Benzhong Zhang's research while affiliated with Lanzhou University and other places

Publications (7)

Article
Indoor air pollution (IAP) is one of the leading risk factors for various adverse health outcomes including premature deaths globally. Even though research related to IAP has been carried out, bibliometric studies with particular emphasis on this topic have been lacking. Here, we investigated IAP research from 1990 to 2019 retrieved from the Web of...
Article
Growing evidence indicates that nickle and its compounds have adverse effects on the cardiovascular system. In this study, the cytotoxic insults caused by nickel sulfate (NiSO4) in human umbilical vein endothelial cells (HUVECs) were explored by examining cell viability, oxidative stress, inflammation, apoptosis, and MAPK signaling pathway activity...
Article
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Acute exacerbation of chronic obstruction pulmonary disease (AECOPD) as a respiratory disease, is considered to be related to air pollution by more and more studies. However, the evidence on how air pollution affect the incidence of AECOPD and whether there are population differences is still insufficient. Therefore, we select PM10, PM2.5, SO2, NO2...
Article
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Background: Hypertension is the leading risk factor for cardiovascular disease (CVD), however, the studies on lifestyle and genetic risks in Chinese pilgrims to Hajj was limited. The aim of this study is to examine the prevalence and associated lifestyle and genetic risks for hypertension among Hui Hajj pilgrims in China. Methods: We performed a...
Article
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Latent Mycobacterium tuberculosis (Mtb) infection (LTBI) is the main clinical manifestation after Mtb exposure. During the latent phase, Mtb retards the attempts of eradication by the host immune system. The dormancy survival regulator (DosR) is held as essential for Mtb persistence. Rv1737c is predominantly expressed by the Mtb in latent infection...
Article
There is an urgent need to identify the potential risk factors for activating latent Mycobacterium tuberculosis infection. In this study, we evaluated the immune function of Rv1737c, which is a latency‐associated antigen of dormancy survival regulator (DosR) of M. tuberculosis in a mouse model. Our data showed that mice pretreated with recombinant...
Article
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The aim of this study is to identify the role of Tet1-mediated DNA demethylation in the neurotoxicity caused by unconjugated bilirubin (UCB) in vitro. Primary neuronal cells after cultured for 72 h were exposed to UCB (0-100 μmol/L) for 24 h. Following exposure to UCB cytotoxicity was determined with the methyl tetrazolium (MTT) assay, reactive oxy...

Citations

... The MAPK family is composed of p38 MAPK cascades, c-Jun NH2-terminal kinases (JNK) and ERK, which are closely related to neurodegenerative diseases [115]. The function of JNK is similar to that of p38, which is related to inflammation, apoptosis and growth [116,117]. ERK mainly controls cell growth and differentiation. Oxidative stress induced by ROS was found to activate both p38 and JNK, and the level of phosphorylation increased [118]. ...
... The 2020 Report on the State of Ecology and Environment in China issued by Ministry of Ecology and Environment showed that 43.3% of 337 cities exceeded the ambient air quality standard (2020). As people pay more attention to environmental pollution, some studies on the association between COPD and air pollution have been conducted in China (Feng et al. 2019;Jin et al. 2022;Lin et al. 2020;Liu et al. 2022;Qiu et al. 2018;Zhang et al. 2020;Zhang et al. 2018). However, these studies found different components of air pollutants affecting COPD admissions, with inconsistent conclusions and lack of research analysis in recent years. ...
... Similarly, South African pilgrims had a mean age of 49.2 years, and 49.4% were aged 50 years or older. While some studies on pilgrims from specific countries reported higher mean age for pilgrims (57-66 years) [8,23,24], our results are in accordance with data on the overall Hajj population where over 50% are aged 50 years or older [20]. Yet, it appears that the proportion of South African pilgrims aged 50 years or older had increased over the years from 34.5% in 2006 to 40% in 2007 to 49.4% in the current study [25]. ...
... Various studies have shown that several Mtb antigens recognised by TLR2 induce the activation of MAPK and subsequently NF-κB translocation to trigger the production of proinflammatory cytokines (Table 1). However, a few Mtb ligands have (Su et al., 2019(Su et al., , 2016Pennini et al., 2006;Sánchez et al., 2012;Pecora et al., 2006;Padhi et al., 2019;Aguilar-López et al., 2019;Drage et al., 2010;Gehring et al., 2004;Shukla et al., 2014;Chen et al., 2012;Wang et al., 2017;Elass et al., 2005;Gilleron et al., 2006;Puissegur et al., 2007;Quesniaux et al., 2004;Tapping and Tobias, 2003;Bansal et al., 2010;Chaturvedi et al., 2010;Bansal et al., 2010;Chen et al., 2013;Aguilar-López et al., 2019;Basu et al., 2007;Palucci et al., 2016;Huang et al., 2010;Long et al., 2019a;Thi et al., 2013;Abraham et al., 2016;Bhat et al., 2012a;Bhat et al., 2012b;Nair et al., 2011Nair et al., , 2009Su et al., 2015;Deng et al., 2016Deng et al., , 2014Xu et al., 2015;Gong et al., 2019;Su et al., 2018;Danelishvili et al., 2016;Tiwari et al., 2014;Gao et al., 2019;Gao and Sampson, 2014;Klink et al., 2013;Byun et al., 2012;Gu et al., 2016;Kumar et al., 2017;Liu et al., 2016;He et al., 2015;Yihao et al., 2015;Kwon et al., 2017;Peddireddy et al., 2016;Kim et al., 2016;Kumar et al., 2013;Saraav et al., 2017;Pattanaik et al., 2021;Lee et al., 2009;Madan-Lala et al., 2014Rengarajan et al., 2008;Choi et al., 2019;Kim et al., 2017;Grover et al., 2018;Tiwari et al., 2015;Choi et al., 2016;Kim et al., 2012;Lee et al., 2014;Park et al., 2021;Choi et al., 2018;Sharma et al., 2016;Kim et al., 2013;Choi et al., 2015;Kim et al., 2018;Bulut et al., 2005;Shariq et al., 2021;Lee et al., 2021;Lee et al., 2020;Sharma et al., 2021;Dong et al., 2016a;Jang et al., 2019Jang et al., , 2018Kumar et al., 2012;Lin et al., 2019;Samten et al., 2009;Jung et al., 2006;Lim et al., 2015;Sanchez et al., 2009;Khan et al., 2008;Parveen et al., 2013;Bulut et al., 2005;Park et al., 2019;Bandyopadhyay et al., 2017. (continued on next page) K.P. Pattanaik et al. ...
... The human body mainly relies on cellular immunity to fight against TB, and macrophages are important immune cells involved in Mtb infection [34]. Studies demonstrated that macrophage polarization was involved in the occurrence and development of TB [35]. Wang et al. reported that two types of macrophage polarization (M1 and M2) were present in the tissues and peripheral blood of patients with STB, indicating that macrophages play proinflammatory and anti-inflammatory roles [36]. ...
... The present study also showed that UCB may serve as a ROS generator to increase ROS formation. Several reports have demonstrated that UCB may increase ROS formation [48][49][50][51] or reduce ROS levels [48,51,52], which are dependent on UCB levels or cell status (/or targeted tissues or cell types). For example, heart endothelial (H5V), kidney tubular (HK2), and neuronal (SH-SY5Y) cell lines and high concentrations of UCB (>3.6 µM in SH-SY5Y cells, >15 µM in H5V cell, and >15 µM in HK2 cells) significantly increased intracellular ROS production, but this phenomenon was not observed in HepG2. ...