Ayesha Ijaz’s scientific contributions

Although diamond-like carbon-coated joint replacements are widely recommended for full bone replacements in humans, their clinical application is substantially limited by contamination with wear particles, specifically graphite nanoparticles, which are cytotoxic. This study was aimed at assessing the adverse effects of graphite oxide (GO) sheets on the blood and renal tissues of adult male albino rats. A total of 25 albino rats were procured from the Government College University Faisalabad, Punjab, Pakistan, and acclimated for 7 days in well-ventilated enclosures, after approval from the ethical committee at the University of Sialkot. The rats were randomly assigned to the following groups: a control group receiving no treatment, a vehicle control group receiving normal saline, and three treatment groups (G1, G2, and G3, administered GO nanosheets at doses of 5, 6, or 7 mg/kg body weight, respectively). Treatments were delivered through intraperitoneal injection on alternating days over 28 days. Animal mortality, hematological parameters, and kidney histology were assessed. The control and vehicle control groups showed normal findings, whereas the groups exposed to GO exhibited highly significant pathological changes in renal function tests (p<0.05). Histological alterations were more severe in the moderate- and high-dose treatment groups than the low-dose group, which displayed typical histological features. The treatment groups exhibited various histological changes, including vacuolation, renal fibrosis, inflammation, and tubular damage, which were significantly more pronounced in the G2 and G3 groups than the G1 group. Thus, exposure to GO sheets resulted in detrimental effects on renal tissues in albino rats. The findings suggested that the investigated doses of GO have detrimental effects on the health of living organisms.

Titanium dioxide nanoparticles (TiO2-NPs) are widely utilized as a whitish pigment with potential applications in various sectors, including cosmetics, pharmaceuticals, food production, textiles, and water treatment. They are commonly employed as a sanitizing agent for microorganism control. Due to their small size and expansive surface area, these nanoparticles can inflict severe toxic effects on various human organs and cause serious damage to the surrounding environment. This study investigated the gonadal toxicity induced by TiO2-NPs in male Sprague Dawley rats. Accordingly, TiO2-NPs were employed with an average particle size of 55 nm. Twenty-five adult male Sprague Dawley rats weighing 107 ± 120 g underwent a 7-day acclimatization period and were subsequently randomly divided into five groups: The Control group (C), which received no treatment; the saline-treated group (S), treated with normal saline; and three treatment groups (G1, G2, and G3), each consisting of five rats. The rats were exposed to different concentrations of TiO2-NPs for 28 days on alternate days, determined after establishing the LC50 value. TiO2 was administered intraperitoneally with injection at doses of 50, 90, and 130 mg/kg body weight. The blood samples were collected at the beginning and end of the experiment. The 28-day exposure results revealed severe histological damage in testicular tissues at high and medium doses compared to the control and saline-treated groups. These damages included widened lumen, basement membrane damage, necrosis, and vacuolation in the tissues, which were highly significant in both the G1 and G2 groups. This study demonstrates the toxic effects of titanium dioxide nanoparticles on the gonads of Sprague Dawley rats. It is concluded that the selected concentrations of TiO2 negatively impact the health of living organisms.

This examination is intended to investigate the water strider fauna and their phylogenetic relationship in Tehsil Wazirabad, Punjab, Pakistan. Being a decent predator of mosquitoes and successful bioindicator of substantial metal contamination it assumes the imperative job to keep up the manageability of the biological system. The examples of water strider bug were gathered from different oceanic locales during summer and spring from 2018-2019 in Wazirabad City. The type of water strider that was distinguished during this exploration is Aquarius adelaidis (Zettel) having a place with distinct genera Aquarius of the family Gerridae. It likewise uncovered that Aquarius adelaidis disengaged from Wazirabad area has homology a with arrangement of water strider detailed from Cyprus island situated in the northeastern piece of the Eastern Mediterranean. The arrangement examination found that cytochrome c oxidase subunit I is profoundly monitored locale inside all Aquarius species around the world, and is less inclined to varieties and transformations. Aquarius adelaidis is increasingly bountiful with 58.2% of complete assortment.

Nanotechnology and nanoscience and their wide uses in the biomedical due to the unique and novel properties of nanoparticles have become a spread field for research worldwide. The properties of nanoparticles based on the shape, size and the components. These days’ different nanoparticles are under investigation for their utilization in the biomedical science especially for the cancer therapeutics. This paper is prepared for the investigation of numerical simulation of nanoparticles affected by the micro-rotation by incorporating the chemical reaction impacts. Moreover, the convective boundary conditions are considered. First we convert the PDE’s into ODE’s by utilizing the suiss transformations. Further numerical technique applied for the graphs and numerical values of the energy and mass transportation. We recovered that the power index factor and magnetic effect increment diminishes the velocity distribution. The convective parameter increases the temperature distribution of the nanoliquid.