Ayşe Neslin Akkoca’s research while affiliated with Iskenderun State Hospital and other places

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Publications (17)


Table 1 . Excisional biopsy results of patients with lympadenopathy 
Evaluation of peripheral lymphadenopathy with excisional biopsy: Six-year experience
  • Article
  • Full-text available

November 2015

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626 Reads

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46 Citations

International Journal of Clinical and Experimental Pathology

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Ayşe Neslin Akkoca

Background: Lymphadenopathy (LAP) may be the first symptom of many diseases. We aimed to investigate peripheral LAP results taken by excisional biopsy. Methods: Histopathological examination of 185 lymph node biopsy specimens were evaluated between January 2009 and April 2015 in Istanbul Private Ekin Pathology Laboratory, retrospectively. Results: The average age of patients ranged from 1 to 86 was 41.01 ± 20.62 years. 87 of were female, 98 of male. 62 (33.5%) of excisional biopsy materials were benign lesions and 123 (66.5%) of malignant. Benign lesions were consisted of reactive hyperplasia, cat-scratch disease, toxoplasmosis, necrotizing/non-necrotizing granulomatous. Of these patients, 40 had nodes with reactive hyperplasia (15 female/25 male, mean age: 27.35 y), 14 had necrotizing granulomatous disease (9 female/5 male, mean age: 39.86 y), 2 non-necrotizing granulomatous disease (1 female/1 male mean age: 43 y), 4 had cat-scratch disease (1 female/3 male mean age: 54.25 y), 1 toxoplasmosis (26 y, female), 1 Kikuchi disease (25 y, female). In the evaluation of malign lesions; 38 were Hodgkin lymphoma (HL) (20.5%, 17 female/21 male, mean age: 34.89 y) 77 had non-Hodgkin lymphoma (NHL) (41.6%, 37 female/40 male, mean age: 52.26 y), 8 metastasis (4.3%, 5 female/3 male, mean age: 53.5 y). Reactive LAP observed most common in cervical region, NHL in axillary-abdomen-inguinal-mediastinum and HL in the supraclavicular region. Conclusion: Excisional biopsy can be applied safely with minimal morbidity and mortality and a gold standard diagnostic method for LAP. Although LAP is mostly related with benign lesions, malignancy should be kept in mind in differential diagnosis.

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Relationship of Recurrent Aphthous Stomatitis with Nutritional Habits

November 2015

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74 Reads

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1 Citation

The Annals of Clinical and Analytical Medicine

Aim: In this study we investigated the frequency and relationship of recurrent aphthous stomatitis(RAS) with family history, personal variables such as weight, heigt, antibiotic usage, teeth brush and nutritional habits in geriatric patients. Material and Method: The patients over 65 years old were included in the study. Before examination, the definition of recurrent oral aphthous ulcers and a visual informatory form including photographs were presented to the subjects. The age, sex, height, weight of the subjects were noted on a chart. Then the history of recurrent oral aphthous ulcerations were asked and if present the frequency of the ulcers, the type of the ulcers, the localization of the ulcers, the subjective symptome of the ulcers, familial history for the ulcers, frequency of antibiotic usage, teeth brush habits and nutritional habits were examined by a questionnaire. Results: Eighty subjects completed the study. 31.25% of subjects declared recurrent oral ulcer history. Pain was the leading subjective symptome declared by 44% of the subjects. 15% of the subjects had a family history for recurrent oral ulcers. There was no correlation between frequency of antibiotic usage and history of RAS. Also, there was no correlation between teeth brush habits and history of RAS. The RAS group consumed tea and fizzdrinks more frequently whereas they consumed milk and milk products, walnut, bread and other grains more rarely. Discussion: Nutritional habits may have a role on ocurrence of reccurrent oral aphthous ulcerations. So we are of the opinion that the elimination of the risky nourishments and the addition of the protective nourishments may be the first step of the treatment period. © 2015, Journal of Clinical and Analytical Medicine. All rights reserved.


Pattern of primary tumors and tumor-like lesions of bone in children: Retrospective survey of biopsy results

September 2015

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16 Reads

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17 Citations

International Journal of Clinical and Experimental Pathology

Background: Although primary bone tumors are relatively uncommon, they constitute the most important tumors in patients less than 20 years. We aimed to determine the frequencies of primary bone tumors and tumor-like lesions of bone and the anatomical sites of their occurrence. Methods: A retrospective review of histopathology reports of all bone specimens received in a private pathology laboratory in Istanbul between 2009 and 2015. Results: A total of 57 patients (aged 5 to 18 years) with a mean of 13.12 years were studied. Thirty five patients (61.4%) were males and 22 (38.6%) were females. Fifty five (94.4%) of the tumors were benign. Osteochondroma was the commonest tumor accounting for 31 cases (54.3%) followed by osteoid osteoma, 9 cases (15.7%). Chondrosarcoma observed in two patients and Ewing sarcoma in one patient as malignant tumors. Of the 57 bone tumors 13 (22.8%) occurred in the upper extremities, while 44 (77.2%) were in the lower extremities. Proximal humerus was the most commonly involved site in upper extremity tumors, with osteochondromas representing the most frequent type of tumor (4 patients; 7%). In the lower extremities again osteochondromas were the most common type of tumor (8 cases, 14%), with the femur being the most common site of involvement (18 patients, 31.5%). Of the patients with tumor-like lesions; four patients had fibrous dysplasia, 4 patients had non-ossified fibromas, 4 patients had simple bone cysts and 3 had aneurismal bone cyst. Conclusion: This study showed that primary bone tumors were mainly benign, settled predominantly in the lower extremities mostly in the femur with a male preponderance. Osteochondroma was the most common benign bone tumor. We didn't observed osteosarcoma, which is the most frequent malignant bone tumor.


Incomplete Kawasaki Disease Presenting with Pancarditis and Pericardial Effusion

June 2015

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237 Reads

Mustafa Kemal Üniversitesi Tıp Dergisi

Kawasaki disease is an acute self-limiting systemic vasculitis. Although its etiology is unknown, some infectious agents are strongly suspected. Untreated patients may develop severe complications, such as coronary artery aneurysm, congestive heart failure, myocardial infarction, and cardiac dysrhythmia. In this report, eight years-old girl, diagnosed as incomplete KD with pericardial effusion without conjunctivitis and lymphadenopathy, was presented.Key words: Incomplete Kawasaki disease, Pancarditis, Pericardial effusion


Lower gastrointestinal endoscopic biopsy results
Age distribution according to biopsy results
Evaluation of results of lower gastrointestinal endoscopic biopsi

December 2014

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75 Reads

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5 Citations

International Journal of Clinical and Experimental Medicine

The endoscopic examination is widely used and also the the gold standard in lower gastrointestinal system (LGIS) in the diagnosis and treatment of mucosal pathology. Colon and rectum often hosts premalignant lesions and relatively easily accessible organs. Therefore, colorectal cancer (CRC) is a early detectable disease. And to prevent the development of CRC and to capture at early stage the screening tests such as screening endoscopy are used. In our study was aimed to evaluate the biopsy results of the lower gastrointestinal endoscopy. The lower gastrointestinal endoscopy (LGE) biopsy results of 135 cases and demographic characteristics of the patients were evaluated retrospectively who admitted to Department of Pathology between January 2013-November 2013. 135 patients enrolled in the study, 89 (65.92%) of male and 46 (34.07%) were female. The age of patients were between 15 and 82 with a mean age of 53.00 ± 14.6. 85 of 135 cases (62.96%) were colitis, 3 (2.22%) were hyperplastic polyps, 22 (16.30%) were tubular adenoma, 15 (11.11%) of them tubulovillous adenoma, 1 (0%, 74) of submucosal lipoma, 9 (6.67%) patients were diagnosed with cancer. All of the cancer cases were in adenocarcinoma histology, one of developing from villous adenoma, one of them from tübülovillous adenoma. Cases of adenomas were included to only cancer groups because there is no duplication of data. Colonoscopy in the detection of both benign and malignant LGIS pathologies is the gold standard method. The upper and lower gastrointestinal endoscopy(LGE) must be remembered as a reliable method in the population, with a low complication rate and high diagnosis rate and when there is clinical necessity gastrointestinal endoscopy should not be avoided as planned.



Table 1. Lymph node involvement by gender 
Table 2 . Differentiation by gender
Table 3. Serosa involvement by gender 
Table 4. Modified Dukes Classification according to gender 
Table 5 . TNM classification by gender
TNM and Modified Dukes staging along with the demographic characteristics of patients with colorectal carcinoma

September 2014

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1,877 Reads

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68 Citations

International Journal of Clinical and Experimental Medicine

Aim: Colon adenocarcinoma, is the most common cancer in gastrointesinal system (GIS). The whole world is an important cause of morbidity and mortality. TNM and modified Dukes classification which has great importance in the diagnosis and treatment of Colorectal cancer (CRC). TNM and Modified Dukes classification results of histopathological examination and the demographic characteristics of patients and their relation were investigated. Materials and methods: Lower gastrointestinal operation results of 85 patients were examined accepted to clinical Pathology between January 1997-November 2013. Colon cancer had been diagnosed at 85 patients with pathology materials and staging was done according to the TNM and Modified Duke classification. The demographic characteristics of patients, differentiation grade, lymph node involvement, serous involvement were evaluated retrospectively. Results: In this study 37 patients (43.52%) were men and 48 (56.47%) were women. Ages of patients were between 19 and 87 with a mean age of 57.31 ± 15.31. Lymph node, differentiation, serosa involvement, Modified Dukes and TNM classification was assessed according to sex and age. TNM classification by sex was not statistically significant (p > 0.05). There was no statistically significant relationship between age and differentiation (p = 0.085). Value of differentiation increased towards from 1 to 3 inversely proportional to age. So young patients defined as well-differentiated at the conclusion. Negative relationship was evaluated between age and TNM Class variables. As a result, the relationship between age and TNM was not significant (p > 0.05). However, with increasing age the degree of staging was also found to increase. TNM classification was associated with the differentiation and it was significant (p = 0.043). Conclusion: Colon cancer, when contracted at an early stage, it is suitable for surgery and curative treatment can be done with minimal morbidity and mortality. However, some of the patients have advanced disease at diagnosis and their 5-year survival rate is only 8%. Every year there is prolongation of overall survival of colon cancer. It is so common cancer type so that determination of prognostic factors, disease staging and treatment strategy which affects survival is significant.


The analysis of 8-year data (2002-2010) of the tumor cases based on the pathology records of Abant Izzet Baysal University medical faculty department

September 2014

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12 Reads

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1 Citation

International Journal of Clinical and Experimental Medicine

Aim: Cancer is one of the most significant health problems throughout the world. An important aspect of measures against cancer is to determinate the extension and prevalence of the cancer. Understanding characteristics and behavior of cancer is the key issue in providing preventive steps and developing proper strategies in the concept of early diagnosis and treatment. The objective of this study was to determine the regional cancer incidence and cancer types based on the pathology records of Department of Pathology, Medical School, Abant Izzet Baysal University. Secondly. The aim was to discuss the properties of these cases with other similar reports both from Turkey and the world. Materials and methods: All pathology records of the cases were evaluated who diagnosed at The Department of Pathology, Medical School, Abant Izzet Baysal University between December 20, 2002 and December 31, 2010. The results were classified according to year, age, sex and organ systems. Statistical analyses were carried out using Open Office version 3.1 and PSPP 0.7.2. The duplication of data was particularly prevented by excluding the multiple records in the case of more than one biopsies of the same cancer in the same patient. Results: Totally 18654 pathology records were analyzed. The ratio of positive cases was 24.18% (4510/18654) of including all benign and malignant tumors. Among them 1984 (43.99%) were male and 2526 (56.01%) were female. On the other hand, malignant tumors constituted 33.35 % (1504/18654) of all cases and the percentage of male and female patients were 67.81 % (1020/1504) and 32.19 % (484/1504) respectively. The occurrence of malignant tumors was mostly seen between 60 and 69 age group, while the predominant age period was between 50 and 59 when considering both benign and malignant patients. Male patients had cancers mostly after 60 age group and the predominant period was between 60 and 69 ages. Considering the female patients only, they had more cancers between 10 and 60 age group than males, and the most prevalent period was between 40 and 49 years. The prevalence of both benign and malignant tumors with respect to their origin were skin( 30.15%), female genital tract (21.57%) and gastrointestinal system (12.92%). Considering only the malignant tumors, the distribution was as skin (21.07%), male genital tract (17.82%) and gastrointestinal tract (14.96%). On the other hand, the order of cancers was skin (31.29%), gastrointestinal tract (17.69%), male genital tract (14.81%) in male patients, while it was as female genital tract (38.50%), skin (29.30%), gastrointestinal tract (9.20%) for the female patients. Conclusion: Due to our datas, our results are similar to the results in Turkey and the World. The reason of the lower incidence of some tumors such as lung tumors which are much higher in Turkey and the world may depend on technical inadequacy due to our faculty's being a newly established one.


Table 1 . DOG1 relationship with other parameters
Table 2. 
Table 3. Distribution of patients 
Diagnostic and prognostic roles of DOG1 and Ki-67, in GIST patients with localized or advanced/metastatic disease

August 2014

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279 Reads

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38 Citations

International Journal of Clinical and Experimental Medicine

Aim: Gastrointestinal stromal tumor is the most common mesenchymal neoplasia in the gastrointestinal tract and has a broad spectrum of pathological patterns and also clinical features changing from benign to malignant. Although the well-characterized parameters to predict the outcome have been the size and the mitotic index of the tumor in the patients with early-staged disease, bulky recurrent or metastatic tumor, resistance to medical treatment and mutation analysis are the prognostic factors for advanced stage-GIST. The aim of this study is to investigate new and more practical tissue markers, such as DOG1 and Ki-67 to specify the GIST diagnosis and also to predict the outcome in GIST patients with both localized and advanced staged disease. Methods: For the last 14 years, from 1999 to 2013, 111 patients with a histopathological GIST diagnosis from the hospital files were enrolled to the study. In their parafin-embedded tissue samples, DOG1 and Ki-67 expressions were evaluated with immunohistochemisty by two independent pathologists from Cukurova University Medical Faculty. Patients were divided into two groups, the patients with localized disease treated by surgery and the patients with advanced/metastatic disease. DOG1 and Ki-67 expressions were corelated with other diagnostic and prognostic histopathological markers and also the clinical outcome in these two group of patients. Results: The specificity and the sensitivity of DOG1 in GIST diagnosis was found 94 and 43%, respectively. DOG1 expression was especially important in the diagnosis of c-kit negative cases. Although Ki-67 was not found a statistically significant prognostic factor for overall survival, it was strongly corelated with mitotic index which is a well-known standart prognostic factor for localized disease. Discussion: DOG1 seems to be an important diagnostic tool for clinically suspected GIST diagnosis in both advanced or early staged patients whose tumours are c-kit expression negative. On the other hand, Ki-67 can be a stronger candidate for prognostic factor instead of mitotic index to identify the proliferative cells out of mitotic phase but this statement needs be prospectively validated on studies with large number of patients.



Citations (12)


... These sites are tissues where B and T-cells interfere with antigens (1,2). More than one centimeter enlargement and changes in lymph node consistency are generally defined as lymphadenopathy (3,4). The most common location of lymphadenopathies is the head and neck region, followed by the inguinal region, and axilla. ...

Reference:

The Main Determinant of Operative Time in Diagnostic Lymphadenectomy: Lymph Node Depht
Evaluation of peripheral lymphadenopathy with excisional biopsy: Six-year experience

International Journal of Clinical and Experimental Pathology

... Osteosarcomas are identified more commonly in the metaphysis of long bones in the lower extremities of teen-aged patients but can occur in any bone, including craniofacial bones. Although the orbit is more commonly a metastatic Fibrous dysplasia: A intramedullary expansile fibrous dysplasia with relative radiopacity, gritty to cloud-like consistency, and poorly defined borders involving the right anterior skull base (CT angiography head, axial); B randomly arranged curvilinear woven bone trabeculae with inconspicuous osteoblastic rimming set in a moderately cellular fibroblastic stroma (H&E, 10x) focus for osteosarcoma, primary osteosarcoma of the orbit has been described [42][43][44] and represents the most common malignant bone tumor of the orbit [45]. Typically, patients present with a chronic dull pain in the affected bone that may suddenly worsen in severity [46]. ...

Pattern of primary tumors and tumor-like lesions of bone in children: Retrospective survey of biopsy results
  • Citing Article
  • September 2015

International Journal of Clinical and Experimental Pathology

... [11][12][13][14] In recent years, research has emphasized uncovering the involvement of Demodex mites in the etiology of AR. According to research conducted by Yengil et al. 8 involving 63 patients with allergic rhinitis (AR) and 65 healthy individuals, the prevalence of Demodex on the eyelashes and cheeks was examined in relation to AR. Four eyelashes were collected from each participant to assess the density of Demodex. ...

Relationship between demodex folliculorum and allergic rhinitis in adults

Acta Medica Mediterranea

... The effect of urinary incontinence in FSFI domains such as arousal, desire, lubrication, orgasm, satisfaction, and pain is still unclear, according to the international literature. In Akkoca's study, problems with lubrication, satisfaction, and desire were in connection with urinary incontinence, but no relationship was found between dyspareunia and incontinence [40]. Salonia et al. found that urinary incontinence has a negative effect on arousal and elevates the risk of painful intercourse [22]. ...

The prevalence of urinary incontinence, sexual dysfunction and quality of life in women of reproductive age admitted to urogynecology departments
  • Citing Article
  • January 2014

Acta Medica Mediterranea

... An increased levels of CD8+ T-lymphocytes and/or decreased CD4+ T-lymphocytes has been obsereved in patients with RAS (22). In the present study, the most common sites of aphthous ulcer were the lips and cheek mucosa, which confirms the results of the study by Ozler et al (24). ...

Relationship of Recurrent Aphthous Stomatitis with Nutritional Habits
  • Citing Article
  • November 2015

The Annals of Clinical and Analytical Medicine

... At the same time, although UI does not directly threaten women's lives, it can cause a decrease in self-confidence and social activities in women, deterioration in the quality of sexual life and sleep, a sense of embarrassment, depression, and negatively affect the quality of life. 4,18,[20][21][22][23][24][25][26] Since UI is a health problem that significantly affects the quality of life, the basic responsibilities of nurses are to prevent the development of incontinence and to take an active role in the care and treatment of women who have this problem. For this reason, nurses who aim to improve holistic care, human health, and quality of life should provide nursing care and education to women in line with preventive healthcare services. ...

Üriner İnkontinans Tarifleyen Kadınlarda Aile ve Enürezis Nokturna Öyküsü

Mustafa Kemal Üniversitesi Tıp Dergisi

... Polymerase Chain Reaction (PCR) method helps the identification of mycobacteria in a short time of 48 hours and it has sensitivity and specificity as 84% and 100% [7]. Culture remains the gold standard diagnostic test for tuberculosis and it has sensitivity and specificity as 63% and 98% [6,7]. ...

Primary Nasal Tuberculosis: Case Report
  • Citing Article
  • October 2014

American Journal of Health Research

... [5] The mucosal lesions can be patchy or diffuse, localized or widespread, or in the form of hyperemia, erosions, ulcers, diverticulum, polyps or masses. [6] Other indications for a colonoscopy include investigation of suspected colorectal malignancy, unexplained weight loss, unexplained anemia, iliac or lumbar pain/swelling, positive faecal occult blood test, abnormalities detected on other imaging tests such as double-contrast barium enema, abdominal ultrasonography, computed tomography scan, or magnetic resonance imaging. [4,7] Colonoscopy with mucosal biopsy however remains the gold standard procedure for diagnosing lower gastrointestinal disorders. ...

Evaluation of results of lower gastrointestinal endoscopic biopsi

International Journal of Clinical and Experimental Medicine

... [4] More than 95% of CRCs are of the adenocarcinoma type and are graded according to the appearance and differentiation of the glandular structures. [5] According to this distinction, there are 3 degrees of differentiationwell differentiated (Grade-I), moderately differentiated (Grade-II), and poorly differentiated (Grade-III). ...

TNM and Modified Dukes staging along with the demographic characteristics of patients with colorectal carcinoma

International Journal of Clinical and Experimental Medicine

... The expression pattern of DOG-1 in ICCs mirrors its presence in GISTs, suggesting a close relationship between DOG-1, ICCs, and GISTs. This association underscores the utility of DOG-1 in accurately diagnosing GISTs, even in cases where traditional markers like KIT may be negative [25,34,[41][42][43]. Our study revealed a prevalent DOG-1 expression in a significant proportion of the study group, counting for a prevalence of 92.86% (13 patients). ...

Diagnostic and prognostic roles of DOG1 and Ki-67, in GIST patients with localized or advanced/metastatic disease

International Journal of Clinical and Experimental Medicine