Bhoomika Ahuja's scientific contributions
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Publications (4)
This initial report presents a neonatal rat model with exposure to a transient intermittent hypoxia (IH), which results in a persisting diabetes-like condition in the young rats. Twenty five male pups were treated at postnatal day 1 with IH exposure by alternating the level of oxygen between 10.3% and 20.8% for 5h. The treated animals were then mai...
Perinatal hypoxia commonly causes brain injury in infants, but the time course and mechanisms underlying the preferential male injury are unclear. Intermittent hypoxia disturbs cerebellar γ-aminobutyric (GABA)-A receptor profiles during the perinatal period, possibly responding to transient excitatory processes associated with GABA(A) receptors. We...
Approximately 70% of obstructive sleep apnea (OSA) patients are afflicted with Type-2 diabetes; both diseases may develop from common injury in early life. Rodents treated with short-term IH, which mimics sleep apnea, show decreased insulin sensitivity. The diabetes/IH relationship may have its origins in perinatal life, with a high incidence of ap...
Orexinergic signals for saliva secretion initiate from the lateral hypothalamus (LH), a principal site for regulation of feeding, drinking and energy homeostasis. A set of these hypothalamic neurons project to the superior salivatory nucleus (SSN), from where efferent parasympathetic cholinergic motor signals feed into the parenchyma of the submand...
Citations
... Co-occurrence of acute respiratory distress and diabetes can be life-threatening. Brief repetitive hypoxic exposure to rats reduces insulin secretion and elevates fasting blood glucose levels; these sequelae continue for as long as 12 months [1]. Acute post-infection disruption of glycometabolic control commonly accompanies severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection [2,3]. ...
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... The level of this latter group is an indicator of tissue damage [19]. Other findings proposed partial protection for the female rats versus stress insult in the cerebellum and down-regulation of γ-aminobutyric (GABA) receptors [20]. This study was conducted to elucidate to what extent therapeutic doses of lithium carbonate affect the amino acid interconversion and the integrity responsible protein fraction, through different treatment periods at rat brain tissue level. ...
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