Beata Horeczy’s research while affiliated with Rzeszów University and other places

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Publications (16)


Testing the spillover effect of intimate partner violence (IPV) victimisation on emotionally abusive and harsh parenting practices: The application of propensity score matching
  • Article

May 2024

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55 Reads

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1 Citation

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Grzegorz Inglot

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Rafal Piasek

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[...]

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Prior research reported a significant association between intimate partner violence (IPV) victimisation and negative parenting, but there was an overreliance on U.S. samples and families from low socioeconomic status backgrounds. Therefore, this quasi-experimental study examined the association between recent IPV victimisation and abusive parenting practices in a sample of community-based women from Poland. Participants were mothers of children aged 2-5 years (N = 610) attending an outpatient clinic located in a city in south-eastern Poland. Mothers were asked about their IPV experiences in the past 12 months and were classed as either IPV positive or IPV negative. Outcome measures assessed emotionally abusive and harsh parenting practices. All data were collected online. To reduce bias in background characteristics (i.e., age, education, employment status, financial distress, self-esteem, childhood violence history, alcohol problems, current mental distress, social support, exposure to COVID-19 pandemic related stressors, and child sex), we applied propensity score matching (PSM) technique. Group differences before and after matching were examined using independent samples t-tests. Pre-matching analyses revealed that IPV positive mothers used significantly more emotionally abusive and harsh parenting practices than IPV negative mothers. However, the two samples differed substantially on six background characteristics which are known risk factors for IPV and child maltreatment (financial distress, self-esteem, childhood violence history, current mental distress, social support, and exposure to COVID-19 pandemic related stressors). PSM was successful in reducing those imbalances. Post-matching group comparisons were statistically non-significant for emotionally abusive and harsh parenting, disproving the spillover hypothesis. We conclude that IPV victimisation is not related to emotionally abusive and harsh parenting practices when controlling for confounding variables.


Psychological Medicine A repeated cross-sectional survey assessing university students' stress, depression, anxiety, and suicidality in the early stages of the COVID-19 pandemic in Poland

January 2024

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42 Reads

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16 Citations

Background. The time of widespread outbreaks of infectious diseases can lead to elevated stress and mental health problems among all persons affected, and in particular those subgroups of the population that are at an increased risk of mental health problems. One such vulnerable group constitutes university students. The aim of this study is to assess stress, depression, anxiety, and suicidality among different groups of university students (medical, psychology, and other). Methods. Using a repeated cross-sectional study design, we collected survey data among a large sample of 7228 university students from Poland (mean age = 22.78, S.D. = 4.40; 81% female). Data were collected in five waves, during the first 2 months of the COVID-19 pandemic in Europe (March and April 2020). Results. The results demonstrate a significant increase in depression levels as the pandemic was progressing. We also found that female students scored significantly higher than male students on depression, anxiety, and stress. Psychology students recorded the lowest scores on depression and anxiety. Young adult students (aged 18-24 years) had more symptoms of depression, anxiety, and suicidality than adult students (⩾25 years). Conclusions. These results provide insights into stress and mental health among university students during the early stages of the COVID-19 pandemic. Findings can be used for a more effective identification of students who may struggle during next stages of the pandemic and future crises.


Brain Fog Scale (BFS): Scale development and validation

September 2023

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650 Reads

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14 Citations

Personality and Individual Differences

Recently, we have witnessed a rapid increase in the number of research studies in the area of brain fog, predominantly due to the fact that it is reported to be a frequent long COVID condition. However, the construct of brain fog remains ill-defined and a common method of assessment of the condition is lacking. Therefore, the main aim of the current study was to develop and validate a self-report Brain Fog Scale (BFS) for use in clinical and research settings. Participants were 1452 (n = 996, 68.6% female) Polish university students. The data were collected anonymously through self-completion questionnaires. Results indicate that the 23-item BFS has good psychometric properties. Based on principal component analysis (PCA) and confirmatory factor analysis (CFA) results, the scale is best captured by a three-factor solution, with six items loading on the mental fatigue factor, nine items loading on the impaired cognitive acuity factor, and eight items loading on the confusion factor. We found that individuals who tested positive for COVID-19 had significantly higher mental fatigue, impaired cognitive acuity, and confusion scores than matched controls who never tested positive for COVID-19.


Figure 1. Study flow diagram. ESPB, erector spinae plane block group; CON, control group.
Figure 2. Oxycodone consumption. ESPB, erector spinae plane block group; CON, control group.
Patient demographics.
Severity of persistent postoperative pain.
Incidence of chronic postsurgical pain (CPSP).
Erector Spinae Plane Block Decreases Chronic Postoperative Pain Severity in Patients Undergoing Coronary Artery Bypass Grafting—A Prospective Cohort Study
  • Article
  • Full-text available

October 2022

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69 Reads

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14 Citations

Up to 56% of patients develop chronic postsurgical pain (CPSP) after coronary artery bypass grafting (CABG). CPSP can affect patients’ moods and decrease daily activities. The primary aim of this study was to investigate CPSP severity in patients following off-pump (OP) CABG using the Neuropathic Pain Symptom Inventory (NPSI). This was a prospective cohort study conducted in a cardiac surgery department of a teaching hospital. Patients undergoing OP-CABG were enrolled in an erector spinae plane block (ESPB) group (n = 27) or a control (CON) group (n = 24). Before the induction of general anesthesia, ESPB was performed on both sides under ultrasound guidance using 0.375% ropivacaine. The secondary outcomes included cumulative oxycodone consumption, acute pain intensity, mechanical ventilation time, hospital length of stay, and postoperative complications. CPSP intensity was lower in the ESPB group than in the CON group 1, 3, and 6 months post-surgery (p < 0.001). Significant between-group differences were also observed in other outcomes, including postoperative pain severity, opioid consumption, mechanical ventilation time, and hospital length of stay, in favor of the ESPB group. Preemptive ESPB appears to decrease the risk of CPSP development in patients undergoing OP-CABG. Reduced acute pain severity and shorter mechanical ventilation times and hospital stays should improve patients’ satisfaction and reduce perioperative complications.

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A Prospective Cohort Study: Erector Spinae Plane Block Decreases Chronic Postoperative Pain Severity in Patients Undergoing Coronary Artery Bypass Grafting

September 2022

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16 Reads

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3 Citations

Up to 56% of patients develop chronic postsurgical pain (CPSP) after coronary artery bypass grafting (CABG). CPSP can affect patients’ moods and decrease daily activities. The primary aim of this study was to investigate CPSP severity in patients following off-pump (OP)-CABG using the Neuropathic Pain Symptom Inventory (NPSI). This was a prospective cohort study conducted in a cardiac surgery department of a teaching hospital. Patients undergoing OP-CABG were enrolled in an erector spinae plane block (ESPB) group (n = 27) or a control (CON) group (n = 24). Before the induction of general anesthesia, ESPB was performed on both sides under ultrasound guidance using 0.375% ropivacaine. The secondary outcomes included cumulative oxycodone consumption, acute pain intensity, mechanical ventilation time, hospital length of stay, and postoperative complications. CPSP intensity was lower in the ESPB group than in the CON group 1, 3, and 6 months postsurgery (p < 0.001). Significant between-group differences were also observed in other outcomes, including postoperative pain severity, opioid consumption, mechanical ventilation time, and hospital length of stay in favor of the ESPB group. Preemptive ESPB appears to decrease the risk of CPSP development in patients undergoing OP-CABG. Reduced acute pain severity and shorter mechanical ventilation times and hospital stays should improve patients’ satisfaction and reduce perioperative complications.


Development and validation of a stress response measure: the Daily Stress Response Scale (DSRS)

June 2022

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149 Reads

Health Psychology Report

Background To date, there is a lack of measures for capturing a broad spectrum of psychophysiological stress reactions that can be administered on a daily basis and in different contexts. A need for such a measure is especially salient in settings where stress processes can unfold momentarily and substantially fluctuate daily. Therefore, the main aim of the current study was to develop and validate the Daily Stress Response Scale (DSRS), an instrument capturing a broad spectrum of psycho-physiological stress reactions that can be administered in real time and in different contexts. Participants and procedure The study was conducted in the early stages of the COVID-19 pandemic in Europe. Participants were 7228 (81% female) Polish university students. The data were collected anonymously through self-completion questionnaires. The DSRS was subject to confirmatory factor analyses (CFA). Results The DSRS is a 30-item, easy-to-use stress response measure with excellent psychometric properties. Based on CFA results, the scale consists of two subscales, psychological and physiological stress response, which form associations with related external criteria. Conclusions The DSRS is a reliable and valid measure of psychological and physiological stress reactions that can be used to assess the stress response to daily stressors, including those of an acute nature, such as a crisis, trauma, or surgery.


Development and validation of a stress response measure: The Daily Stress Response Scale (DSRS)

May 2022

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356 Reads

Health Psychology Report

Background: To date, there is a lack of measures for capturing a broad spectrum of psychophysiological stress reactions that can be administered on a daily basis and in different contexts. A need for such a measure is especially salient in settings where stress processes can unfold momentarily and substantially fluctuate daily. Therefore, the main aim of the current study was to develop and validate the Daily Stress Response Scale (DSRS), an instrument capturing a broad spectrum of psychophysiological stress reactions that can be administered in real time and in different contexts. Participants and procedure: The study was conducted in the early stages of the COVID-19 pandemic in Europe. Participants were 7228 (81% female) Polish university students. The data were collected anonymously through self-completion questionnaires. The DSRS was subject to confirmatory factor analyses (CFA). Results: The DSRS is a 30-item, easy-to-use stress response measure with acceptable psychometric properties. Based on CFA results, the scale consists of two subscales, psychological and physiological stress response, which form associations with related external criteria. Conclusions: The DSRS is a reliable and valid measure of psychological and physiological stress reactions that can be used to assess stress response to daily stressors, including those of acute nature, such as a crisis, trauma, or surgery.


Figure 2. Study flowchart.
Patient demographics and indications for cesarean section.
Pain upon activity.
Number of patients with persistent pain.
Quadratus Lumborum and Transversus Abdominis Plane Blocks and Their Impact on Acute and Chronic Pain in Patients after Cesarean Section: A Randomized Controlled Study

March 2021

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72 Reads

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31 Citations

Background: Severe postoperative pain is a significant problem after cesarean sections. Methods: This study was a randomized, controlled trial of 105 patients conducted in two hospitals. All patients were anesthetized spinally for elective cesarean section. Each participant was randomly allocated to one of three study groups: the quadratus lumborum block (QLB) group, the transversus abdominis plane block (TAPB) group, or the control (CON) group. The primary outcome of this study determined acute pain intensity on the visual analog scale (VAS). The secondary outcomes determined morphine consumption and chronic pain evaluation according to the Neuropathic Pain Symptom Inventory (NPSI) after hospital discharge. Results: At rest, the pain intensity was significantly higher in the CON group than in the QLB and TAPB groups at hours two and eight. Upon activity, the pain in the control subjects was more severe than in the QLB and TAPB groups in three and two of five measurements, respectively. Moreover, morphine consumption was significantly lower in the QLB (9 (5-10)) and TAPB (10 (6-14)) groups than in the CON (16 (11-19)) group. Persistent postoperative pain was significantly lower in the QLB group than in the CON group at months one and six following hospital discharge. Conclusions: Both the QLB and TAPB can improve pain management after cesarean delivery. Moreover, the QLB might reduce the severity of persistent postoperative pain months after cesarean section.


Figure 1. A 2 (Gender) by 5 (Study Stages) ANOVA Results
A repeated cross-sectional survey assessing university students’ stress, depression, anxiety, and suicidality in the early stages of the COVID-19 pandemic in Poland

September 2020

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487 Reads

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296 Citations

Psychological Medicine

Background The time of widespread outbreaks of infectious diseases can lead to elevated stress and mental health problems among all persons affected, and in particular those sub-groups of the population that are at an increased risk of mental health problems. One such vulnerable group constitutes university students. The aim of this study is to assess stress, depression, anxiety, and suicidality among different groups of university students (medical, psychology, and other). Methods Using a repeated cross-sectional study design, we collected survey data among a large sample of 7228 university students from Poland (mean age = 22.78, s.d. = 4.40; 81% female). Data were collected in five waves, during the first 2 months of the COVID-19 pandemic in Europe (March and April 2020). Results The results demonstrate a significant increase in depression levels as the pandemic was progressing. We also found that female students scored significantly higher than male students on depression, anxiety, and stress. Psychology students recorded the lowest scores on depression and anxiety. Young adult students (aged 18–24 years) had more symptoms of depression, anxiety, and suicidality than adult students (⩾25 years). Conclusions These results provide insights into stress and mental health among university students during the early stages of the COVID-19 pandemic. Findings can be used for a more effective identification of students who may struggle during next stages of the pandemic and future crises.


Figure 2. HIF-1α upregulation (A) and nuclear translocation (B) upon stimulation with hypoxia-mimetic agent cobalt chloride and the effect of remifentanil preconditioning in HCM cells. (A) Western blot analysis of the levels of HIF-1α. Data were normalized to β-actin. (B) Immunofluorescence analysis of cellular localization of HIF-1α (red). Representative microphotographs are shown, objective 10×, scale bars 10 μm. F-actin staining (green) and nucleus staining (blue) were also considered. Nuclear immunosignals of HIF-1α were calculated [%]. Bars indicate SD, n = 3, *** p < 0.001 compared to normoxic control (CTR), ### p < 0.001 compared to hypoxic control (CTR) (ANOVA and Dunnett's a posteriori test). CTR, control; R, remifentanil preconditioning.
Figure 3. Hypoxia-induced oxidative stress (A, B), nitrosative stress (C), adaptive oxidative stress, heat shock/chaperone and autophagybased responses (D, E), and the effect of remifentanil preconditioning in HCM cells. (A) Superoxide levels were measured using Muse ® Cell Analyzer and Muse ® Oxidative Stress Kit. Representative histograms are presented. (B) Protein carbonylation was investigated using OxyBlot ™ Protein Oxidation Detection Kit. A negative control without DNPH derivatization (lane DNPH(-)) and a positive control with a mixture of standard proteins with attached DNP residues (lane M) are also shown. The levels of oxidative protein damage were normalized and protein carbonylation during normoxic control conditions was considered as 1. (C) Nitric oxide levels were investigated using Muse ® Cell Analyzer and Muse ® Nitric Oxide Kit. Representative dot-plots are also shown. (D) Western blot analysis of the levels of LC3B, SOD1, HSP70 and HSP90. Data were normalized to β-actin. (E) Immunofluorescence analysis of cellular localization of LC3B (red). Representative microphotographs are shown, objective 10×, scale bars 15 μm. F-actin staining (green) and nucleus staining (blue) were also considered. Bars indicate SD, n = 3, *** p < 0.001, ** p < 0.01, * p < 0.05 compared to normoxic control (CTR), ### p < 0.001, ## p < 0.01, # p < 0.05 compared to hypoxic control (CTR) (ANOVA and Dunnett's a posteriori test). CTR, control; R, remifentanil preconditioning.
Figure 4. Remifentanil preconditioning protects against hypoxia-induced senescence in HCM cells. (A) Senescence-associated β-galactosidase (SA-β-gal) activity. Representative microphotographs are shown. Scale bars 50 μm, objective 20×. The levels of SA-β-gal positive (blue) and negative (no blue) cells were calculated [%]. (B) Western blot analysis of the levels of cell cycle inhibitor p21. Data were normalized to β-actin. (C) Western blot analysis of the levels of pro-inflammatory cytokine IL-8. IL-8 levels in supernatants (Myocyte Growth Medium, MGM) were calculated per 10000 cells. Bars indicate SD, n = 3, *** p < 0.001 compared to normoxic control (CTR), ### p < 0.001, ## p < 0.01 compared to hypoxic control (CTR) (ANOVA and Dunnett's a posteriori test). CTR, control; R, remifentanil preconditioning.
Figure 5. Remifentanil preconditioning protects against hypoxia-induced necroptosis in HCM cells. (A, B) Western blot analysis
Figure 6. Remifentanil preconditioning protects against hypoxia-induced cellular senescence and necroptosis in human cardiac myocytes that is achieved by remifentanil preconditioning-mediated decrease in the levels of cell cycle inhibitor p21, secretion of IL-8 proinflammatory cytokine as a part of senescence-associated secretory phenotype (SASP) and phospho-MLKL-based necroptotic signaling. Cellular senescence and necroptosis may be due to hypoxia-mediated oxidative stress (not shown).
Remifentanil preconditioning protects against hypoxia-induced senescence and necroptosis in human cardiac myocytes in vitro

June 2020

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119 Reads

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25 Citations

Aging

Remifentanil and other opioids are suggested to be protective against ischemia-reperfusion injury in animal models and coronary artery bypass surgery patients, however the molecular basis of such protection is far from being understood. In the present study, we have used a model of human cardiomyocytes treated with the hypoxia-mimetic agent cobalt chloride to investigate remifentanil preconditioning-based adaptive responses and underlying mechanisms. Hypoxic conditions promoted oxidative and nitrosative stress, p21-mediated cellular senescence and the activation of necroptotic pathway that was accompanied by a 2.2-, 9.6- and 8.2-fold increase in phosphorylation status of mixed lineage kinase domain-like pseudokinase (MLKL) and release of pro-inflammatory cytokine IL-8 and cardiac troponin I, a marker of myocardial damage, respectively. Remifentanil preconditioning was able to lower hypoxia-mediated protein carbonylation and limit MLKL-based signaling and pro-inflammatory response to almost normoxic control levels, and decrease hypoxia-induced pro-senescent activity of about 21% compared to control hypoxic conditions. In summary, we have shown for the first time that remifentanil can protect human cardiomyocytes against hypoxia-induced cellular senescence and necroptosis that may have importance with respect to the use of remifentanil to diminish myocardial ischemia and reperfusion injury in patients undergoing cardiac surgery.


Citations (11)


... 70 A study in Poland suggested that mothers previously experiencing IPV was a risk factor for their use of harsh parenting only when other risk factors for IPV and child maltreatment were present, including mental distress. 71 Although much less explored, men's perpetration of IPV has also been associated with harsh parenting. 72 ...

Reference:

IMPROVING THE MENTAL HEALTH OF PARENTS AND CAREGIVERS AS A STRATEGY TO PREVENT FAMILY VIOLENCE: WHAT DOES THE EVIDENCE SUGGEST?
Testing the spillover effect of intimate partner violence (IPV) victimisation on emotionally abusive and harsh parenting practices: The application of propensity score matching
  • Citing Article
  • May 2024

... International research papers/documents show that these prevention measures have increased stress and anxiety levels and the number of cases of depression (Debowska, 2020). This fact had a considerable effect especially among the students of the physical education faculties, who could no longer support/ practice their sports activities. ...

Psychological Medicine A repeated cross-sectional survey assessing university students' stress, depression, anxiety, and suicidality in the early stages of the COVID-19 pandemic in Poland
  • Citing Article
  • January 2024

... For example, even though sudden-onset anger attacks have been noted to be a feature of depression, and their occurrence linked to suicidal ideation (Jha, Fava, Minhajuddin, Fatt, Mischoulon, Cusin, et al. 2021;Jha, Fava, Minhajuddin, Fatt, Mischoulon, Wakhlu, et al. 2021) and persistent irritability (Jha, Fava, Minhajuddin, Fatt, Mischoulon, Cusin, et al. 2021;Jha, Fava, Minhajuddin, Fatt, Mischoulon, Wakhlu, et al. 2021), there is yet to be any exploration of anger attacks and the microbiome or justice involvement. Microbial connections to commonly described phenomena, such as brain fog, should be scrutinised; the recent development of validated brain fog scales allows for this possibility (Jehangir et al. 2022;Debowska et al. 2024). Researchers should query environmental and socioeconomic (or, more broadly, exposome) factors that have been previously linked to criminal behaviour. ...

Brain Fog Scale (BFS): Scale development and validation
  • Citing Article
  • September 2023

Personality and Individual Differences

... 12 Pre-emptive ESPB appears to decrease the risk of CPSP development in patients undergoing off-pump coronary artery bypass grafting with median sternotomy. 13 In thoracic surgery, TPVB is effective in attenuating acute pain 14 and improving the quality of recovery at 24 and 48 hours following surgery, 15 but the incidence of CPSP at 3 or 6 months was not significantly reduced. 14 In breast surgery, TPVB was not effective in preventing CPSP at 3 months 16 17 but may prevent the transition from acute pain to the neuropathic phenotype of CPSP. ...

Erector Spinae Plane Block Decreases Chronic Postoperative Pain Severity in Patients Undergoing Coronary Artery Bypass Grafting—A Prospective Cohort Study

... Borys et al. [67], in an observational prospective study of 233 patients, did not find that fascial blocks (such as the transversus abdominis plane or QL) improved post-surgical pain compared to standard treatment. However, in a subsequent RCT by Borys et al. [68] involving 105 patients, those who received QLB experienced significantly less persistent postoperative pain at months one and six following hospital discharge than those in the control group. Both the QLB and transversus abdominis plane (TAP) blocks were effective at managing pain after cesarean delivery, with the QLB potentially reducing the severity of persistent postoperative pain months after the procedure. ...

Quadratus Lumborum and Transversus Abdominis Plane Blocks and Their Impact on Acute and Chronic Pain in Patients after Cesarean Section: A Randomized Controlled Study

... Young adults (aged [18][19][20][21][22][23][24][25][26][27][28] are particularly vulnerable to mental health issues during COVID-19. Previous studies indicate poorer mental health outcomes compared to other age groups (6). ...

A repeated cross-sectional survey assessing university students’ stress, depression, anxiety, and suicidality in the early stages of the COVID-19 pandemic in Poland

Psychological Medicine

... This is to cast a fresh light on therapeutical approach to SUD. Paradoxically, researchers have found that a preconditioning of one potent, short-acting synthetic opioid analgesic drug that is remifentanil could protect against hypoxiainduced cellular senescence (Lewinska et al., 2020). ...

Remifentanil preconditioning protects against hypoxia-induced senescence and necroptosis in human cardiac myocytes in vitro

Aging

... Contemporary fast-track cardiac anesthesia (FTCA) aims for tracheal extubation to occur within four hours post-surgery and discharge from the ICU within 24 h [5]. FTCA programs minimize variability in care and improve efficient use of resources without compromising clinical efficacy or patient safety outcomes [6][7][8][9][10]. The optimal pharmacological strategy for FTCA has not been established. ...

Implementation of Enhanced Recovery After Surgery (ERAS) protocol in off-pump coronary artery bypass graft surgery. A prospective cohort feasibility study

Anaesthesiology Intensive Therapy

... Off-pump coronary artery bypass grafting (CABG) is a minimally invasive procedure performed on a beating heart without cardiopulmonary bypass (CPB). Consequently, considerable hemodynamic fluctuations are common during the procedure (Go et al. 2013;Kurowicki et al. 2020). Traditionally, high doses of long-acting opioids were used to facilitate off-pump CABG procedure (Mathison et al. 2000). ...

Remifentanil and sevoflurane based anesthesia combined with bilateral erector spinae plane block in patients undergoing off-pump coronary artery bypass graft surgery

Videosurgery and Other Miniinvasive Techniques

... Therefore, reducing the duration of mechanical ventilation results in decreased length of stay in the intensive care unit and hospital [4,5]. It has been reported that ESP block in minimally invasive cardiac surgery shortens the time to extubation and intensive care unit discharge [6]. Similarly, continuous ESP block has been reported to reduce these durations in open heart surgery [7]. ...

Erector spinae-plane block as an analgesic alternative in patients undergoing mitral and/or tricuspid valve repair through a right mini-thoracotomy – an observational cohort study

Videosurgery and Other Miniinvasive Techniques