Branislav Milovanovic's research while affiliated with University Children's Hospital, Belgrade, Serbia and other places
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Publications (56)
Background and Objectives: The concentration of antibodies against virus influenza A H1N1 in the titer (≥1:32) positively correlates with resistance to flu in healthy persons. In elderly and immune-compromised patients, an influenza vaccine may be less immunogenic. Hypothesis: A lower post-vaccinal antibody titer (≥1:16) may be sero-protective agai...
Background
We are facing the outburst of coronavirus disease 2019 (COVID-19) defined as a serious, multisystem, disorder, including various neurological manifestations in its presentation. So far, autonomic dysfunction (AD) has not been reported in patients with COVID-19 infection.
Aim
Assessment of AD in the early phase of infection with severe a...
The world has faced a coronavirus outbreak, which, in addition to lung complications,
has caused other serious problems, including cardiovascular. There is still no explanation for
the mechanisms of coronavirus that trigger dysfunction of the cardiac autonomic nervous system
(ANS). We believe that the complex mechanisms that change the status of AN...
Due to their great importance in science, technology, and the life sciences, water and ice have been extensively investigated over many years. In particular, hexagonal ice Ih has been of great interest since it is the most common form of ice, and several modifications, Ih(a), Ih(b) and Ih(c) are known, whose structural details are still under discu...
Baroreceptor reflex (baroreflex, BRR) is a domineering physiological regulator considering the systolic blood pressure (SBP) and heart rate (HR). It maintains the negative feedback equilibrium: if the blood pressure increase, heart rate decreases and vice versa. The aim of this study is to compare the number of baroreflex sequences in hypertensive...
Baroreflex is considered to be the dominant physiologic parameter between systolic blood pressure (SBP) and heart rate. This mechanism maintains physiological equilibrium using negative feedback: if blood pressure tends to rise, heart rate lowers and opposite. The aim of this study was to compare RR intervals and SBP, parallel and antiparallel stre...
Power spectral density estimation (psd) of the heart rate signal (HR) indicates the activity of the autonomic nervous system. The lack of standard contributed to the selection of various methods for psd estimation such as classical nonparametric (periodogram, Welch), parametric (Burg method) and the proposed new methods designed especially for psd...
Cardiovascular signals are characterized by spontaneous fluctuations described more than a thousand years ago. Their physiological meaning is largely explained and it represents one of the most important groups of signals used to describe the state of the human organism. This paper analyzes the RR interval and blood pressure signals in patients usi...
In this paper we analyze fundamental foundations of Internet of Everything (IoE) and their realizations considering the medical applications. A special attention is devoted to the database creation, where the inputs are signals that volunteers collect during their everyday activities, and then discard due to the memory limitations. The collected da...
In this paper we analyzed cardiovascular parameters recorded from patients with diagnosis of myocardial infarction and healthy individuals in a control group. The aim was to develop model for solving a problem of binary classification, myocardial infarction risk prediction and parameter’s influence on decision of class affiliation. The paper presen...
In this conference paper we analyze fundamental foundations of Internet of Everything (IoE) and their realiisaation considering the medical applications. A special attention is devoted to the database creation, where the imputs are signals that voluteers collect during their everydaz activities, and then discard due to the memory limitations. The c...
Mobile crowd sensing (MCS) is an application that collects data from a network of conscientious volunteers and implements it for the common or personal benefit. This contribution proposes an implementation that collects the data from hypertensive patients, thus creating an experimental database using the cloud service Platform as a Service (PaaS)....
Machine learning techniques rely on a set of input features in order to group the patients into the similar groups, based on the predefined criteria. The aim of this study is to investigate relationship among the cardiovascular features that are the most relevant for patients with diabetes. The cardiovascular time series are recorded from 28 patien...
This study gives a survey of several machine learning techniques applicable in the cardiovascular examination. The aim is to model the complex relationship between the chosen cardiovascular parameters in the group of patients after myocardial infarction and the control group. The possibility to solve the problems of classification, prediction, reli...
The Internet of Things (IoT) is a concept that integrates the physical world into the computer-based systems. Mobile crowd sensing (MCS) is singled out as an application that collects data from a network of conscientious volunteers and implements it for the common and personal benefit. The implementation proposed in this work collects the informati...
This paper examines an impact of artifacts considering
the power spectrum density of R-R intervals and related
analytical parameters. Spectral components are
estimated using the periodograms, the modified Weltch
periodograms and the Burg AR method, implementing
different parameters (window length and window
overlap), order and resampling frequency...
Objectives:
Antiphospholipid syndrome (APS) may manifest itself as a primary (PAPS) or secondary disease, most commonly in the context of systemic lupus erythematosus (SLE) with various neurological and cardiac manifestations in its occurrence. The objective of this study was to investigate the relationship between cerebrovascular (stroke and tran...
Portapres ® is a unique device that reliably accomplishes a challenging task of continuous and non-invasive recording of blood pressure (BP) waveforms in moving subjects. The complex procedure of Portapres ® signal acquisition includes periodic changes of cuffed fingers to avoid pain and stress, as well as the blood pressure correction due to the i...
Cross-approximate entropy (XApEn) quantifies the mutual orderliness of simultaneously recorded time series. Despite being derived from the firmly established solitary entropies, it has never reached their reputation and deployment. The aim of this study is to identify the problems that preclude wider XApEn implementation and to develop a set of sol...
Artificial neural networks (ANNs) are machine learning technique, inspired by the principles found in biological neurons. This technique has been used for prediction and classification problems in many areas of medical signal processing. The aim of this paper was to identify individuals with high risk of death after acute myocardial infarction usin...
Objectives:
Personalised monitoring in health applications has been recognised as part of the mobile crowdsensing concept, where subjects equipped with sensors extract information and share them for personal or common benefit. Limited transmission resources impose the use of local analyses methodology, but this approach is incompatible with analyt...
Introduction. Myxoma is the most common primary benign heart tumor. The most frequent location is the left atrium, the chamber of the heart that receives oxygen-rich blood from the lungs. Myxomas usually develop in women, typically between the ages of 40 and 60.Symptoms may occur at any time, but most often they are asymptomatic or oligosymptomatic...
To investigate autonomic nervous function in patients with a diagnosis of gastroesophageal reflux disease (GERD).
The investigation was performed on 29 patients (14 men), aged 18-80 years (51.14 ± 18.34), who were referred to our Neurocardiology Laboratory at the Clinical and Hospital Center "Bezanijska Kosa" with a diagnosis of GERD. One hundred s...
Epidemiological studies have shown a positive association between intake of foods rich in antioxidants and lower incidence of cardiovascular disease development. Polyphenols are considered the most abundant and important dietary antioxidants. The aim of this study was to evaluate effects of polyphenol-rich chokeberry juice consumption on 24-h ambul...
Aim. To assess the correlation between left ventricle remodeling induced by physical training with QTc duration in preadolescent professional football players. Material and methods. Ninety-four highly trained male footballers (mean aged 12,85±0,84) competing in the Serbian Football League (at least 7 training hours/ week) and 47 age-matched healthy...
The report presents a case of a 46-year-old male patient, previously treated because of dysphagia, pyrosis, vertigo while standing up and impotency. Manometric and pH-metric analysis showed presence of gastroesophageal reflux disease (GERD) caused by transient relaxation of lower esophageal sphincter (TRLES). Heart-rate variability showed decreased...
This paper introduces a set of formulae for automatic evaluation of threshold level rTEOR for which the cross-entropy of systolic blood pressure (SBP) and pulse interval (PI) (Cross-ApEn) reaches its maximum. A mathematical method for estimating the level of consistency of entropy estimates is established as well. These two methods jointly determin...
We investigated the effects of bisoprolol and losartan on subjects with essential hypertension, by conducting heart rate variability (HRV) analysis of ECG signals. Our intention was to establish the set of linear and nonlinear heart rate variability parameters, which could be used as a noninvasive markers in the treatment of hypertension.
Sixty sub...
Background:
Psychosocial stressors either acute or more sustained frequently precede the onset and exacerbation of the symptoms of the functional dyspepsia (FD). Depressive mood and quality of life have been already reported for interference in functional dyspepsia suffering patients.
Methods:
The examination were performed on 60 FD patients (30...
Brugada syndrome is an arrhythmogenic disease characterized by coved ST segment elevation and J point elevation of at least 2 mm in at least two of the right precordial ECG leads (V1-3) and ventricular arrhythmias, syncope, and sudden death. Risk stratifications of patients with Brugada electrocardiogram are being strongly debated.
A 23-year-old ma...
Reduced baroreflex sensitivity (BRS), decreased heart rate variability (HRV) and increased blood pressure (BP) variability have serious consequences for target organ damage in patients with hypertension, beside the BP level. The study was aimed to evaluate acute and long-term effects of enalapril, on BRS and HRV in individuals with prehypertension...
To investigate and compare efficacy and differences in the nutritional status evaluation of gastroenterology patients by application of two methods: subjective global assessment (SGA) and nutritional risk index (NRI).
The investigation was performed on 299 hospitalized patients, aged 18-84 years (average life span 55.57 +/- 12.84), with different g...
Despite a remarkable medical progress in the field of Developmental Medicine and Child Neurology, early identification of infants at risk for permanent motor disabilities still presents challenge for both clinicians and researchers. As an indicator of cardiac autonomic control, it was shown that heart rate variability (HRV) might reflect not only s...
The manifestations of autonomic nervous system (ANS) dysfunction in autoimmune diseases have been the subject of many studies. However, the published results pertaining to such research are controversial. Sudden cardiac death due to fatal arrhythmias is frequent in patients with systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA).
To a...
Numerous studies were focused on coronary artery disease, most of them in the male population and it seems that data on gender differences in CAD were extrapolated from these studies.
The multi-center prospective study was designed to analyze gender differences in features, clinical presentation, and early in-hospital mortality in patients with acu...
The aim of this study was to investigate autonomic cardiac control in patients with amyotrophic lateral sclerosis (ALS). Fifty-five patients with sporadic ALS (28 female and 27 male; average age 56.00 +/- 10.34 years) were compared to 30 healthy controls (17 female and 13 male; average age 42.87 +/- 11.91 years). Patients with previous history of c...
Ventricular arrhythmias (VAs) are common pediatric rhythm disorders requiring comprehensive laboratory evaluation. Although usually idiopathic, implying a benign character and favorable prognosis, the initial clinical approach is still not established in all cases. Considering their prognostic significance, exercise-induced (precipitated or aggrava...
Cardiovascular autonomic modulation is altered in patients with essential hypertension.
To evaluate acute and long-term effects of amlodipine on cardiovascular autonomic function and haemodynamic status in patients with mild essential hypertension.
Ninety patients (43 male, mean age 52.12 +/- 10.7) years with mild hypertension were tested before, 3...
Patients with liver cirrhosis have autonomic dysfunction and complex cardiovascular changes. Increases risk for sudden cardiac death (SCD) was recently recognized in liver cirrhosis. This study analyzed risk predictors for SCD related to autonomic dysfunction in patients with alcoholic liver cirrhosis (ALC). Twenty five patients with ALC were exami...
The paper considers the heart rate variability from the fractal and multifractal standpoints. The short-term inter-beat intervals for arrhythmia patients, recorded before, after and during the amiodarone therapy, have been analyzed.
Patients with end-stage renal failure have high morbidity and mortality rates due to cardiovascular complications. Screening for coronary heart disease in these patients is of utmost importance. The aim of this study was to investigate the prognostic value of the dobutamine test in patients on hemodyalisis during a 5-year follow-up period.
During t...
There are different proofs about association of autonomic nervous system dysfunction, especially nonlinear parameters, with higher mortality after myocardial infarction.
The objective of the study was to determine predictive value of Poincaré plot as nonlinear parameter and other significant standard risk predictors: ejection fraction of the left v...
Complete atrioventricular block is a serious disorder, since patients may be asymptomatic. However, it is an important risk for sudden cardiac death.
A 48-year old male patient was admitted to the coronary care unit, due to recurring substernal chest pain. It was followed by fatigue, weakness and confusion, it lasted more than half an hour and occu...
It has been shown that depolarization disorders, autonomic dysfunction, and systolic dysfunction of the left ventricle are associated with sudden cardiac death after myocardial infarction.
The objective of study was to examine the prognostic value of the most important predictors in the first week after myocardial infarction.
Study included 881 pat...
Citations
... Patients with systemic autoimmune diseases are at increased risk of influenza and severe respiratory complications, particularly if they are on therapy with immunosuppressive drugs belonging to the biological and synthetic last-generation drug classes [1][2][3]. Respiratory tract infections are the most common in this patient setting; among them, seasonal influenza remains one of the most frequent causes of hospitalization and mortality, similar to that observed in the general population [1,[4][5][6]. ...
... COVID-19 disease can cause depression, anxiety and impair autonomic functions (10,11). Dale and colleagues' large scale survey in the US showed that people diagnosed with COVID-19, and particularly medical providers, experienced increased autonomic reactivity that was associated with prior adversities and current mental difficulties. ...
... Several promising ECG analytical approaches may influence this field in the future. ECG analysis using the Lempel-Ziv complexity model [48], nonlinear analysis [49], mode decomposition and wavelet analysis [50], topological approaches [51], and entropy analysis [52] report similar levels of reliability, validity, and accuracy to the LF/HF analysis presented in this paper [18]. Although it is beyond the scope of this paper to review each analytical approach, these technologies are already offering accurate diagnostic classification of the ECG signal. ...
... K-point meshes of 8 × 8 × 8 Monkhorst-Pack scheme have been used. Chosen LCAO/Gaussian basis set type approach and DFT methods have been shown highly efficient and precise in our previous theoretical studies [44][45][46] and in comparison to the experimental data [30,47,48]. A computational strategy implemented in the CRYSTAL17 solid-state, quantum-chemical program has been performed for the accurate ab initio simulation of elastic and mechanical properties of crystalline materials [49]. ...
... Since first was proposed, HRV has been rapidly adopted as a non-invasive method to study the cardiac autonomic modulation [3]. Evidences of an association between HRV and CVD, such as myocardial infarction [4,5], stroke [6], angina [7,8], coronary heart disease [9], coronary artery disease [10][11][12] and sudden cardiac death [13], have been reported. Furthermore, studies have put forward that HRV has predictive value for CVD outcomes [14][15][16]. ...
... Lei et al. [248], by formulating the intervention tasks in real-time as a contextual bandit problem, provided an online actor-critic algorithm as an intervention strategy to guide JITAI practices. b) Crowd Sensing for Population Health: Crowd Sensing practices investigate population health issues by comprehensively mining massive health-related data among researched groups such as monitoring and screening the population health status in a region in both depth and coverage [245], [249], and verifying [87] and inferring [84] the determinants of specific diseases via powerful statistics-based approaches. ...
... Slika 5 je ilustracija promena pritiska, pulsnog intervala i telesne temperature za istog pacova kao na slikama 3 i 4, a takođe prikazuje i dinamičku zavisnost sa kašnjenjem između pulsnog intervala u odnosu na sistolni pritisak. Ovo dinamičko posmatranje uz farmakološku validaciju detaljno je elaborirano u [10] a neki aspekti su takođe prikazani u [11]. ...
... When we separated patients with arterial thrombosis according to different arterial circulation regions, we found that aPLA were statistically significantly more common in patients with ischemic stroke and TIA than in subjects who had not experienced thrombotic complications or experienced other thrombotic complications. Djokovic et al. found that APS subjects who experienced cerebrovascular thrombotic complications were more likely to be diagnosed with IgG β2GP1 antibodies than those who had not experienced these complications [18]. Carmel-Neiderman et al. who studied patients with the stroke and aPLA compared these data with the healthy control group. ...
... e network is supported by three parts: contracting, bridge, and expanding paths to complete the stain separation of H (hematoxylin), E (eosin), and B (background) channels. e contracting path is used to reduce the spatial dimension of the feature map, while increasing the number of the feature maps layer by layer [37][38][39][40], extracting the input image as a compact feature. e bridge connects the contracting and expanding paths. is U-shaped encoder-decoder model is improved to be a multiple tasks model; besides the output of the U-net, we also use the most compact features to predict the stain color matrixes, which is combined with mean and variance of stain color values of hematoxylin, eosin, and background paths. ...
... One of the most popular guidelines for this minimum length using ApEn is N ≥ 10 m [53], which translates in this case to N ≥ 1000, in agreement with the results in this study. In order to illustrate how the ApEn statistics were computed for the most unfavorable case, N = 500, the percentage of estimated probabilities on at least 10 matches, weak criterion, was 80.17 ± 10.37, and on at least 100 matches, strong criterion, was 6.52 ± 13.01 [54]. ...