Bhanu K Bhakhri’s research while affiliated with All India Institute of Medical Sciences and other places

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Publications (1)


Parameters of metabolic syndrome in Indian children with epilepsy on valproate or phenytoin monotherapy
  • Article
  • Full-text available

July 2015

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156 Reads

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11 Citations

Journal of Pediatric Neurosciences

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Objectives: The prevalence of obesity is rapidly increasing among Indian children, who, in general, are more prone to develop metabolic complications at an early age. Valproate and phenytoin are commonly used antiepileptic drugs in children. This study aimed to assess the parameters of the metabolic syndrome in Indian children with epilepsy on valproate or phenytoin monotherapy. Methods: This cross-sectional study recruited children from the Pediatric Epilepsy Clinic, Department of Pediatrics, Kalawati Saran Children Hospital, New Delhi from March 2012 to September 2012. All consecutive children diagnosed with epilepsy as per International League Against Epilepsy definition aged 3-18 years on valproate or phenytoin monotherapy for at least 6 months were enrolled at a tertiary care children's hospital in Northern India. After clinical and anthropometric evaluation (including body mass index [BMI] and waist circumference), the blood samples were analyzed for fasting serum glucose, total cholesterol, high-density lipoprotein-cholesterol, and serum triglyceride. Results: Children with BMI >95(th) centile and waist circumference >90(th) centile were not significantly different among children on valproate and phenytoin monotherapy. Children on valproate had significantly higher mean serum triglyceride (96.9 mg/dL vs. 77.6 mg/dL; P < 0.001) and total cholesterol (148.3 mg/dL vs. 132.8 mg/dL; P = 0.002) levels as compared to children on phenytoin monotherapy. Conclusions: The lipid abnormalities may be observed in children on valproate or phenytoin therapy and may warrant periodic screening.

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Citations (1)


... [44] VPA-treated patients were also found to have higher concentrations of triglycerides, serum cholesterol, uric acid, and lower levels of high-density lipoprotein cholesterol in a few studies. [42,45,46] While VPA-related metabolic disturbances leading to nonalcoholic fatty liver disease have also been reported in certain studies. [47,48] Valproic acid and endocrine dysfunction VPA also affects the metabolism of other hormones. ...

Reference:

Obesity and Metabolic Syndrome in Patients with Epilepsy, their Relation with Epilepsy Control
Parameters of metabolic syndrome in Indian children with epilepsy on valproate or phenytoin monotherapy

Journal of Pediatric Neurosciences