Avinash Khandelwal's research while affiliated with Howard Hughes Medical Institute and other places

Publications (3)

Preprint
Full-text available
Brains contain networks of interconnected neurons, so knowing the network architecture is essential for understanding brain function. We therefore mapped the synaptic-resolution connectome of an insect brain ( Drosophila larva) with rich behavior, including learning, value-computation, and action-selection, comprising 3,013 neurons and 544,000 syna...
Article
Full-text available
Sensory navigation results from coordinated transitions between distinct behavioral programs. During chemotaxis in the Drosophila melanogaster larva, the detection of positive odor gradients extends runs while negative gradients promote stops and turns. This algorithm represents a foundation for the control of sensory navigation across phyla. In th...
Preprint
Full-text available
The sense of smell enables animals to react to long-distance cues according to learned and innate valences. Here, we have mapped with electron microscopy the complete wiring diagram of the Drosophila larval antennal lobe, an olfactory neuropil similar to the vertebrate olfactory bulb. We found a canonical circuit with uniglomerular projection neuro...

Citations

... The utility of a connectome is that it reveals the synaptic connectivity of the neuronal cell types and circuits that give rise to animal behavior. While comprehensive connectomes have been mapped for small crawling animals like C. elegans (Cook et al., 2019) and the Drosophila larva (Winding et al., 2022), we currently lack a synapse-level wiring diagram of motor circuits for any limbed animal. Here, we provide a draft connectome of a female adult Drosophila VNC, a platform for proofreading the draft connectome to completion, and analysis of a circuit that coordinates the legs and wings during escape behavior. ...
... While the number of neurons that were targeted in our tested lines varies from one to seven pairs on average, and sometimes more, in the case when the lines label multiple neuron types, intersectional strategies can be used to further refine the expression patterns. In the larva, a volume of electron microscope data has been acquired and more than 60% of the nervous system has been reconstructed through collaborative efforts [10,21,22,24,25,27,29,[47][48][49]. The synaptic partners of the identified candidate neurons can therefore be further reconstructed in the electron microscopy volume. ...
... In flies, a group of neurons known as Pair 1 evoke stopping (Lee et al. 2021), although it is not known whether these neurons receive olfactory input. Another DN in larvae, known as PDM-DN, has been shown to evoke stop-turns and is required for proper olfactory navigation (Tastekin et al. 2018). Thus, DNs may be one locus where pausing behavior is initiated to obtain additional information about the odor environment. ...