Bohdan Bybel's research while affiliated with Health Sciences Centre Winnipeg and other places

Publications (32)

Article
A matched case-control study was performed to assess the relationship between metformin use and the degree of F-18 fluorodeoxyglucose (FDG) bowel activity in diabetic patients. Seventy-seven diabetic patients referred to our department for a positron emission tomography/computed tomography study, including 45 on metformin, were compared with nondia...
Article
We report a case of a 72-year-old woman with a history of papillary thyroid cancer imaged with positron emission tomography (PET)/computed tomography (CT) because of an increased thyroglobulin level and negative whole body iodine and CT scans. A near whole body F-18 2-deoxy-D-glucose (FDG) PET/CT study showed 2 well defined metabolically active sof...
Article
Single-photon emission computed tomography (SPECT) has been a mainstay of nuclear medicine practice for several decades. More recently, combining the functional imaging available with SPECT and the anatomic imaging of computed tomography (CT) has gained more acceptance and proved useful in many clinical situations. Most vendors now offer integrated...
Article
A 63-year-old man underwent a living-related kidney transplantation secondary to Wegener granulomatosis. The early postoperative course was uneventful, and the patient was discharged with good renal function. On postoperative week 3, the patient presented with complaints of leg swelling and abundant watery discharge from the lower end of the surgic...
Article
A 48-year-old man with squamous-cell carcinoma of the left tonsillar fossa and cervical lymph node metastases was being staged before radiation and chemotherapy. The patient had periodontal disease, and extraction of 2 teeth was performed before therapy. A staging PET/CT was performed 1 week after extraction. This case demonstrates increased FDG up...
Article
Positron emission tomography (PET), once the sole province of academic medical centers, is rapidly being adopted in daily clinical practice in community hospitals and outpatient centers. It can be especially useful in oncology, cardiology, and neurology. We provide an overview of the fundamentals of PET and PET with computed tomography (PET/CT) and...
Conference Paper
PURPOSE To access the utility of performing additional Body (chest, abdomen, and pelvis) FDG-PET/CT in all patients with head and neck tumors who undergo Head and Neck PET/CT for tumor evaluation, diagnosis, or recurrence after resection. METHOD AND MATERIALS 172 consecutive PET/CT patients with known head and neck tumors (squamous cell CA 147, ad...
Conference Paper
PURPOSE To determine the role of SPECT/CT and planar images in identifying and localizing abnormalities in patients with suspected neuroendocrine tumors. METHOD AND MATERIALS A retrospective review of 24 consecutive patients with either suspected or pathology-proven neuroendocrine tumors was performed. All patients undergoing Octreotide planar who...
Article
Attenuation artefacts due to implanted cardiac defibrillator leads have previously been shown to adversely impact cardiac PET/CT imaging. In this study, the severity of the problem is characterized, and an image-based method is described which reduces the resulting artefact in PET. Automatic implantable cardioverter defibrillator (AICD) leads cause...
Article
Positron emission tomography (PET), with the use of F-18 fluorodeoxyglucose (FDG), has been shown to be useful in the evaluation of many tumors as a result of its high sensitivity and specificity. There are instances, however, in which false-positive FDG uptake can occur with inflammatory lesions or granulomatous diseases. In fact, false-positive m...
Conference Paper
PURPOSE Superficial esophageal adenocarcinomas comprise high grade dysplasia and invasive tumors confined to within the submucosa. Their early detection has significant prognostic and therapeutic implications. Presurgical staging and definition of tumor extent has relied extensively upon endoluminal ultrasonography (EUS). We compared F-18 FDG PET-C...
Conference Paper
PURPOSE Combined PET/CT scanners have greatly facilitated the registration and fusion of whole-body PET and CT images by removing common sources of misalignment: differences in body positions and orientations, and couch shapes. Breathing-related nonrigid mismatches, however, still persist, correcting for which is the goal of the present study. MET...
Article
Registration and fusion of whole-body functional PET and anatomic CT is significant for accurate differentiation of viable tumors from benign masses, radiotherapy planning and monitoring treatment response, and cancer staging. Whole-body PET and CT acquired on separate scanners are misregistered because of differences in patient positions and orien...
Article
A 67-year-old man with progressive dysphagia was recently diagnosed with a gastroesophageal junction adenocarcinoma. Contrast-enhanced CT scans of the abdomen and pelvis reported a large GE junction tumor without evidence of metastatic disease. FDG positron emission tomography revealed intense tracer accumulation in the soft tissue mass at the GE j...
Article
After 131I radioablative treatment, a 51-y-old woman underwent whole-body (131)I scanning, which revealed intense uptake along the periphery of the skull. The patient disclosed that she had not washed her hair because she had obtained a new hairstyle between the 131I treatment and the scan. The intense uptake along the periphery of the skull repres...
Article
Background: Cardiac PET/CT provides, on a single imaging platform, functional information from PET and morphological information from CT (e.g. coronary angiography). However, PET/CT employs a different technique to acquire information for attenuation correction (AC). PET scanners typically use radionuclide sources (511 keV) to acquire a 300–600 sec...
Article
Background: Rapid growth of oncologic PET imaging procedures is stimulating the use of PET/CT devices, and it would be desirable for imaging centers to also employ this technology for myocardial imaging. However, it is uncertain whether left ventricular ejection fraction (LVEF) measurements obtained from myocardial PET images using CT based attenua...
Article
Full-text available
Background: Ability of patients (pts) to perform a regular symptom-limited exercise treadmill test (ETT) is well-known favourable predictor of prognosis. However, prognostic impact of the ability to perform an adjunctive low-level exercise (Adeno-Walk) in pts referred to adenosine (Adeno) stress myocardial perfusion SPECT (MPS) has not been defined...
Article
We report an algorithm for automatic elastic registration of whole body computed tomography (CT) and positron emission tomography (PET) images, which would allow accurate localization of viable tumors visible clearly in the perfusion PET image with respect to the anatomy that is better delineated in the CT image. The algorithm generates an elastic...
Article
We report an algorithm for automatic elastic registration of whole body computed tomography (CT) and positron emission tomography (PET) images, which would allow accurate localization of viable tumors visible clearly in the perfusion PET image with respect to the anatomy that is better delineated in the CT image. The algorithm generates an elastic...
Article
A fluorodeoxyglucose (FDG) positron emission tomographic (PET) scan performed to stage a nasopharyngeal carcinoma revealed hypometabolic regions in multiple thoracic vertebrae. These corresponded to multiple hemangiomas seen on magnetic resonance images (MRI). The FDG findings are similar to the reduced uptake typically seen with bone scintigraphy...
Article
Radiotracer mistakenly injected into the arterial system rather than the venous system will cause image artifacts. Most commonly, a "glove phenomenon" appearance, previously described in bone scintigraphy, is noted. The authors observed this finding in the right forearm of a patient after intra-arterial fluorodeoxyglucose injection into the right a...
Article
Increased uptake in the maxilla and mandible on bone scanning is not unusual and is most commonly attributed to periodontal disease. However, sometimes atypical findings suggest other diagnoses. A 22-year-old woman with Gardner's syndrome had a bone scan to investigate a soft tissue mass in the shoulder. Intense uptake in the maxilla and mandibles...
Article
Sternocostoclavicular hyperostosis (SCCH) is a condition characterized by pain and swelling in the upper anterior chest wall. It is a chronic aseptic destructive sternocostoclavicular arthritis with nonspecific laboratory findings. On radiographic examination, hyperostotic changes of the sternoclavicular region can be seen. Bone scintigraphy is sen...
Article
Full-text available
Objective: A 66-y-old man was diagnosed with esophageal carcinoma and underwent a right thoracotomy and esophagectomy. Postoperatively, a recurring right pleural effusion developed. Because an attempt at lymphangiography failed, lymphoscintigraphy was suggested. Because of the inability to obtain radiolabeled albumin, dextran, or nanocolloid, we u...
Article
A 73-y-old patient who had thyroid carcinoma had a post-treatment, whole-body 131I scan. The scan demonstrated an artifact caused by a bracelet contaminated with radioactive perspiration. This finding resulted in an artifact on the scan and had potential radiation safety implications.
Article
A 47-year-old man with chronic renal failure underwent renal transplantation. He remained anuric and was diagnosed with an intraperitoneal urine leak by Tc-99m MAG3 renal scintigraphy. The diagnosis was confirmed by imaging fluid withdrawn via the peritoneal dialysis catheter.

Citations

... Further research is needed to address some limitations of the current study. Affine linear transforms could be improved upon using quaternion methods [39] for registration, as affine based registration tends to experience 'gimble lock'. Registration could also be improved upon by implementing an iterative image matching algorithm to increase reproducibility. ...
... Fusing both datasets can enable a synergistic metabolic and morphological evaluation, which extends beyond what each imaging technique can offer as a stand-alone technology. New elastic algorithms are able to register PET with CT or MR images from separate scanners fast and with an accuracy that is similar to manual elastic registration performed by human experts using up to 32 anatomic landmarks [63]. Current ongoing studies evaluate the utility of regional 123 I-mIBG abnormalities to guide ablation in patients with preexisting cardiomyopathy and ventricular arrhythmias. ...
... According to this, several gamma-emitted molecules have been tested as possible radiotracer for SPECT analysis [26]. Our recent investigations highlighted the fundamental role of [ 99 Tc]Sestamibi, in the detection of breast cancer lesions with high propensity to form bone metastasis [12,13]. ...
... Stomach evaluation with 18 F-FDG PET/CT may be challenging due to the risk of having heterogeneous gastric uptake distribution owing to different inflammatory and physiologic states. Besides, diabetic patients, especially in therapy with oral hypoglycemic drugs, may present an increased tracer uptake in the bowel, which affects and limits the evaluation of the scan in the gastrointestinal tract [6,7]. ...
... Urinoma usually requires invasive treatment by either interventional radiology or early surgery. [6][7][8][9] Hematomas/abscesses occur in the early postoperative period. Abscesses arise as a complication of surgery or pyelonephritis or secondary infection of urinoma, hematoma, or lymphocele. ...
... The etiologies of the false-positive findings have been reviewed and well documented (2). In most cases, false-positive radioiodine distribution is attributed to contaminated personal items or, as illustrated by the following case study, physiologic variants such as accumulation from perspiration and other bodily secretions (3)(4)(5)(6)(7)(8)(9). Medical practitioners should be mindful of the etiologies of these false-positive findings and take appropriate steps to properly identify and exclude them when they are suspected. ...
... Use of 99mTc-labeled lymphoscintigraphy coupled with CT helps in diagnosis and in anatomic localization of lymph leak. [9] Thus, we recommend the use of lymphoscintigraphy to detect the exact location of lymphorrhea, and this can also guide embolization in refractory cases. [5] Due to their role of transporting lipids and proteins to the systemic circulation, lymphatics play a crucial part in fluid homeostasis and preventing malnutrition. ...
... The increased scintigraphic activity corresponds to the radiographic changes caused by the hyperostosis. The bullhead sign is a characteristic scintigraphic pattern in demonstrating SCCH [7][8][9]. H stands for højre (Danish) = right side of the patient. The possibilities of diagnostic imaging are wide. ...
... 23 Bone scintigraphy demonstrated the presence of orbital, maxillary, and mandibular hot spots, indicating an active status of the bony lesions. 24,25 These findings suggested that the characteristics of the jaw lesions were probably gradually changing-even in late adulthood. ...
... As previously mentioned, extravenous administration could not be a cause, since the site of injection was the right arm. For the Review same reason, contamination or intra-arterial injection, which was reported to be another possible cause of soft tissue uptake [14], was excluded. The preparation of the radiopharmaceutical had no issues as well. ...