Bairong Shen's research while affiliated with Sichuan University and other places
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Publications (41)
Gastric cancer (GC) is the fifth-most prevalent and second-most deadly cancer worldwide. Due to the late onset of symptoms, GC is frequently treated at a mature stage. In order to improve the diagnostic and clinical decision-making processes, it is necessary to establish more specific and sensitive indicators valuable in the early detection of the...
New genes (or young genes) are structural novelties pivotal in mammalian evolution. Their phenotypic impact on humans, however, remains elusive due to the technical and ethical complexities in functional studies. Through combining gene age dating with Mendelian disease phenotyping, our research reveals that new genes associated with disease phenoty...
Diabetes-related pathophysiological alterations and various female reproductive difficulties were common in pregnant women with gestational diabetes mellitus (GDM), who had 21.1 million live births. Preeclampsia (PE), which increases maternal and fetal morbidity and mortality, affects approximately 3%-5% of pregnancies worldwide. Nevertheless, it i...
Background:
Bisphenol A (BPA), bisphenol S (BPS) and bisphenol F (BPF) are widely used in various consumer products. They are environmental contaminants with estrogenic properties that have been linked to various health outcomes. Understanding their impact with body composition is crucial for identifying potential health risks and developing preve...
Background
Preterm birth is the leading cause of perinatal morbidity and mortality. Despite evidence shows that imbalances in the maternal microbiome associates to the risk of preterm birth, the mechanisms underlying the association between a perturbed microbiota and preterm birth remain poorly understood.
Method
Applying shotgun metagenomic analy...
Reproductive health is a worldwide challenge, but it is of particular significance to women during their reproductive age. Several female reproductive problems, including polycystic ovary syndrome (PCOS) and endometriosis, affect about 10 % of women and have a negative impact on their health, fertility, and quality of life. Small, chemotactic, and...
Background
The development of digital technologies and the evolution of open innovation approaches have enabled the creation of diverse virtual organizations and enterprises coordinating their activities primarily online. The open innovation platform titled “International Natural Product Sciences Taskforce” (INPST) was established in 2018, to bring...
Background
The development of digital technologies and the evolution of open innovation approaches have enabled the creation of diverse virtual organizations and enterprises coordinating their activities primarily online. The open innovation platform titled “International Natural Product Sciences Taskforce” (INPST) was established in 2018, to bring...
Background
Electronic medical records (EMRs) of patients with lung cancer (LC) capture a variety of health factors. Understanding the distribution of these factors will help identify key factors for risk prediction in preventive screening for LC.
Objective
We aimed to generate an integrated biomedical graph from EMR data and Unified Medical Langua...
Background: The development of digital technologies and the evolution of open innovation approaches have enabled the creation of diverse virtual organizations and enterprises coordinating their activities primarily online. The open innovation platform titled "International Natural Product Sciences Taskforce" (INPST) was established in 2018, to brin...
Rhesus macaques (Macaca mulatta) are the most extensively studied nonhuman primate species for human biomedical modeling. However, little is known about the biological pattern of genome-wide structural variations (SVs) and the evolutionary forces underlying SVs. Here, we conducted genomic sequencing and analyses based on Nanopore long reads and Ill...
Rhesus macaques (Macaca mulatta) are the most extensively studied nonhuman primate species for human biomedical modeling. However, little is known about the biological pattern of genome-wide structural variations (SVs) and the evolutionary forces underlying SVs. Here, we conducted genomic sequencing and analyses based on Nanopore long reads and Ill...
Copper (Cu) could be seriously hazardous when present at excessive levels, despite its vital contribution to various cellular processes. Selenium-enriched yeast (SeY) was reported to improve the health and metabolic status in broiler chicken. Hence, our study was endeavored to illustrate the mitigating efficacy of SeY on Cu-induced hepatic and rena...
Natural substances originating from plants have long been used to treat neurodegenerative disorders (NDs). Parkinson’s disease (PD) is a ND. The deterioration and subsequent cognitive impairments of the midbrain nigral dopaminergic neurons distinguish by this characteristic. Various pathogenic mechanisms and critical components have been reported,...
Aims & objectives: To investigate DNA methylation patterns in asthenozoospermic and normozoospermic sperm and to explore the potential roles of differential methylations in the etiology of the disease. Materials & methods: The authors performed whole-genome bisulfite sequencing analysis between normozoospermic controls and asthenozoospermic individ...
![Cellular redox indicators’ derivation [27].](publication/362381280/figure/fig4/AS:11431281085517226@1663782457070/Cellular-redox-indicators-derivation-27_Q320.jpg)
Neurodegenerative disorders such as Alzheimer’s disease (AD) and Parkinson’s disease (PD) are becoming more frequent as the age increases. Contemporary therapies provide symptom resolution instead of targeting underlying pathological pathways. Consequently, there is considerable heterogeneity in response to treatment. Research has elucidated multip...
C. pluricaulis Choisy (C. pluricaulis), a perennial herb aka C. microphyllus Sieb. and C. Prostratus Forsk. is being used as a traditional folk medicine for a variety of ailments. In this article, we collected information about C. pluricaulis through electronic search using PubMed, SciFinder, Google Scholar, and Web of Science as well as network ph...
With the development of urbanization, artificial intelligence, communication technology, and the Internet of Things, cities have evolved a new ecology from traditional city structures, that is, smart city. Combining 5G and big data, the applications of smart cities have been extended to every aspect of residents' lives. Based on the popularization...
The pathogenic mechanism of viral infection is a complex process involving viral mutation, viral integration, and various aspects of the interaction between the viral genome and the host. Moreover, the virus mutation will lead to the failure of related vaccines, leading to the increasing of vaccine development costs and difficulties in virus preven...
The COVID-19 pandemic has resulted in unprecedented burden on global health and economic systems, promoting worldwide efforts to understand, control, and fight the disease. Due to the wide spectrum of clinical severity, effective risk factors, biomarkers, and models for predicting disease severity and mortality in COVID-19 patients are urgently nee...
Mitochondria play a critical role in neuron viability or death as it regulates energy metabolism and cell death pathways. They are essential for cellular energy metabolism, reactive oxygen species production, apoptosis, Ca++ homeostasis, aging, and regeneration. Mitophagy and mitochondrial dynamics are thus essential processes in the quality contro...
Infectious diseases remain an essential global challenge in public health. For instance, novel coronavirus (COVID-19) has resulted in significant negative impacts on public health, infecting more than 214 million people and causing 4.47 million deaths worldwide as of August 2021. Geographic Information Systems have played an essential role in manag...
For decades, the rapid increase in metabolic diseases has posed a global health challenge. Diabetes is one such critical metabolic disease. The active control of body weight, blood sugars, and the treatment of multiple risk factors (including lifestyle intervention and drug treatment) for impaired glucose tolerance and early diabetes stages, can de...
Cancer remains the main cause of death, and the burden of cancer incidence and mortality continues to grow rapidly, seriously affecting the quality of life (QoL) and life expectancy of cancer patients and survivors. In recent years, an increasing number of people are engaging in exercise with increased awareness of the safety and benefits of exerci...
Informatics in exercise medicine is an emerging field. Ontologies and knowledge graphs are important in informatics, but they have not yet been developed in exercise medicine. In this chapter, I first explain what an ontology is, what a knowledge graph is, and what their relationship is. Then I focus on ontology by introducing related research and...
The impact of the gut microbiota and physical activity (PA) on human health is well documented. Extensive research has indicated that the microbiota and PA work interactively to improve human health. However, deciphering a pathway to personal health through the vast ocean of biomedical multi-omics data is not straightforward. Therefore, in this cha...
Sports medicine has had considerable success in different domains, including injury prevention, disease treatment, and patient recovery. By integrating genetic and phenotype data, this research is primarily utilized to promote the development of sports medicine. Recently, studies have begun to focus on the genetic basis of sports phenotypes, and th...
According to the Global Burden of Disease Study, in the past 20 years, cardiovascular disease (CVD) has consistently ranked as the leading cause of human death and loss of healthy life. Regular and systematic physical exercise is a crucial treatment strategy for CVDs, and many evidence-based medical studies support its safety and effectiveness. The...
The proposal of P4 medicine has brought about a change in the current medical model. Patients pay greater attention to their participation in the medical process, and personalized medicine also plays an important role in the treatment process. The sedentary lifestyle of modern people has brought about an overall decline in their health condition. T...
Almost all physiological and biochemical processes in the human body follow a circadian rhythm. Studies have found that the biological rhythms of the human body, especially circadian rhythms, affect the capacity for and performance of exercise. Exercise also affects circadian rhythms. The circadian rhythm influences core body temperature, muscle st...
Physical activity (PA) boosts mental health and well-being in both healthy and diseased populations. As regards to the latter, its therapeutic effects have been noted in patients diagnosed with various neurodegenerative disorders, and in this chapter we summarize these effects. The neuroprotective effects of PA are conferred via improved neuronal h...
The emerging research field of exercise immunology is becoming an essential sub-discipline of exercise medicine. Many studies have revealed a strong association between physical exercise and human immune system function. Moderate daily exercise can enhance general immunity whereas individuals deficient in exercise or engaged in heavy training tend...
Systemic lupus erythematosus (SLE, OMIM 152700) is a rare autoimmune disease with high heritability that affects ~0.1% of the population. Previous studies have revealed several common variants with small effects in European and East Asian SLE patients. However, there is still no rare variant study on Chinese SLE patients using the whole-genome sequ...
As pointed out by many researchers in the last few decades, differential equations with fractional (non-integer) order differential operators, in comparison with classical integer order ones, have apparent advantages in modeling. A Caputo fractional order system of ordinary differential equations is introduced to model the virus infection at the po...
The ongoing pandemic of coronavirus disease 2019 (COVID19) caused by infection with human SARS-CoV-2 is a global threat to the human population. World effort has arisen toward the characterization of the origin and evolutionary features of this devastating virus. The development of high-throughput sequencing platforms has facilitated the surveillan...
Citations
... The first classification divides chemokines into four classes: CC, XC, CXC, and CX3C. Our most recent studies, which were published, provided further clarification on the categorization of the CXC chemokine family and their respective CXCR receptors [8,9]. In the second classification, the function of CXC chemokines and their receptors in inflammatory, homeostatic, and GC is most important [10,11]. ...
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... Plants are rich in secondary metabolites and antioxidants, and hence their pharmacological properties have been widely explored [16][17][18][19][20][21][22]. Besides, the conventional medicinal systems chiefly rely on the use of multiple natural product scaffolds for the development of a new drug, in an unmodified state or for-property optimization by modifying the natural-product pharmacophores [23,24]. As a reflection of the high significance of natural products for the discovery and development of new pharmaceuticals, a continual evaluation of medicinal plants as a source of new therapeutic agent is highly recognized [23,24]. ...
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... Continued research in virology and pharmacology will predictably lead to the identification of new molecular targets for clinical intervention, with the objective of developing new combined treatments that will produce therapeutic synergies in the future [31,32]. The importance of developing an integrated approach and networking in the study of natural products for advancing new therapies is essential, and The International Natural Product Sciences Taskforce's (INPST) use of digital communications tools is a clear example of this [33]. ...
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... Maintaining intestinal health is essential for the health status of poultry. When the body is in an oxidative stress state, there is an increase in MDA and the accumulation of ROS and a decrease in SOD, CAT, and GSH-Px, which aggregates the damage to cells and tissues, causing a series of health problems [23,24]. Excessive oxidative stress often induces inflammation [25] and promotes cells to produce inflammatory cytokines, such as IL-1β, IL-6, and TNF-α, and activate inflammatory responses [26]. ...
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... However, there were multiple cases among heterosexual patients as well, this being a reason which opposes the stigmatization of the MSM community. What is more, a bigger threat is represented by countries where hygiene is not up to the accepted standards, this matter should be addressed first, since the mpox DNA is also found in urine and faeces (Singla and Shen, 2022). ...
Reference: Monkeypox: a global health emergency
... The antioxidative, anti-inflammatory, anti-viral, antiparkinsonian, antibacterial, and antiparasitic attributes of a plethora of compounds, including but not limited to quercetin, resveratrol, curcumin, apigenin, lutein, luteolin, rutin, baicalein, naringenin, hesperidin, ursolic acid, and others, have been well documented [6][7][8][9][10]. Among such substances, lactoferrin, quercetin, curcumin, probiotics, zinc, vitamin C, and vitamin D have already entered clinical COVID-19 trials [11]. ...
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... Abnormal DNA methylation can cause male infertility by leading to abnormal sperm parameters (9), this has been observed in men with varicocele too (1,10,11). Previous studies have shown that the severity of varicocele can affect the extent of sperm DNA methylation alteration (1,12), which could be related to increased sperm DNA damage. ...
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... Aggregation and buildup of the ubiquitinated protein inclusion body TDP-43 in motor neurons are the neuropathological signs of ALS (van Es et al., 2017). The pathogenesis of ALS is also tightly linked to aging, oxidative stress (Aborode et al., 2022), RNA damage repair and axonal development, mitochondrial malfunction and autophagy, and acquired living conditions. And Diseases for which MT is currently used to treat. ...
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... Shankhpushpi (Convolvulus pluricaulis) has emerged as a promising natural plant in the treatment of a variety of inflammatory and neurological disorders over the last two decades. Sharma et al. [3] investigated and comprehensively reviewed the various health benefits of crude C. pluricaulis herb and its extracts, as well as metabolites, in alleviating inflammation, oxidative stress, stress, anxiety, and neurological disorders such as Alzheimer's, memory impairment, and sleep disorders. Several preclinical and clinical studies suggested the potential benefits of Shankhpushpi for neurological complications. ...
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... Bioinformatics technology is an interdisciplinary subject of biology and computer. It uses modern information technology to simulate and predict protein structure based on the analysis of a large number of data such as DNA sequencing and functional genome, and is used for drug design [8,9]. NR5A2 (nuclear receptor subfamily 5 group A member 2) is A protein-coding gene and A lone nuclear receptor that requires ligand-activated transcription factors [10]. ...
