Azam Sadat Mousavi's research while affiliated with Tehran University of Medical Sciences and other places

Publications (22)

Article
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Backgrounds: Total Pelvic Exenteration (TPE) is a radical operation for malignancies in which all of the organs inside the pelvic cavity, including the female reproductive organs, the lower urinary tract, and a part of the rectosigmoid are removed. In this study, we aimed to conduct a systematic review to assess the overall survival (OS) and disea...
Article
Full-text available
Background Epithelial ovarian cancer (EOC) is an extremely aggressive and lethal carcinoma. Specific data that identify high-risk groups with uterine involvement are not available. Thus, this study aimed to evaluate a gross number of women with EOC to obtain the frequency of uterine involvement and its risk factors. Methods This retrospective obse...
Article
Full-text available
Background Diabetes mellitus (DM) is associated with poorer outcomes in some cancers. Its effect on ovarian cancer is less clear. We consider the effect of DM on overall survival (OS) and progression free survival (PFS) in patients with epithelial ovarian cancer (EOC). Methods A retrospective cohort study of 215 patients with EOC diagnosed between...
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The aim of this study was to evaluate and compare the accuracy of diffusion-weighted imaging (DWI), apparent diffusion coefficient (ADC) value, and time-intensity curve (TIC) type analysis derived from dynamic contrast-enhanced MR imaging (DCE-MRI) in differentiating benign from malignant adnexal masses. 47 patients with 56 adnexal masses (27 malig...
Article
Gestational trophoblastic neoplasm (GTN) is a rare disease which is classified into high- and low-risk groups. While the high-risk patients require combination therapy, the low-risk groups respond to single-agent chemotherapy. We studied resistance to single-agent chemotherapy and its risk factors among the low-risk GTN patients in Iran. We followe...
Article
AimZinc sulfate is beneficial in the treatment of epithelial warts. We conducted this study to compare the efficacy of combination therapy of oral zinc sulfate with conventional treatments in the treatment of vulvar warts.Material and Methods This study was a randomized controlled trial. The sample size was 42 in each group. Women aged 20–50 years...
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Full-text available
β -human chorionic gonadotropin (HCG) level is not a reliable marker for early identification of persistent gestational trophoblastic neoplasia (GTN) after evacuation of hydatidiform mole. Thus, this study was conducted to evaluate β -HCG regression after evacuation as a predictive factor of malignant GTN in complete molar pregnancy. Methods. In th...
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Full-text available
Transvaginal Ultrasonography is a noninvasive and inexpensive medical imaging tool used for the diagnosis of various diseases. To identify an effective method to identify high-risk patients for developing malignancy after molar evacuation. A prospective serial assessment of 19 patients with gestational trophoblastic disease was performed. Clinical...
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Background: Recent studies have showed conservative management in selective patients with borderline and malignant ovarian tumors is safe; therefore this management is considered in patients with ovarian tumor who desire to preserve fertility. Objective: This study has been performed to evaluate the clinical outcome and fertility in patients with o...
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To determine the strength of correlation between colposcopic impression using Reid index and biopsy histology. In a colposcopy referral clinic in Tehran University, Iran. Colposcopy was carried out using Reid colposcopic index (RCI) scoring system and directed biopsy on 344 women between March 2004 and October 2005 by fellows supervised by a board-...
Article
To determine the ability of a preoperative serum CA125 to predict optimal primary tumor cytoreduction in patients with stage III and IV epithelial ovarian cancer (EOC). The records of patients with advanced stage who underwent primary surgery for EOC at Tehran University, Vali-Asr Hospital between 2000 and 2002 were reviewed. Inclusion criteria inc...
Article
Malignant melanoma of the uterine cervix is a rare neoplasm with poor prognosis. Diagnosis is confirmed by immunohistochemical methods and by exclusion of other primary sites of melanoma. In this paper, we are reporting a case of a 38-year-old patient with a malignant melanoma of the uterine cervix. Diagnosis was made by histological and immunohist...
Article
Sarcoma botryoides rarely arises in the uterine cervix. It usually presents in the adolescent age group. The peak incidence is in the second decade. A combined modality approach to treating rhabdomyosarcoma (RMS) has markedly improved survival. We present two cases of cervical RMS. One of them had a very aggressive clinical course. Two cases of RMS...
Article
Summary Epithelial ovarian cancer (EOC) is the leading cause of death from gynecologic malignancy. Many studies showed different effects of consolidation therapy in advanced EOC. This trial was conducted to evaluate results of 12 cycles single agent paclitaxel in patients treated with surgical debulking and 6 course of platinum based chemotherapy....

Citations

... Diabetes is a chronic systemic metabolic disease that affects the major metabolic pathway throughout the body. Several studies have demonstrated that diabetes was strongly associated with tumor progression and survival in various cancer types, including breast cancer [7], pancreatic cancer [8], gallbladder cancer [9], epithelial ovarian cancer [10], esophageal cancer [11,12], colorectal cancer [13,14], and lung cancer [15,16]. However, to the best of our knowledge, no study has investigated the relationship between diabetes and AC. ...
... The true utility of DWI and ADC maps is differentiating endometriosis and endometriomas from other pathology in the pelvis such malignancy, which has been shown to have significantly lower ADC values compared to benign entities (Figs. 8,9) [95][96][97][98]. This is especially useful as endometriosis is known to have a small risk of malignant transformation [99]. ...
... While in those patients who developed PGTD, both the pre-and post-evacuation DFV measurements remained low. Similar results were reported by Asmar et al., [2], Sun et al 2015 [14], Yalcin et al. [13], Malek et al. [16]. Yalcin et al [13] and Gungor et al. [17] who showed similar findings to ours regarding uterine artery Doppler indices before evacuation of the mole and associations with occurrence of PGTD. ...
... Studies have shown that in low-risk patients, the probability of changing from single-agent to combination chemotherapy due to drug resistance is 9-33% (7,8). The rate of resistance to first-line single-agent chemotherapy in low-risk GTN patients with a high FIGO/WHO prognostic score of 5-6 has been shown to be 14 times higher than that in patients with a low FIGO/WHO prognostic score of 0-4 (9). It is still controversial whether combination chemotherapy regimens work better. ...
... Meanwhile, improvement was observed in only 13% of the control patients [33]. Akhavan et al. showed that the relapse rate in patients with vulvar warts who had been treated with oral zinc sulfate was significantly lower than that in the control patients after six months [34]. In our study, the serum zinc levels of patients with and without a history of relapse showed no statistical difference. ...
... After adjustment for potentially confounding factors, there was no preoperative factor found to be independently associated with postmolar GTN. Previous studies demonstrated that hCG could be helpful in predicting postmolar GTN [5,17,19,21,23,25,32]. However, there was variation in the timing and hCG used among studies, such as single value, hCG ratio, nomogram, or regression curve. ...
... The appropriate treatment for cervical botryoid sarcoma is still debatable. Surgical procedures include simple hysterectomies, radical hysterectomies with or without lymphadenectomy, and more conservative procedures such as polypectomies or local excisions [11,12]. ...
... Cervical melanoma is a very rare histopathologic subtype of primary cervical cancer. In a few case reports, cervical melanoma was managed similarly to cervical carcinoma (26)(27)(28)(29). For curative-intent treatment, radical resection is the main surgical approach. ...
... The study reported that the AUC of preoperative CA125 predictive optimal surgical cytoreduction was 0.57-0.83 [26][27][28][29][30], prediction efficiency is either weak or high [25,31,32]. There are few studies on HE4 in predicting primary optimal surgical cytoreduction of advanced ovarian cancer, but almost all studies assessing the predictive value of serum HE4 level in predicting surgical outcome for ovarian cancer have confirmed the effectiveness of HE4. ...
... Wide ranges of sensitivity and specificity rates are reported in the detection of HSIL, at 30-90% and 44-97%, respectively [15][16][17]. A total of 30% of HSILs are reported to be missed by colposcopy alone [18]. In order not to overlook HSIL or cervical cancer, a colposcopy-directed biopsy is necessary, which is an invasive procedure that is associated with certain complications, including pain, bleeding, and fibrosis [10]. ...