Balázs Szigeti's research while affiliated with Imperial College London and other places

Publications (5)

Preprint
Microdosing is the practice of regularly using very low doses of psychedelic drugs. Anecdotal reports suggest that it may enhance well-being, creativity and cognition. Here, we use data from a self-blinding microdose trial, a large (n=240) placebo-controlled citizen science trial of microdosing to investigate whether tolerance develops during micro...
Preprint
In medical research, the gold standard experimental design is the blinded randomized controlled trial. Despite the central role of blinding, it is rare for trials to assess blinding integrity and to incorporate this information into the interpretation of results. Here we use computational modelling to show that the combination of weak blinding and...
Article
Full-text available
Microdosing is the practice of regularly using low doses of psychedelic drugs. Anecdotal reports suggest that microdosing enhances well-being and cognition; however, such accounts are potentially biased by the placebo effect. This study used a ‘self-blinding’ citizen science initiative, where participants were given online instructions on how to in...
Article
Full-text available
Microdosing is the practice of regularly using low doses of psychedelic drugs. Anecdotal reports suggest that microdosing enhances well-being and cognition; however, such accounts are potentially biased by the placebo effect. This study used a ‘self-blinding’ citizen science initiative, where participants were given online instructions on how to in...
Article
Background: Neuroimaging studies imply that the regular use of ±3,4-methylenedioxymethamphetamine (MDMA), the major constituent of ecstasy pills, alters the brain's serotonergic system in a dose-dependent manner. However, the relevance of these findings remains unclear due to limited knowledge about the ecstasy/MDMA use pattern of real-life users....

Citations

... Further support comes from the widely used practice of microdosing in which doses of psilocybin that are only a fraction (one tenth or less) of the psychedelic dose are taken by individuals in a nonmedicinal context. While results are not consistent and comprehensive studies are lacking, there is evidence that microdosing may have positive effects on mood, creative processes, and energy [168,169]. In a recent large internet-based study psilocybin was the most frequently microdosed psychedelic agent. ...
... Restrictive drug policies make placebo-controlled studies on CBMPs difficult and expensive to conduct in laboratory settings due to the need for home office licences and intensive regulatory oversight. Citizenscience approaches may help to overcome these challenges (48). Citizen science involves individuals implementing their own placebo control at home, using their own acquired medical cannabis products, following online instructions to conduct self experimentation over a given time period with self-reported clinical scales to assess the value of the intervention. ...
... Some studies do indicate adverse effects, with neuroimaging showing that regular use may alter the brain's serotonergic system in a dose-dependent manner (Reneman, de Win, van der Brink, Booij, & den Heeten, 2006;Roberts, Jones, & Montgomery, 2016). Szigeti, Winstock, Erritzoe, and Maier (2018), however, found that these studies focused on unusually heavy MDMA use. These may overestimate the extent of serotonergic alterations. ...