B Bidet's research while affiliated with Université Paris-Sud 11 and other places
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Publications (3)
The autoimmune aetiology of type I diabetes has been well documented. We studied whether anti-insulin anaphylactic antibodies were present on the membrane of basophils from type I diabetics by the toluidine blue method (detecting basophil activation after stimulation by insulin). We observed that basophils of recently diagnosed insulin-dependent di...
Human basophil activation was demonstrated by histamine release (HR) and by the decrease of the toluidine blue-positive basophils (TB+). In four experimental systems, TB+ number decreased in the absence of HR (1) in basophils from atopic subjects stimulated by allergen concentrations below the threshold for HR, (2) in basophils sensitized by anti-2...
Citations
... Ainsi, la transmission de l'information dépendrait d'une agitation vigoureuse. (Beauvais et al., 1992). L'étude de la dégranulation des basophiles par les IgE ou par l'histamine à l'aide d'une méthode de coloration est donc partielle ou incomplète, et suggère plutôt l'étude de la perte de coloration des granules (Broch, 2002 ; site internet n°18). ...
... Children with SPD had more illnesses, but children with ASD had more ear infections and allergies. Allergies and food intolerances of many types have been a suspected factor in autism (Bidet et al., 1993). Although reports of ear infections vary by area and demographic groups, children with SPD and ASD demonstrate a large number which may suggest that this area is worth looking at in more depth as clinically we observe that both groups have vestibular problems which have been previously associated with incidence of ear infections (Schaaf, 1985) and that children with ASD are often observed to have the most signifi cant vestibular processing problems. ...
... Indeed, when detected, IgG3 responses generally paralleled IgG1, whereas IgG2 levels followed the IgG4 response in some individuals. The IgG1 dominance seen for GADA and IA-2A is consistent with previous reports examining ICA at onset of diabetes (43,44), whereas IgG4-IAA have been reported (45). The subclass distribution of GADA found in BABYDIAB offspring differs, however, from that recently reported for older first degree relatives, where using ELISA for Ab measurement, IgG2-and IgG4-GADA were frequently found in the absence of IgG1-GADA, particularly in relatives who had not progressed to disease (24). ...