Bei Liu’s research while affiliated with Wuhan University and other places

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Publications (8)


FIGURE 2 
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Rapid Risk Assessment Report for Schistosomiasis Epidemic in Jianli County Caused by the Sunk "Oriental Star" Cruise Ship
  • Article
  • Full-text available

September 2017

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157 Reads

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3 Citations

Disaster Medicine and Public Health Preparedness

Ziling Ni

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Xiaodong Tan

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Bei Liu

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[...]

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Background: At 9:28 pm on June 1, 2015, the cruise ship "Oriental Star" sank into Yangtze River in Jianli County, with 422 people killed. When the accident occurred, the Chinese government took immediate action and dispatched more than 9000 rescuers. The risk for outbreak of schistosomiasis was increased because of the shipwreck. Obviously it is critical to carry out risk assessment as soon as possible. Methods: By means of the Delphi method, the situation was analyzed so that the government could fathom the severity of the accident. Then, through matrix and sigma-plotting (3-dimensional graphics) methods, related authorities performed risk assessment after site investigation. Results: The latest news reported that more than 9000 people were involved in the rescue. The affected river was analyzed and mapped using SigmaPlot software, according to which the possibility, harmfulness, and controllability of the accident were determined to be medium (6), medium (6), and poor (7), respectively. Conclusion: The site of the accident where the cruise ship sank and rescue operations were carried out is a schistosomiasis epidemic area with high mortality and morbidity. The chance of an outbreak of the schistosomiasis epidemic in Jianli County is quite high. To protect people in this county from the epidemic, relevant logistic services should be arranged and all remains should be cleared up carefully. (Disaster Med Public Health Preparedness. 2017;page 1 of 7).

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Figure 2. The dose-response relationship of BMI and VI. Adjusted for age, sex, level, district, hierarchy, scores, starting reading age, monthly family income, homework in recess, hours of daily outdoor activities, time of daily homework, weekend tutoring, daily sleep hours, control of TV and computer use. 
Table 2 . The association between BMI and Visual Impairment (VI) in the whole population. 
Table 3 . The association between BMI and VI stratified by hierarchy. 
Table 3 . The association between BMI and VI stratified by hierarchy. 
Associations between Body Mass Index and Visual Impairment of School Students in Central China

October 2016

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556 Reads

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29 Citations

Body Mass Index (BMI) is a risk indicator for some eye diseases. However, the association between BMI and Visual Impairment (VI) was not quite certain in Chinese students. Our aim was to assess the relationship between BMI and VI with a cross-sectional study. A total of 3771 students aged 6-21 years, including 729 with VI, were sampled from 24 schools in Huangpi District of central China to participate in the study. A multistage stratified cluster random sampling was adopted. Each of the students answered a questionnaire and had physical and eye examinations. The association between BMI and VI was examined with logistic regression and threshold effect analysis. The prevalence of VI was 19.33% (729/3771). Compared to normal and underweight, overweight/obese students showed a stronger relation with VI in age- and sex-adjusted (Odds Ratio (OR) = 16.16, 95% Confidence Interval (CI): 12.37-21.09, p < 0.001) and multivariable models (OR = 8.32, 95% CI: 6.13-11.30, p < 0.001). There was a nonlinear dose-response relation between levels of BMI and the prevalence of VI (p < 0.001). A high level of BMI (≥19.81 kg/m²) was associated with a higher VI prevalence (adjusted OR = 1.20, 95% CI: 1.15-1.25, p < 0.001). In conclusion, the study demonstrated BMI levels were significantly associated with the prevalence of VI.





Risk assessment of schistosomiasis transmission on rescue workers involved in "Oriental Star shipwreck event"

October 2015

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2 Reads

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1 Citation

Chinese Journal of Schistosomiasis Control

Objective: To assess the impact of the "Oriental Star shipwreck event" on the risk of schistosomiasis transmission in Jianli County, Hubei Province, so as to provide the evidence for formulating appropriate measures of schistosomiasis prevention and control. Methods: Based on the field observation and investigation, the data of the on-the-spot rescue and the historical endemic situation of schistosomiasis in Jianli County were collected and analyzed. Meanwhile, the focus group discussion and risk matrix were conducted to assess the risk of schistosome infection of the rescuers. Results: Over 10 000 rescuers participated in the search operation, including the armed police forces, local people, reservists and so on. The armed police forces were the major components, which accounted for 39%. Jianli country was schistosomiasis endemic area with a high infection level in history, but the endemic situation had been mitigated significantly after years of positive prevention and treatment; the schistosome infection rate of population was 0.44% in 2014 and the Oncomelania hupensis snail area was only 6.6 hm2 around the rescue areas in the upstream and downstream. In addition, the snail density was not high, and no infected snails had been found for 11 years. The risk of schistosome infection was in the medium level. Conclusions: Though there exists the schistosome infection risk in the water area where the accident happened, the probability of occurrence is not high. In order to prevent the outbreak and endemic of schistosomiasis, the protection measures and health education to the rescuers as well as snail control and monitoring, and early-warning should be strengthened.


Meta-analysis of the diagnostic efficiency of the questionnaires screening for schistosomiasis

June 2015

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96 Reads

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8 Citations

Parasitology Research

Schistosomiasis is the second widespread tropical disease that affects the health of over 240 million people of 78 countries. Questionnaires have been commonly used to diagnose schistosomiasis, while no meta-analysis of their efficacy had been reported previously. This meta-analysis was conducted to assess their diagnostic accuracy of schistosomiasis. Studies published prior to December 1, 2014, that had used questionnaires as a diagnostic tool were searched in PubMed, Medline, EMBASE, and China National Knowledge Infrastructure (CNKI) database. A total of 32 studies with 72,812 cases were identified for the meta-analysis. The best diagnostic odds ratio (DOR) was obtained from Schistosoma haematobium (67.68, 95 % confidence interval (CI) = 31.48 to 145.54), followed by Schistosoma japonicum (11.74, 95 % CI = 4.59 to 30.05) then Schistosoma mansoni (2.98, 95 % CI = 1.95 to 4.54). Pooled sensitivity and specificity were respectively 0.82, 0.88, and 0.46, and 0.59, 0.86, and 0.81 for S. japonicum, S. haematobium, and S. mansoni. The multivariable subgroup analyses showed that the questionnaires which had been pretested and standardized had better diagnostic performance. The result suggested that questionnaires can be used to diagnose schistosomiasis with moderate sensitivity and specificity and the questionnaires for diagnosing S. haematobium performed best.


Figure 3: Network of proteins. A. The network predicted with methods of neighborhood, gene fusion, co-occurrence, co-expression, experiments, databases and text-mining. This network was enriched in interaction with a p-value of 5.55E-15. B. The network predicted only with experiments. Disconnected nodes were hidden. This network was not enriched in interaction. C. KEGG pathway related to cervical cancer. Only the part related to results of this study is plotted. This graph was reorganized based on viral carcinogenesis (hsa05203) from KEGG. 
Table 3 : Seven miRNA signature correlated with prognosis
Table 4 : Mature sequences of miRNA signature and experimentally validated mRNA targets
Table 5 : Slim gene ontology enrichment
Table 6 : KEGG pathway enrichment
Seven protective miRNA signatures for prognosis of cervical cancer

November 2014

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65 Reads

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24 Citations

Oncotarget

Cervical cancer is the second cause of cancer death in females in their 20s and 30s, but there were limited studies about its prognosis. This study aims to identify miRNA related to prognosis and study their functions. TCGA data of patients with cervical cancer were used to build univariate Cox's model with single clinical parameter or miRNA expression level. Multivariate Cox's model was built using both clinical information and miRNA expression levels. At last, STRING was used to enrich gene ontology or pathway for validated targets of significant miRNAs, and visualize the interactions among them. Using univariate Cox's model with clinical parameters, we found that two clinical parameters, tobacco use and clinical stage, and seven miRNAs were highly correlated with the survival status. Only using the expression level of miRNA signatures, the model could separate patients into high-risk and lowrisk groups successfully. An optimal feature-selected model was proposed based on two clinical parameters and seven miRNAs. Functional analysis of these seven miRNAs showed they were associated to various pathways related to cancer, including MAPK, VEGF and P53 pathways. These results helped the research of identifying targets for targeted therapy which could potentially allow tailoring of treatment for cervical cancer patients.

Citations (5)


... On 1 June 2015, the ʺOriental Starʺ passenger ship was traveling on the Yangtze River in Jianli, Hubei Province, China with 454 people on board when it capsized in a severe thunderstorm, resulting in 442 deaths [23,24]. The recognition algorithm of the airflow field structures was also tested by this extreme gale case. ...

Reference:

An Automatic Recognition Method for Airflow Field Structures of Convective Systems Based on Single Doppler Radar Data
Rapid Risk Assessment Report for Schistosomiasis Epidemic in Jianli County Caused by the Sunk "Oriental Star" Cruise Ship

Disaster Medicine and Public Health Preparedness

... Wild feces were collected using a grid method, with 20 m × 20 m as a survey unit and every two survey units separated by 20 m (Chu, 2010;Zuo et al., 2016). Based on the results of the field investigation, the numeric values of all the parameters were obtained by the Delphi method, including harmfulness (A, 0-10, referring to the impact of the occurrence of acute schistosomiasis infection), the possibility of acute infection (B, 0-10, referring to the probability of the occurrence of acute schistosomiasis infection) and the level of uncontrollability (C, 0-1, referring to the possibility that the risk could not be controlled) (Huang, 2011;Ying et al., 2015). The risk value was calculated based on the formula Z = A × B (where Z is the risk value, which refers to the degree of harm to the population) (Huang, 2011). ...

Risk assessment of schistosomiasis transmission on rescue workers involved in "Oriental Star shipwreck event"
  • Citing Article
  • October 2015

Chinese Journal of Schistosomiasis Control

... 15 However, studies focusing on BMI-VI association have yielded controversial results. [17][18][19][20][21][22][23][24][25] These widely divergent conclusions not only bring doubts about whether obesity and adiposity indexes could be considered risk factors or screening tools of VI but also challenge whether BMI is applicable to hold its representative role of body adiposity index in VI-related surveys. ...

Associations between Body Mass Index and Visual Impairment of School Students in Central China

... These miRNAs affected stability of the expression of their target genes and played an essential role in the pathogenesis of endometriosis. Furthermore, several miRNAs were also categorized as proangiogenic miRNAs, playing role in the regulation of vascular endothelial growth factor A (VEGFA) (13,14) and MMP3 translations (15). In general, VEGFA mRNA is targeted by miR-93, resulting in cells proliferation inhibition (16). ...

Seven protective miRNA signatures for prognosis of cervical cancer

Oncotarget

... The fieldwork was carried out between April and October 2018. The individual questionnaire (S1 Appendix) was developed on the basis of previously used questionnaires, which were further developed to allow the assessment of demographic information, signs, symptoms and water related activities [46][47][48]. It was administered by members of the research team with the exception of the main researcher. ...

Meta-analysis of the diagnostic efficiency of the questionnaires screening for schistosomiasis

Parasitology Research