Bruno Carlesimo's research while affiliated with Università degli Studi Europea di Roma and other places

Publications (30)

Article
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Background: We would like to describe our experience with Peroneus Brevis flap in complicated Achilles tendon re-ruptures with fringed stumps. Methods: Eight patients with monolateral re-rupture of Achilles tendon were selected as eligible for surgical repair with Peroneus Brevis flap. Patients' outcome was evaluated clinically (ATRS and ROM), f...
Article
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Capsular contracture is one of the most common complications of implant-based breast augmentation. Despite its prevalence, the etiology of capsular contracture remains controversial although the surface texture of the breast implant, the anatomical position of the prosthesis and the presence of bacterial biofilm could be considered trigger factors....
Article
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Plexiform neurofibromas (PNF) occur in up to 30% of patients with neurofibromatosis type 1 (NF1). To date, management of this tumors remains medically challenging. Surgical approach represents the only viable treatment option of progressive growing plexiform neurofibromas but surgical complications may be relatively common. Intraoperative tumor ble...
Article
Deep sternal wound infection (DSWI) represents a dangerous complication that can follow open-heart surgery with median sternotomy access. Muscle flaps, such as monolateral pectoralis major muscle flap (MPMF), represent the main choices for sternal wound coverage and infection control. Negative pressure incision management system has proven to be ab...
Article
Full-text available
Purpose This study aims to evaluate the safety and efficacy of autologous aspirated and purified fat tissue injected percutaneously into the knee joint for the treatment of symptomatic osteoarthritis (OA). Methods We reviewed 30 patients, who received an autologous percutaneous fat injection for the treatment of knee OA, from January 2012 to March...
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Extensive skin defect represents a real problem and major challenge in plastic and reconstructive surgery. On one hand, skin grafts offer a practical method to deal with skin defects despite their unsuitability for several complicated wounds. On the other hand, negative pressure wound therapy (NPWT), applied before skin grafting, promotes granulati...
Article
Vacuum-assisted closure (VAC) therapy is a sophisticated system that maintains a closed, humid, sterile and isolated environment. Wound infection is considered a relative contraindication. The objective of this study is to extend the indications for VAC therapy to include infected wounds by demonstrating its ability to increase the antibiotic conce...
Article
Deep sternal wound infection (DSWI) is an uncommon but serious complication of open heart surgery being characterized by a high mortality rate and a considerable economic weight. Repair of sternal defects, compromised with infection, can be achieved in several ways. The aim of our study is to report our case load in the management of sternal wound...
Article
Muscular flaps are considered by many surgeons as a treatment of choice for pressure sores. Nevertheless fasciocutaneous and adipofascial flaps are less sensitive to ischemia, more resistant to pressure and have higher mechanical resistance. The aim of this study is to evaluate the results of our integrated rehabilitative and surgical protocol in p...
Article
AIM: We present a two stage reimplantation technique for infected total knee arthroplasty using a muscular gastrocnemious spacer that allows delivery of high local concentrations of antibiotics in absence of heterologous materials associated with high percentage of infection. MATERIAL OF STUDY: Between January 2009 and June 2011 we selected 8 patie...
Article
Vacuum-assisted closure (VAC) therapy is a closed-loop, non invasive active system, characterised by a controlled and localised negative pressure applied on porous polyurethane absorbent foams. It promotes healing of acute and chronic wounds. Therapeutic effects of VAC therapy have been proved and demonstrated; however, this method can have some di...
Article
Implant breast augmentation is one of the most frequently performed surgical procedures, and fungal infection still is considered exceptional. This report presents a case of bilateral breast implant infection by multidrug-resistant Candida albicans treated with a targeted antifungal therapy. A young woman presented with breast pain and asymmetry as...
Article
Primary incisional hernia repair is rarely successful, with recurrence rates ranging from 18% to 62%. We describe the integration of "components separation" herniorrhaphy with panniculectomy. Twenty-two patients were treated. Standard panniculectomies and component separation were performed. Intravesical pressure was measured preoperatively, intrao...
Article
Antiphospholipid syndrome (APS) is an autoimmune condition characterized by vascular thromboses and/or pregnancy morbidity in the presence of antiphospholipid antibodies. The variant "catastrophic" (CAPS) is defined as a potential life-threatening disease, characterized by multiple small vessel thromboses that can lead to multiple organ failure. Su...
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The availability of raltegravir plus atazanavir provides an alternative antiretroviral strategy that may be equally efficacious and less toxic than those currently recommended in HIV treatment guidelines. In fact, this new combination antiretroviral therapy attracts the attention of the scientific community because both drugs have a good safety pro...
Article
The use of muscle flaps is now accepted as a method for coverage of infected wounds. To obtain complete eradication of infection following hip arthroplasty surgery is combined with antibiotic treatment. Aggressive debridment to remove devitalized tissue followed by vastus lateralis muscle flap transposition may improve the likelihood of success in...
Article
The most common early complications associated with mammary implants are seroma and haematoma formation, and acute infection. The aspiration of fluid around the prosthesis can help to diagnose and correctly treat these complications. The use of a needle with a sharp tip can damage the implant. We present our experience in removing periprosthetic fl...
Article
The aim of this work was to present our experience in the use of autologous three-cellular cultured skin substitutes (CSS). This method represents a surgical alternative in the treatment of a variety of pathologies, including burns, ulcers, giant nevi and tumors. CSS were obtained from full-thickness skin biopsies collected after enrolment of 11 pa...
Article
Breast cancer represents the most prevalent malignancies in women and bone is the first site of metastasis in 26-50% of cases. Usually metastasis involve limbs in 16%. We present a rare case of 47-year-old woman, who underwent to monolateral mastectomy for lobular cancer. After 8 years from surgery, she presented pain, swelling and functional limit...
Article
Phlebostatic sore of the lower limbs is a typical chronic venous insufficiency complication and is still a widely controversial issue in its treatment. The common therapies, in fact, are not yet standardized and they not show complete efficacy. Since 2005 to 2007 a multicentric clinical trial was conducted at the Plastic and Reconstructive Surgery...
Article
Patients with squamous cell carcinoma of the lower limb may exhibit locally advanced or metastatic disease. Surgical resection to control the primary tumor is often extensive.The case of a 51-year-old man with squamous cell carcinoma on Marjolin's ulcer affected, rapidly growing, and involving soft and bone tissues is described. Treatment required...
Article
Capsular contracture is the most common complication and the main cause of dissatisfaction after augmentation mammoplasty, for both the patient and the plastic surgeon. The formation of fibrous tissue around the prosthesis alters the form or the consistency of the implant, thus modifying the breast shape, its contour and its softness. The initial s...
Article
Glomus tumors are benign neoplasms that differentiate from the glomus apparatus. This neoplasm is clinically characterized by a typical symptomatological triad: paroxysmal pain, pinpoint pain and hypersensitivity to cold. The diagnosis is usually clinical, but can be confirmed by instrumental tests such as X-ray, MRI, selective arteriography and mo...
Article
Successful treatment of prosthetic joint infections often requires multiple surgical interventions and prolonged antimicrobial therapy. However, in certain situations, a surgical approach may not be in the best interest of the patient. A conservative approach was used to treat 34 patients with prosthetic joint infection between 1995 and 2003. Diagn...

Citations

... Open-heart surgery with median sternotomy access can be followed by severe complications as heart failure, stroke and sternal bone infection (1,2). Sternal wound infection (SWI) is a complication with a great impact on costs of care and hospitalisation (3,4). ...
... We may also suppose that patients with CLI and non-healing ulcers have an immune dysfunction caused by chronic and prolonged inflammation, which also may favour progressive critical colonisation and disruptive effects of bacteria on the extracellular matrix. NPWT exerts beneficial effect in applying mechanical forces on the wound bed, 41 it shows positive effects on both the proliferation of the granulation tissue and the stimulation of extracellular matrix turnover, and it may increase the local concentration of drugs in the treated tissue enhancing their systemic effects beginning from the initial phases of treatment. 42 These hypotheses may explain the increased release of TIMP-1 at 1 month. ...
... The instrumental assessment of movement (Gait Analysis) is currently an essential analytical tool for the biomedical sector, in order to produce objective and precise evaluations of human movement and posture 1 . The biomechanical instrumental characterization of the various components of the movement (i.e., space-time, kinematics, kinetics, and surface electromyography, sEMG), as well as their variations with respect to a normal situation, are highly relevant in the clinical and research field for the diagnosis of particular conditions including one of the systems involved (neurological, musculoskeletal) 2 , as well as for the prognosis and therapeutic approach, as well as for their follow-up 3 . Biomechanical research must include a multidisciplinary approach enabling movement analysis, in order to determine the different components that generate it in order to provide a clinically relevant interpretation [4][5][6] . ...
... 37,38,[40][41][42] However, the prevailing theory is that overt pocket infection or subclinical infection from implant contamination is the predominant cause. [43][44][45][46][47][48] Additionally, several of the theories probably include a component of predisposition to implant contamination (ie, incision placement). 47,49,50 The thought is that bacterial contamination results in the formation of a biofilm. ...
... Moreover, two studies compared the use of the pectoralis major muscle flap with NPWT to the flap without NPWT in patients with deep sternal SSI after cardiac surgery. The studies reported that the NPWT had a significantly shorter ICU stay [19,20] and tended to have a shorter overall length of hospital stay [20]. ...
... These findings were in line with observed improved VAS scores and clinical outcomes. Although several studies have already shown promising results in patients with knee OA treated with intraarticular injection of adipose tissue rich in ASCs (both previously expanded or microfragmented in the operating room) associated or not to arthroscopic debridement [1,11,15,16,21,22,26,34], the use of this treatment is not yet supported by strong scientific evidence [17], especially regarding PFOA. To our knowledge, no previous studies have evaluated the effectiveness of adipose tissue knee injection in patients with isolated primary PFOA. ...
... More recently, a case series by Pichler et al 16 and a comprehensive review of 161 cases by Eisendle et al 37 showed how NPWT alone and subsequent STSG secured with NPWT can lead to successful PG healing, when associated to adequate immunosuppression. The reports described above, appear consistent with our experience and previous protocols in the management of complicated chronic wounds [38][39][40] . ...
... Surgical intervention's benefit is debated, due to possible pathergy phenomenon 13 . Negative pressure wound therapy (NPWT) may be applied in cases of ulcers 14,15 and split-thickness or full-thickness skin grafts can be used for definitive coverage 16 . ...
... In the 1980s, before the introduction of negative-pressure wound therapy dressing, 6 wound dehiscence, including primary synthesis with metal wires, titanium plates, and sternal reconstruction, using muscle or omental flaps. 14,16,26,27 The use of bilateral pectoralis major muscle flaps has had better rates of stabilisation of the chest wall than has had sternal reconstruction with metal wires. 27 Eventually, it was found that a portion of the anterior fascia of the rectus abdominis muscle could be dissected and attached to the caudal part of the pectoralis major myocutaneous flap to facilitate wound closure. ...
... Advanced wound dressings with wet compresses and saline alginate dressings demonstrated their utility 29 . On the other side, some patients may present with advanced and large lesions requiring prompt and reliable coverage 30 . In such cases, surgery would apparently represent an attractive solution. ...