infection and the chronic use of combined antiretroviral therapy (cART) may affect the occurrence of certain disturbances in the body. There is growing interest in sirtuins–enzymes involved in the regulation of many metabolic processes in the organism and in the pathogenesis of many diseases which also exhibit pot...
Objectives
Although direct-acting antivirals (DAAs) can clear HCV in nearly all HIV/HCV-coinfected individuals, high rates of reinfection may hamper efforts to eliminate HCV in this population. We investigated reinfection after sustained virological response (SVR) in HIV/HCV-coinfected individuals in Europe.
Methods
Factors associated with odds of...
Objectives
The aim of this study was to assess the impact of hepatitis B virus (HBV) infection on non-liver malignancies in people living with HIV (PLWH).
Methods
All persons aged ≥ 18 years with known hepatitis B virus (HBV) surface antigen (HBsAg) status after the latest of 1 January 2001 and enrolment in the EuroSIDA cohort (baseline) were incl...
![Figure 1. Scheme of interaction of SIRT1 1 with viral protein Tat [12]....](publication/355231828/figure/fig1/AS:1079308554633218@1634338620845/Scheme-of-interaction-of-SIRT1-1-with-viral-protein-Tat-12-Deacetylation-of-Tat-by_Q320.jpg)
The sirtuins (SIRTs) are a family of enzymes from the group of NAD+-dependent deacetylases. Through the reaction of splitting the acetyl group of various transcription factors and histones they regulate many processes in the organism. The activity of sirtuins is linked to metabolic control, oxidative stress, inflammation and apoptosis, and they als...
Poland is among the European countries currently facing the second wave of the SARS-CoV-2 pandemic. A lot of studies confirm the mortality rate of COVID-19 increases with age. Considering the particularly adverse outcomes of a SARS-CoV-2 infection, preventing infections should be the priority for public health professionals. One method for preventi...
Background
This study analysed the NS3 and NS5A mutation frequencies, persistence and drug susceptibility in a cohort of real-life patients, with failed hepatitis C virus (HCV) therapy following directly acting antiviral (DAA) treatment.
Methods
NS3/NS5A Sanger sequences from 105 patients infected with HCV genotype (G) 1a (6,5.7%), G1b (94,89.5%),...
Introduction
For years, there has been an increase in the number of cases of chronic kidney disease (CKD) in human immunodeficiency virus (HIV)-infected patients. Renal dysfunction can be caused by direct effects of HIV on the kidneys but also of applied combined antiretroviral therapy (cART). Therefore there is a need of renal function diagnosis t...
In December 2019 the first cases of atypical pneumonia caused by a novel coronavirus SARS-CoV-2 were reported in Wuhan, China. This new infection was called coronavirus disease 2019 (COVID-19). SARS-CoV-2 is primarily transmitted human-to-human via direct contact and via the air-respiratory droplets and/or aerosols. The clinical manifestations of C...
Background:
The aim of this study was to determine the consumption of specific food groups by people with HIV and to determine the quality of their diets.
Objectives:
To assess the relationship between selected eating habits and lifestyles of people infected with HIV. The research was conducted at the HIV/AIDS Preventative and Therapeutic Clinic...
Covid-19 is caused by a new virus and no effective therapy is available. The following article
presents the case of a 47-year-old woman with SARS-CoV-2 infection. The infection was initially
mild but because of exacerbation of the symptoms: cough, fever, headache, extreme weakness
she was admitted to the hospital. The chest X-ray revealed pneumonia...
Background:
Zoonotic onchocerciasis is a vector-borne disease, which involves many animal species, including large ungulates, boars, dogs, and sporadically, humans. So far, 39 cases of zoonotic onchocerciasis have been reported worldwide, 30 of which have been found in the last 20 years. Onchocerca nematodes are transmitted to humans by blood-suck...
Aim of the study:
This multicentre study aimed to examine the actual risk for drug-drug interactions in a cohort of Polish patients, and their impact on antiviral therapy.
Material and methods:
Concomitant medications were analyzed in hepatitis C virus (HCV)-infected patients treated with still valuable therapy with OBV/PTV/r ± DSV ± RBV. An est...
Introduction:
Used antiretroviral therapy in HIV-patients can lead to disturbances in the proper functioning of the kidneys. Renal dysfunction can also be caused by the direct effects of HIV on the kidneys. There is a need for renal function diagnostics to monitor the development of chronic kidney disease in this patients.
Objectives:
The aim of...
Introduction: Human immunodeficiency virus (HIV) infection remains an important health problem despite the fact that combined antiretroviral therapy (cART) prolongs life and protects against acquired immunodeficiency syndrome (AIDS). Chronic kidney disease is an important cause of mortality among HIV patients, co-monitoring of renal function and mo...
Introduction: Metabolic syndrome has become an important issue affecting the long-term prognosis of human immunodeficiency virus (HIV) patients in the context of cardiovascular disease. The aim of the study was to determine whether the amount and quality of dietary fats consumed had an effect on total, low-density lipoprotein (LDL) and high-density...
Introduction: The aim of this study was to investigate brain bioelectrical activity disturbances in HCV-positive patients before and 24 weeks after interferon-free therapy (DAA), using visual (VEP) and brainstem (BAEP) evoked potentials and advanced magnetic resonance techniques. Materials and methods: 11 HCV-infected patients (6 women, 5 men, mean...
The study was performed to evaluate cerebral volume changes in HCV-infected subjects before and after interferon-free therapy with direct-acting antiviral agents (DAA). We aimed also to estimate the impact of successful DAA therapy on the neuropsychological state of patients. Eleven HCV genotype 1 (GT1) patients treated with ombitasvir/paritaprevir...
The purpose of this study was to assess cerebral microstructural and perfusion changes in patients with chronic hepatitis C virus (HCV) infection before and after interferon‐free therapy, using advanced magnetic resonance (MR) techniques. Eleven HCV‐positive patients underwent diffusion tensor imaging (DTI) and perfusion weighted imaging (PWI) usin...
![Table 1 . Characteristics of the study group ([27], modified)](profile/Weronika-Rymer/publication/329979139/figure/tbl1/AS:709003831177218@1546051094457/Characteristics-of-the-study-group-27-modified_Q320.jpg)
Introduction: Chronic kidney disease in one of the significant chronic conditions in human immunodeficiency virus (HIV)-infected population. The nephrotoxicity of antiretroviral therapy, particularly tenofovir disoproxil fumarate, is the important cause of kidney function impairment. There is a need to find reliable markers of early kidney damage....
Background:
The percentage of people living with undiagnosed HIV infection remains very high in Poland and exceeds 50% - one of the highest rates in Europe. At the same time, the number of HIV tests performed by medical doctors per 1000 inhabitants is the lowest in Europe. Thus, every effort should be made to keep diagnosed patients in care. Howev...
Objectives:
We assessed differences in antiretroviral treatment (ART) coverage and virological suppression across three HIV key populations, as defined by self-reported HIV transmission category: sex between men, injection drug use [IDU] and heterosexual transmission.
Design:
Multinational cohort study.
Methods:
Within the EuroSIDA study, we a...
The implementation of highly active antiretroviral therapy has increased the life expectancy of people living with human immunodeficiency virus (HIV), thus reducing the number of deaths from acquired immune deficiency syndrome. Nowadays life expectancy of HIV(+) patients is comparable to those who are not infected. However, due to the use of antire...
The family Flaviviridae includes arthropod-borne viruses that are transmitted to vertebrates by infected mosquitoes and ticks. There are over a 100 species in this family, most of which are animal pathogens, although it cannot be excluded that some animal flaviviruses will also cause human disease. The family name is due to the discovery of the yel...
Correlation between TF and TFPI in study group (SG) and control group (CG).
(TIF)
Abstract
Introduction
HIV infection is associated with an increased risk of cardiovascular disease in connection with atherosclerosis and thromboembolic complications. The pathogenesis of atherosclerosis is still unclear in this group of patients. Studies on pathogenesis of atherosclerosis in the general population emphasize the role of the extrins...
Study group, comparison of subgroups with TF<450pg/ml and >450pg/ml.
(PDF)
Maximum likelihood tree showing the indentified clusters marked in blue.
Clusters ≥ 5 sequences shaded in grey. All clustered sequences were used for the MCMC analysis using beast.
(PDF)
Introduction
Reconstruction of HIV transmission links allows to trace the spread and dynamics of infection and guide epidemiological interventions. The aim of this study was to characterize transmission networks among subtype B infected patients from Poland.
Material and methods
Maximum likelihood phylogenenetic trees were inferred from 966 HIV-1...
Histograms presenting distributions in time between the dates of infection for the clustered sequences for all (a) sequences/pairs, (b) clusters ≥ 5 sequences, (c) clusters of 2–4.
(TIF)
Introduction: Human immunodeficiency virus (HIV)-associated lipodystrophy syndrome (LS) is defined as a redistribution of adipose tissue, metabolic and endocrine abnormalities, resulting from combined antiretroviral therapy (cART). Aim of this study was to evaluate LS in HIV-infected patients from Lower Silesia, Poland.
Material and methods: One hu...
Introduction: Despite a great progress in antiretroviral therapy (ARV) there are many human immunodeficiency virus (HIV)-infected patients with lipodystrophy syndrome (LS). However, there are still no clearly defined criteria to diagnose dystrophic changes. It would be valuable to introduce a non-invasive and inexpensive method to clinical practice...
Virologic and safety outcomes of ombitasvir/paritaprevir/ritonavir ± dasabuvir ± ribavirin (OBV/PTV/r±DSV±RBV) therapy have shown high sustained virologic response (SVR) rates and good tolerability in most patient populations in pre-registration studies. This multicenter study was designed to confirm these clinical trial findings in HCV genotype 1...
Cryptosporidium is an opportunistic protozoan parasite that can cause severe diarrhoea in immunocompromised patients. The transmission of this pathogen in humans and animals is not fully understood. C. meleagridis, originally described in birds, is the only Cryptosporidium species known to naturally infect mammalian and avian species. This study do...
INTRODUCTION Chronic kidney disease (CKD) is one of the consequences of human immunodeficiency virus-1 (HIV-1) infection. It increases the risk of progression to acquired immunodeficiency syndrome and death and complicates antiretroviral therapy. The prevalence of CKD in HIV-1-infected patients is difficult to estimate and depends on the diagnostic...
Introduction: Clinical trials proved that treatment with ombitasvir/paritaprevir/ritonavir ± dasabuvir ± ribavirin (OBV/PTV/r ± DSV ± RBV) is effective and well tolerated. AMBER is a multicentre, open-label, investigator-initiated study conducted to assess the efficacy
of OBV/PTV/r ± DSV ± RBV in “real-world” setting. Material and methods: A total...
Blastocystis hominis is the most common unicellular parasite found in human faeces. Blastocystis have been isolated from many species of animals including mammals and birds. Little is known about transmission and molecular mechanisms of pathogenesis for this parasite. The clinical symptoms of B. hominis infection are nonspecific and include abdomin...
Background:
Occupational risk of blood-borne infections is investigated mostly among nurses and doctors, studies concerning non-clinical health personnel (nCHP) being rare. The analysis of the occupational exposure to the hepatitis B virus (HBV) infection and the history of vaccination against the HBV in the nCHP group has been the aim of the stud...
Killer cell immunoglobulin-like receptors (KIR) are the most polymorphic receptors of natural killer (NK) cells. Their activity diversifies the functions of NK cells in the antiviral immune response, so the presence of certain KIR may affect transmission of HIV-1. The aim of the study was to evaluate the influence of KIR genes on the susceptibility...
Aim Complex genetic diagnosis of seronegative (HIV-) long-term partner of female patient with AIDS C3 in the context of HIV transmission. Case report and literature review. Background HIV infection was excluded in 47-year-old man, a long-term sexual partner of female patient diagnosed with AIDS C3. The risk of HIV infection was estimated as high. O...
Aim:
To evaluate daclatasvir vs telaprevir, each combined with peginterferon alfa-2a/ribavirin (pegIFN/RBV), in treatment-naive hepatitis C virus (HCV) genotype (GT) 1-infected patients.
Methods:
In this phase 3, randomized, open-label, noninferiority study, 602 patients were randomly assigned (2:1) to daclatasvir vs telaprevir, stratified by IL...
Significant survival prolongation in HIV-infected patients due to effective antiretroviral therapy is connected with increasing prevalence of chronic non-infective diseases in this population, among them chronic kidney disease. The pathogenesis of kidney disease in the setting of HIV includes conditions specific for HIV infection: direct effect of...
Haemophilia is an entity, wherein the HCV infection rate is greater than in the general population and ranges between 70-90%. The majority of HCV infections were acquired by hemophiliacs in the 1980s, by the use of infected cryoprecipitate or fresh frozen plasma preparations. It is therefore highly likely that many of them, more than twenty years a...
Telaprevir plus peginterferon/ribavirin(TPV+pegIFN/RBV) remains a therapeutic option for chronic HCV genotype(GT) 1 infection in many regions. We conducted two open-label, phase 3b trials comparing safety and efficacy of all-oral ombitasvir/paritaprevir/ritonavir and dasabuvir+/-ribavirin(OBV/PTV/r+DSV+/-RBV) and TPV+pegIFN/RBV.
Treatment-naïve(MAL...
Background:
Addiction to intravenously administered drugs has been a serious epidemiological problem for years. Among the related health complications, deep vein thrombosis (DVT) is one of the most important. This paper provides an illustrative presentation of DVT in intravenous drug users (IDUs), HIV-positive subjects among them.
Methods:
We se...
Aim of the study
The aim of the study was to analyze the incidence of adverse effects of antiretroviral therapy in patients receiving concomitant therapy with methadone substitution.
Background
With the advances in research on anti-retroviral drugs, we now have regiments with different mechanisms of action that can be combined to give an effective...
Peripheral arterial disease (PAD) is a clinical manifestation of atherosclerosis and mainly refers to elderly patients, having a negative impact on their functionality and quality of life. The findings of previous studies in HIV-infected patients have shown that cardiovascular risk is higher and PAD occurs more frequently than in the general popula...
Introduction:
EuroSIDA has previously reported a poorer clinical prognosis for HIV-positive individuals in Eastern Europe (EE) as compared with patients from other parts of Europe, not solely explained by differences in patient characteristics. We explored regional variability in self-reported HIV management at individual EuroSIDA clinics, with a...
Introduction
In Poland, the HIV epidemic has shifted recently from being predominantly related to injection drug use (IDU) to being driven by transmissions among men-who-have-sex-with-men (MSM). The number of new HIV cases has increased in the recent years, while no current data on the transmitted drug resistance associated mutations (tDRM) frequen...
A number of abnormalities related to chronic infection and antiretroviral treatment may be observed in a population of HIV-positive patients. A particular state of coexisting, interacting and interrelated disorders referred to as metabolic syndrome is observed in 7–45% of patients infected with HIV. Its presence is related to the abnormalities of a...
BACKGROUND AND PURPOSE: Asymptomatic central nervous system (CNS) involvement occurs in the early stage of the human immunodeficiency virus (HIV) infection. It has been documented that the hepatitis C virus (HCV) can replicate in the CNS. The aim of the study was to evaluate early disturbances in cerebral microcirculation using magnetic resonance (...
Introduction
The pathologic relevance of Demodex infestation in blepharitis is still controversial. The aim of the study was to determine the prevalence of Demodex spp. in eyelash follicles and its relationship to eye symptoms.
Material and methods
A total of 290 individuals were studied for the presence of Demodex folliculorum and Demodex brevis...
Most antiretroviral drugs are metabolized by the liver; hepatic disease or liver damage as a result of hepatitis C virus (HCV) could impair this metabolism leading to an increased risk of drug toxicity. This study aimed to determine the risk of antiretroviral drug discontinuation among HCV/HIV coinfected patients.
EuroSIDA patients taking combinati...
Background
This study aimed to determine Polish patients’ experiences related to receipt of positive HIV test results and to understand changes in how this information was received over time.Material and methodsAnonymous self-administered questionnaires were distributed to HIV-infected persons at support group meetings and at the Department of Infe...
The human genome contains about 8% of endogenous retroviral sequences originated from germ cell infections by exogenous retroviruses during evolution. Most of those sequences are inactive because of accumulation of mutations but some of them are still capable to be transcribed and translated. The latter are insertionally polymorphic HERV-K113 and H...
The history of HIV infection has always been associated with patient nutritional problems, initially in the form of wasting syndrome, and since the introduction of highly active antiretroviral therapy such metabolic disorders as lipodystrophy, obesity, insulin resistance, dyslipidemia that are risk factors for cardiovascular diseases have been obse...
Background & aims:
The aim of the study was to evaluate early metabolic perfusion, and microstructural cerebral changes in patients with the hepatitis C virus (HCV) infection and normal appearing brain on plain MR using advanced MR techniques, as well as to assess correlations of MR measurements with the liver histology activity index (HAI).
Meth...
