Augusto Abade's research while affiliated with University of Coimbra and other places

... With respect to development patterns, when these subadults were compared to the skeletal growth profile of the CISC, constructed on the basis of femur diaphyseal length (Cunha et al., 1999), it became clear that both individuals were taller than an average 11-yearold child. This was particularly true for the SCV 2. The morphological evaluation of these skeletons for sex was inconclusive. ...

... This is because of their potential use in developing targeted therapeutic approaches for β-thalassemia, γ-globin, and Hb switching modifier genes [17]. Individuals who have severe hemoglobinopathies caused by βglobin chain disorders, such as β-thalassemia intermedia and major, typically, clinical phenotypes are inversely related to the degree of HbF expression retention [18]. The results of ARMS PCR analysis for the BCL11A gene showed that three genotypes, AA, AC, and CC were in βthalassemia major patients' samples with frequencies of 0.3, 0.6, and 0.1, respectively, and in control 0.1, 0.8, and 0.1, respectively. ...

... Other E1b1b subhaplogroups have a similar frequency in Africa and Europe (E1b1b-M78), with a high prevalence in North Africa, and in the Iberian Peninsula (E1b1b-M81) and in West Asia and Europe (E1b1b-M123) 41 . We believe that this higher frequency of E1b1b is due to the Portuguese influence in our population, since in a study conducted by Martiniano et al., E1b1b had the third-highest frequency (12.0%) in the studied Portuguese population 38 . ...

... For comparison purposes, and as there are few studies regarding African population for mtDNA total control region, the sequences of the studied population were reduced to HVI and HVII regions, to allow comparison with other populations studied for HVI and HVII regions. In this case, the population of Angolan immigrants living in Lisboa was compared with populations from Guinea Bissau [29], Cape Verde [33], Somalia [31], Ghana [32], Mozambique [38], S. Tome and Principe [48], Angola [42], indigenous Khoe-san [37], Bantu ethnic groups from Angola [35,36] and Cabinda [34], all of them with sequenced HVI and HVII regions (Table 3) (Fig. 2). These results culminate in a short distance between the population of Angolan immigrants living in Lisboa and Angolan, people living in Angola as well Bantu ethnic groups from Angola, giving information that the first one maintains the genetic information of its origin, although, nowadays, inhabiting a different geographic region. ...

... To better understand the genetic basis of metabolic syndrome, it is important to replicate association evaluations in independent studies worldwide. Indeed, previous studies [24][25] showed that T allele frequency is not uniform across the literature, varying from 0.269 until 0.402. Our results are slightly higher than those reported in these studies. ...

... As a consequence of the remoteness of the islands, the peopling process of the Azores was slow, lasting over two centuries (Mendonc ßa, 1996). Settlers arrived mostly from mainland Portugal and the neighbouring Madeiran archipelago, but there were also minor contributions from elsewhere in Europe (Flanders, Spain, Italy, France, England, Germany and Scotland) (Matos, 1989), which is corroborated by human genetic data (Santos et al., 2003(Santos et al., , 2006Montiel et al., 2005). Also, from the late 15th century onwards, due to its location in the middle of the Atlantic, the Azores started to play an essential role as a stop-over. ...

... 240 km) and mainland is much larger than that of Bioko. It is therefore expected that human movement between Bioko and the coast of Cameroon has been much more frequent since the island was first colonized by the Bubi ethnical group, at the end of the last glaciation [64]. Finally, although the existence of ITS1 hybrid forms was initially suggested in G. p. palpalis of Equatorial Guinea [11], this hypothesis was later rejected by the same authors using microsatellite markers [10]. ...

... The high genetic diversity of Tenerife and Lanzarote is attributed to the location of these islands in the routes of maritime expansion from Portugal, a circumstance similar to that of Flores (Azores) as observed by Smith et al. (1992) and Santos et al. (2005). A different situation was described for Tristan da Cunha, where the small number of surnames counted (1816-1908) is explained by its isolation (Roberts 1971, Thomas & Thompson 1984. ...

... Thus, children who embark on their life-path from a less advantageous intergenerational ''platform'' seem to be particularly vulnerable to circulatory disease and death over the life-course. Despite the fact that female-headed households have proved to be a powerful indicator of childhood deprivation throughout history (Horrell, Humphries, & Voth, 2001), only a handful of studies have investigated the long-term health consequences of such childhood social conditions (Abade & Bertranpetit, 1995;Lund, Christensen, Holstein, Due, & Osler, 2006;Modin, 2003;Preston, Hill, & Drevenstedt, 1998). These studies all demonstrate an increased risk of adult mortality among individuals who were born outside marriage in the nineteenth or early twentieth century. ...

... PSQI [32] is a self-rated questionnaire that evaluates sleep quality over a 1-month time interval; PSQI has already been applied to MJD patients with the aim of increasing knowledge on the impact of sleep disturbances on disease manifestations (e.g., [33]). Depressive symptoms have also been reported in MJD patients; indeed, the presence of moderate-to-severe depressive scores in nearly 34% of MJD patients has been described [34]. Depression scores have been shown to correlate with motor impairment in MJD patients, but whether depression is more reactive and not primarily related to the disease process is a matter of debate (e.g., [35]), reinforcing the need for studies with a larger number of patients. ...