Bayanne Olabi's research while affiliated with The University of Edinburgh and other places

Publications (14)

Article
Full-text available
Background The authors sought to compare gray matter changes in First Episode Schizophrenia (FES) compared with Fronto-Temporal Lobar Degeneration (FTLD) using meta-analytic methods applied to neuro-imaging studies. Methods A systematic search was conducted for published, structural voxel-based morphometric MRI studies in patients with FES or FTLD...
Article
It is well established that schizophrenia is associated with structural brain abnormalities, but whether these are static or progress over time remains controversial. A systematic review of longitudinal volumetric studies using region-of-interest structural magnetic resonance imaging in patients with schizophrenia and healthy control subjects. The...
Article
A transcription regulatory complex (TRC) that includes Ets1, Ets2, PEA3 and β-catenin/T-cell factors regulates osteopontin (OPN) that is implicated in colorectal cancer (CRC) dissemination. The consistency of OPN transcriptional control between primary CRC and metastases is unclear. This study investigates expression and prognostic significance of...
Article
A diagnosis of schizophrenia, as in most of psychiatric practice, is made largely by eliciting symptoms with reference to subjective, albeit operationalized, criteria. This diagnosis then provides some rationale for management. Objective diagnostic and therapeutic tests are much more desirable, provided they are reliably measured and interpreted. D...
Article
Background Structural brain abnormalities have been described in borderline personality disorder (BPD), but previous studies have generally been small and have implicated different brain regions to varying extents. Method We therefore conducted a systematic review and meta-analysis of published volumetric region-of-interest structural magnetic reso...
Article
Full-text available
Displaced fractures of the lateral end of the clavicle in young patients have a high incidence of nonunion and a poor functional outcome after conservative management. Operative treatment is therefore usually recommended. However, current techniques may be associated with complications which require removal of the fixation device. We have evaluated...
Article
We treated 47 patients with a mean age of 57 years (22 to 88) who had a proximal humeral fracture in which there was a severe varus deformity, using a standard operative protocol of anatomical reduction, fixation with a locking plate and supplementation by structural allografts in unstable fractures. The functional and radiological outcomes were re...
Article
Individuals with borderline personality disorder (BPD) suffer from marked affective disturbance, an unstable sense of self, difficulty in interpersonal relationships and heightened impulsivity, leading to high rates of self-harm and suicide. Patients are often refractory to treatment and are at high risk for acute or dangerous presentations, with a...
Article
May be inaccurate in some ethnic groups, and better tests are needed The prevalence of type 2 diabetes varies greatly by ethnic group within and across countries. The most reliable data on the prevalence of diabetes are based on two hour plasma glucose values after an oral glucose tolerance test,1 which is currently the gold standard epidemiologic...
Article
Extrapancreatic organ dysfunction is the key determinant of mortality in acute pancreatitis (AP). This study aimed to document the frequency and duration of individual organ dysfunction in all fatalities caused by AP in a large, population-based cohort. All deaths caused by AP in Scotland between 2000 and 2006 inclusive were analysed (n = 1024). Th...
Article
Vestibular compensation after unilateral vestibular loss is a complex, multi-factored process involving synaptic and neuronal plasticity in many areas of the brain, and it is a challenge to identify the key sites of plasticity that determine the rate and extent of behavioural recovery. Experimental evidence strongly implicates the vestibular commis...

Citations

... Stress, or elevated levels of glucocorticoids (GCs), during critical developmental periods can program neuroendocrine and behavioral systems and increase the propensity for affective disorders later in life (Heim and Nemeroff, 2001; Heim et al, 2008; Seckl, 2008). Regardless of this evidence, synthetic GCs such as dexamethasone are often prescribed in pregnancies as a prophylactic treatment of intraventricular hemorrhage and respiratory distress syndrome associated with preterm delivery (NIH_Consens_Statement, 1994). ...
... In terms of medication, there are currently no FDA-approved pharmacological interventions for BPD or ASPD (Bellino et al., 2008). However, antidepressants, mood stabilizers, antipsychotics, and anxiolytics are commonly prescribed to reduce symptom severity (Olabi & Hall, 2010), prevent worsening of symptoms (Olabi & Hall, 2010), and decrease risk of suicide (Goodman et al., 2012). Psychotropics are often used in BPD, with polypharmacy playing a large role in symptom management. ...
... Furthermore, brain imaging studies of patients suffering from schizophrenia have identifi ed the structural and functional changes in the frontal and temporal lobes, even in the fi rst episode, and more extensive changes throughout the course of the illness [8,9]. It is noted that the overlapping symptoms of these two disorders indicate the dysfunction of similar brain systems and pathways. ...
... Magnetic resonance imaging (MRI) has revealed differences between healthy control subjects and BPD patients in regional brain volumes and white matter integrity in fronto-limbic regions. BPD patients have decreased gray matter volume of the anterior cingulate cortex (ACC), the hippocampus, the medial prefrontal cortex (mPFC), and the dorsolateral frontal cortex (dlPFC), while the findings for the amygdala are mixed (Brambilla et al. 2004;Denny et al. 2016;Hall et al. 2010;Kuhlmann et al. 2013;Minzenberg et al. 2008). Studies using diffusion tensor imaging show that BPD patients present with decreased fractional anisotropy (an indicator of diminished axonal integrity or fiber density) in the fornix, cingulum, corpus callosum, uncinate fasciculus, and prefrontal white matter fasciculi New et al. 2013;Lischke et al. 2015;Whalley et al. 2015;Gan et al. 2016). ...
... Converging evidence supports that structural brain abnormalities present at the first episode of psychosis (FEP) are the consequence of years-long deviant developmental processes that begin long before the first manifestations of psychosis emerge 1,2 . Some of these abnormalities seem to progress during the initial years and persist well into the more chronic phases of psychosis 3,4 . However, whether the changes are progressive or not remains unclear, and results from longitudinal magnetic resonance imaging studies are mixed 5 . ...
... The latter highlights that the approach from schizotypy opens the doors to low-cost, high-benefit research (Kline & Schiffman, 2014), since the use of subclinical and non-pathological populations has cemented advances for research on clinical, factorial fronts, risk, cognitive, brain structure, and even genetic factors of schizophrenia (Lawrie et al., 2011). ...
... Visualization of adjacency relations [an example adapted from an article ofMole et al. (2011) that is included in our benchmark]. In this example, there are 91 adjacency relations. ...
... A recent survey showed that the most common operative intervention was locking plate fixation (68%), although there was no clear consensus regarding other fixation methods [7]. New CC fixation techniques are now being used to repair unstable fractures [8]. CC fixation techniques using a suture button allow reconstruction of the CC ligament and can reinforce internal fixation and work as the primary stabilizer of the distal clavicle [9]. ...
... GABAergic neurons in the VN, an essential part of the vestibular commissure system, sent nerve fibers to innervate nuclei that control the extraocular muscle and participated in the vestibulo-ocular reflex pathway. Additionally, when the uniform linear motion was not enough to trigger the vestibulo-ocular reflex, the GABAergic commissure system induces a velocity storage mechanism to enhance the stimulation of the vestibuloocular reflex pathway to maintain balance and gaze stability ( Olabi et al., 2009). In addition, previous studies have shown that after receiving signals from vestibular end organs in the inner ear, the VN could innervate the ipsilateral 3N and contralateral 6N, eliciting the ipsilateral medial rectus and contralateral lateral rectus contract to produce an eye movement in the opposite direction from head movement (Scudder and Fuchs, 1992 (Shi et al., 2021). ...
... 1,2 However, because this type of fracture is more prevalent in patients with poor bone quality 3 and bone support, primary repair with LCP may fail because of fracture comminution, 4 leading to complications such as screw cutout, loss of reduction, and high reoperation rates. 5 To provide greater stability to osteosynthesis, various alternatives have been suggested, such as the addition of a structured bone graft 6 or cement to screws. 7 Gardner et al proposed the use of fibular allografts (FA) as a structural augmentation method. ...