Birgit Kleim's research while affiliated with University of Zurich and other places
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Publications (58)
Positive autobiographical memories (AMs) have the potential to repair low mood, but previously depressed individuals have difficulty leveraging their positive AMs for emotion- regulation purposes. We examined whether previously depressed individuals benefit from guided, deliberate recollection of preselected AMs to counteract low mood in their dail...
In posttraumatic stress disorder (PTSD), re‐experiencing of the trauma is a hallmark symptom proposed to emerge from a de‐contextualised trauma memory. Cognitive therapy for PTSD (CT‐PTSD) addresses this de‐contextualisation through different strategies. At the brain level, recent research suggests that the dynamics of specific large‐scale brain ne...
Background
Exposure to childhood adversities (CHAD) has been found to be strongly associated with individuals' mental health and social development. Recently, it has been suggested that certain CHAD patterns exist in the population, which are more closely related to individuals' later mental health than the simple summation of adversities. The curr...
Introduction: A growing number of psychological interventions are delivered via smartphone with the aim to increase the efficacy and effectiveness of these treatments and provide scalable access to interventions for improving mental health. Most of the scientifically tested apps are based on cognitive behavioural therapy principles which are consid...
Background
A growing number of psychological interventions are delivered via smartphones with the aim of increasing the efficacy and effectiveness of these treatments and providing scalable access to interventions for improving mental health. Most of the scientifically tested apps are based on cognitive behavioral therapy (CBT) principles, which ar...
Background
The current Corona pandemic is not only a threat to physical health. First data from China and Europe indicate that symptoms of anxiety and depression and perceptions of stress rise significantly as a consequence of the pandemic. There are also anecdotal reports of increased domestic violence, divorce, and suicide rates. Hence, the Coron...
Predictive processing has become a popular framework in neuroscience and computational psychiatry, where it has provided a new understanding of various mental disorders. Here, we apply the predictive processing account to post-traumatic stress disorder (PTSD). We argue that the experience of a traumatic event in Bayesian terms can be understood as...
Predictive processing has become a popular framework in neuroscience and computational psychiatry, where it has provided a new understanding of various mental disorders. Here, we apply the predictive processing account to post-traumatic stress disorder (PTSD). We argue that the experience of a traumatic event in Bayesian terms can be understood as...
How the brain performs higher cognitive functions such as learning and memory is traditionally studied by investigating how neurons work. However, over the past two decades, evidence has accumulated which suggests that components of the extracellular matrix contribute to the storing of information through learning processes. Thus, matrix regulation...
Improved understanding of the neurobiological correlates of resilience would be an important step toward recognizing individuals at risk of developing post-traumatic stress disorder (PTSD) or other trauma-related diseases, enabling both preventative measures and individually tailored therapeutic approaches. Studies on vulnerability factors allow dr...
Background:
Resilience is a complex construct commonly defined as a dynamic process of maintenance or rapid restoration of mental health during and following exposure to stress and trauma. Resilient individuals show no or only minimal disruption in their overall functioning following trauma. Predictors of individual resilience are currently unclea...
Epidemiological data on the chronicity of posttraumatic stress disorder (PTSD) symptoms in relation to trauma type and underlying pathways are rare. The current study explored how PTSD symptoms change over time across different trauma types and examined mediators of their persistence. A trauma-exposed community sample, whereof approximately one qua...
p>Consistent failure over the past few decades to reduce the high prevalence of stress-related disorders has motivated a search for alternative research strategies. Resilience refers to the phenomenon of many people maintaining mental health despite exposure to psychological or physical adversity. Instead of aiming to understand the pathophysiology...
To accelerate recovery after traumatic events and prevent posttraumatic stress disorder (PTSD), it is critical to understand the dynamic interplay of acute stress symptoms and how they develop over time into chronic PTSD. Bryant et al¹ examined relationships among PTSD symptoms during the acute posttrauma period using network analyses. They conclud...
Background and objectives: Post-traumatic stress disorder (PTSD) is accompanied by altered autobiographical memories (AM) of the traumatic incident itself as well as of non-trauma-related events. Several studies have shown that trauma-exposed individuals developing PTSD have a reduced capacity to access specific past events that are not related to...
Study objective:
To investigate sleep's effect in the immediate aftermath of experiencing an analog trauma in the laboratory on reducing intrusive emotional memory formation.
Methods:
Sixty-five healthy women were exposed to an experimental laboratory trauma. They viewed a neutral and a trauma film in the laboratory and were randomly allocated t...
Childhood traumatic events may lead to long-lasting psychological effects and contribute to the development of complex posttraumatic sequelae. These might be captured by the diagnostic concept of complex posttraumatic stress disorder (CPTSD), as an alternative to 'classic' posttraumatic stress disorder (PTSD). CPTSD comprises a further set of sympt...
There is extensive evidence for an association between an attentional bias towards emotionally negative stimuli and vulnerability to stress-related psychopathology. Less is known about whether selective attention towards emotionally positive stimuli relates to mental health and stress resilience. The current study used a modified Dot Probe task to...
Traumatic stress can have severe consequences for both mental and physical health. Furthermore, both psychological and biological traces of trauma increase as a function of accumulating traumatic experiences. Neurobiological research may aid in limiting the impact of traumatic stress, by leading to advances in preventive and treatment interventions...
Kalisch and colleagues identify several routes to a better understanding of mechanisms underlying resilience and highlight the need to integrate findings from neuroscience and animal learning. We argue that appreciating methodological complexity and integrating neurobiological perspectives will advance the science of resilience and ultimately help...
Background
Emergency Department personnel regularly face highly stressful situations or critical incidents (CIs) that may subsequently be recalled as unbidden intrusive memories. In their most extreme form, such memories are reexperienced as if they were happening again in the present, as flashbacks. This study examined (1) which CIs are associated...
Recent meta-analyses have found that mindfulness practice may reduce anxiety and depression in clinical populations and there is growing evidence that mindfulness may also improve well-being and quality of care in health professionals. This study examined whether mindfulness protects against the impact of work-related stress on mental health and bu...
Cognitive theories of emotion posit that affective responses may be shaped by how individuals interpret emotion-eliciting situations. This study tested whether individual differences in interpretation bias (i.e., interpreting ambiguous scenarios in a more negative or positive manner) independently predict trait resilience and depression in medical...
Posttraumatic stress disorder (PTSD), one of the most common disorders following trauma, has been associated with a tendency to remember past personal memories in a nonspecific, overgeneral way. The present study investigated whether such a bias also applies to projections of future personal events. Trauma survivors (N = 50) generated brief descrip...
Facing frequent stigma and discrimination, many people with mental illness have to choose between secrecy and disclosure in different settings. Coming Out Proud (COP), a 3-week peer-led group intervention, offers support in this domain in order to reduce stigma's negative impact.
To examine COP's efficacy to reduce negative stigma-related outcomes...
Befunde aus empirischen Studien der letzten Jahre belegen die negativen Konsequenzen und Belastungen bei Studierenden im Kontext ihres akademischen Alltags. Gleichzeitig liegen Forschungsergebnisse aus dem Bereich der Schematherapie vor, welche vorwiegend praxisnahen, psychopathologischen und klinisch-therapeutischen Fragen dienen und deren zugrund...
Intrusive memories are common following traumatic events and among the hallmark symptoms of posttraumatic stress disorder (PTSD). Most studies assess summarized accounts of intrusions retrospectively. We used an ecological momentary approach and index intrusive memories in trauma survivors with and without PTSD using electronic diaries. Forty-six t...
Traumatic experiences may dramatically influence later behavior and cognitive processing. This study investigated how trauma shapes the way that we remember personal experiences. Specifically, we investigated overgeneral autobiographical memory, which is the tendency to remember autobiographical events in an overgeneral rather than specific way. We...
Sleep benefits memory consolidation. Here, we tested the beneficial effect of sleep on memory consolidation following exposure psychotherapy of phobic anxiety. Method A total of 40 individuals afflicted with spider phobia according to DSM-IV underwent a one-session virtual reality exposure treatment and either slept for 90 min or stayed awake after...
Objective:
There is a growing body of evidence for the effectiveness of trauma-focused cognitive behavior therapy (TF-CBT) for posttraumatic stress disorder (PTSD), but few studies to date have investigated the mechanisms by which TF-CBT leads to therapeutic change. Models of PTSD suggest that a core treatment mechanism is the change in dysfunctio...
Depressed individuals tend to assign internal, stable, and global causes to negative events. The present study investigated the specificity of this effect to depression and compared depressive attributional styles of individuals with major depression (MD), post-traumatic stress disorder (PTSD), and healthy controls. We indexed attributional style u...
To identify reasons for ordering computed tomography pulmonary angiography (CTPA), to identify the frequency of reasons for CTPA reflecting defensive behavior and evidence-based behavior, and to identify the impact of defensive medicine and of training about diagnosing pulmonary embolism (PE) on positive results of CTPA.
Physicians in the emergency...
The chapter reviews the contribution of information processing models to understanding the development and maintenance of posttraumatic stress disorder. Individual differences in cognitive processing during the trauma and basic memory mechanism, such as priming and associative learning, may help explain why people with PTSD involuntarily re-experie...
Depression and posttraumatic stress disorder (PTSD) are common after trauma, but it remains unclear what factors determine which disorder a trauma survivor will develop. A prospective longitudinal study of 222 assault survivors assessed candidate predictors derived from cognitive models of depression and PTSD at 2 weeks posttrauma (N = 222), and de...
Minor brain injury is a frequent condition. Validated clinical decision rules can help in deciding whether a computed tomogram (CT) of the head is required. We hypothesized that institutional guidelines are not frequently used, and that psychological factors are a common reason for ordering an unnecessary CT.
Physicians at the emergency department...
The objective of this study was to examine the psychometric properties of the Autobiographical Memory Test (AMT), which is widely used to measure overgeneral autobiographical memory in individuals with depression and a trauma history. Its factor structure and internal consistency have not been explored in a clinical sample. This study examined the...
The present article describes the prevalence and predictors of adverse mental health reactions in first responders, a population exposed to stress (rather than a population who are exposed). Mental health impairments in first responders exact considerable personal and public costs and are likely to negatively affect work performance, including prov...
Analysis of changes in the behaviour of wearing protective equipment by alpine skiers and snowboarders after injury, performed at a level I trauma centre in Switzerland.
We present a study, using a standardised questionnaire, assessing behaviour on ski slopes by adult patients admitted between Oct 2007 and April 2008. Patients were re-interviewed a...
A depressogenic attributional style, i.e., internal, stable and global causal interpretations of negative events, is a stable vulnerability factor for depression. Current measures of pessimistic attributional style can be time-consuming to complete, and some are designed for specific use with student populations. We developed and validated a new sh...
Despite the fact that medication adherence is among the most important health related behaviors in relapse prevention and recovery in schizophrenia, it is often not sufficiently endorsed by patients. Poor insight and negative attitudes towards medication are risk factors for non-adherence. Their relationship and the influence of more general attitu...
Intrusive re-experiencing in post-traumatic stress disorder (PTSD) comprises distressing sensory impressions from the trauma that seem to occur 'out of the blue'. A key question is how intrusions are triggered. One possibility is that PTSD is characterized by a processing advantage for stimuli that resemble those that accompanied the trauma, which...
Research into cognitive mechanisms in posttraumatic stress disorder (PTSD) typically comprises two types of studies. The first group of studies is conducted with survivors of traumatic events and assesses the association between PTSD and cognitive variables with questionnaires and/or information processing paradigms. In the second group of studies,...
To investigate in trauma survivors the predictive validity of heightened physiological responsivity to script-driven imagery for the development of posttraumatic stress disorder (PTSD) and to evaluate the interactive effect of survivors' sex. Physiological responses to idiosyncratic trauma reminders may be predictive of later PTSD. The majority of...
Clinical psychology is concerned with the diagnosis and treatment of mental disorder, such as anxiety or depression (e.g., Davison & Neale, 2000). Despite some cross-cultural differences in the exact prevalence of psychological disorders, most disorders are common across the world, to all cultures and ethnic groups (e.g., Kleinman, 2004; Merikangas...
Background: The stigma of mental illness has been shown to be a barrier to recovery in schizophrenia. Aims: The present study aimed to examine the influence of perceived stigma on self-efficacy and the coping styles of secrecy and withdrawal over and above selected sociodemographic and clinical variables and psychopathology. Method: Outpatients dia...
Two studies of assault survivors (Ns = 180, 70) examined associations between posttraumatic growth (PTG) and posttrauma psychopathology. Both studies found significant curvilinear associations between PTG and posttraumatic stress disorder, whereas only Study 1 found a curvilinear association between PTG and depression symptom severity. Survivors wi...
In this prospective longitudinal study, the authors examined the relationship between reduced specificity in autobiographical memory retrieval and the development of depression, posttraumatic stress disorder (PTSD), and specific phobia after injury in an assault. Assault survivors (N = 203) completed the Autobiographical Memory Test (J. M. G. Willi...
This study tested the hypothesis that trauma memories are disjointed from other autobiographical material in posttraumatic stress disorder (PTSD). Assault survivors with (n = 25) and without PTSD (n = 49) completed an autobiographical memory retrieval task during script-driven imagery of (a) the assault and (b) an unrelated negative event. When lis...
Several symptom screening instruments have been developed to identify trauma survivors at risk for chronic posttraumatic stress disorder, but few of these have been thoroughly evaluated to date. In this study, a range of symptom combination scoring rules derived from the literature were applied to the Posttraumatic Diagnostic Scale and evaluated in...
The concept of internalized stigma or self-stigma is central to the understanding of the psychological harm caused by stigma. In this study, we aim to demonstrate how the evaluative dimension of self-concept (self-efficacy and empowerment) mediates the psychological effects of self-stigmatizing and coping with stigma. As important examples of psych...
Citations
... These dynamic patterns of specific brain connectivity known as spatiotemporal measures have already been shown to be associated with thought processing, and specific cognitive and affective states [27,[30][31][32][33]. Moreover, alterations of brain dynamics patterns have been associated with post-traumatic stress disorder, schizophrenia, and Alzheimer's disease [34][35][36]. ...
... Considering the possible explanation, the resulting insecure attachment to parents may reduce the emotional security in children, probably making them more easy to worry that something negative will happen to them, while without the ability to control it [50]. Additionally, the previous study has shown that being raised by con ictive or abusive parents was strongly associated with various mental disorders, especially internalizing anxiety disorders [51], which was in line with the evidence showing domestic violence and childhood abuse as the two most important risk factors for anxiety disorders [52], further supporting that certain co-occurrence of ACEs were critical for speci c mental problems [53]. ...
... Two special issues appeared in 2019, the first on adjustment to chronic illness (see Figueiras & Neto, 2019) and the second on human rights and psychology (see Söderström et al., 2019). Others that have appeared this year or are in the pipeline include: understanding, predicting and preventing violence (issue 2, edited by Carlo Garofalo and Rannveig Sigurvinsdóttir, see Garofalo & Sigurvinsdóttir, 2020), the psychology of aging (issue 3, edited by Frieder Lang, Matthias Kliegl, and Isabelle Albert; see Lang et al., 2020), early responses to trauma (edited by Birgit Kleim, see Kleim, 2020) political extremist identification (edited by Catarina Kinnvall, in progress), climate change (Tony Wainwright and Katariina Salmela-Aro, in progress), creativity (Todd Lubart, in progress), and now also of course psychology and the COVID-19 pandemic (Berndt Roehrle and Nicola Gale, in progress). ...
... This behavioral intervention consists of personalized "push" notifications that are provided in the form of tips or life insight messages via the app. Tips, consistent with cognitive behavioral theory [28,29], are nondata-based statements that are motivational-focused (why change) or ability-focused (how to change) to promote healthy behaviors. Life insights, targeting enhanced self-monitoring and self-management as a tool of behavior change, include push notifications that summarize personalized data. ...
... In den Feldern Psychologie, Pädagogik und Psychotherapie ist ‚Resilienz' in den letzten Jahren zu einem absoluten Modebegriff geworden. Und spätestens mit der Corona-Krise wird der Begriff in Diskursen zum Umgang mit der Pandemie, sei es mit psychologischem (Veer et al. 2020) oder politischem Fokus (Reckwitz 2020), stark strapaziert. Der Begriff wird dabei durchgehend in einer affirmativen Art und Weise gebraucht. ...
... One way to conceptualize the impact of environmental risk factors and related psychopathological conditions in terms of pp is the way our internal models shape with exposure to environmental factors. In other words, environmental risk factors, such as trauma, chronic stress, or adverse childhood experiences, can shape our internal models and lead to maladaptive predictions and perceptual biases [173][174][175]. For instance, Wilkinson et al., 2017 try to explain the effects of various psychological trauma (e.g., type 1 vs. type 2 trauma) on the human nervous system with the PP framework [175]. ...
... Therefore, proline is stored in the ECM as collagen, which can serve both as a reservoir and dump for proline (Phang et al., 2010). Of note, components of the ECM such as matrix metalloproteinases, which degrade collagen and release proline, and perineuronal nets have been recently suggested as new key players in the development of psychiatric disorders (Bach et al., 2019). Strikingly, microbiota transfer from humans to mice highlighted a strong upregulation of pathways associated with the ECM and collagen homeostasis as well as GABA-and proline-dependent neurotransmission in the mPFC of mice that received microbiota from human donors with high depression scores. ...
... Existing systematic reviews on neurobiological mechanisms of resilience focus on adult populations, or pool findings across age groups (Bolsinger et al., 2018;Galatzer-Levy et al., 2018;Moreno-López et al., 2020;Roeckner et al., 2021). Given that childhood and adolescence are periods of dynamic brain development, it is important to examine them separately from adults as neurobiological resilience mechanisms could differ (Fuhrmann et al., 2015). ...
... For this reason, the finding should be interpreted with caution. Taken together, all demographic and job-related predictors only seem to account only for a small amount of variance in resilience levels as measured by the RS-5 in HCW, a fact that has already been noted by other authors [57]. ...
... Intratraumatic factors, defined as trauma-related factors, include the severity of trauma and subsequent dissociation symptoms. [11][12][13][14] With regard to posttraumatic factors, comorbid depressive symptoms, anxiety symptoms, and feelings of shame after trauma have been studied, and all these factors were known to be associated with chronic PTSD. Particularly, the relations between the chronicity of PTSD and social reactions to survivors after trauma, from positive support to negative stigmatization, have been examined. ...