Atsushi Tanaka's research while affiliated with Memorial Sloan Kettering Cancer Center and other places

Publications (7)

Article
Full-text available
Colorectal adenocarcinomas arise from luminal lining epithelium of the colorectal tract which is covered with highly glycosylated mucins. Mucin O-glycosylation is initiated by a family of polypeptide N-acteylgalactosaminyltransferases (GALNTs). This study examined GALNT6 protein expression in 679 colorectal tumors, including 574 early-stage and 105...
Article
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In a quest for prognostic biomarkers in early-stage colorectal cancer, we investigated NNMT (nicotinamide N-methyltransferase) in large cohorts of patients. Immunohistochemical examination of 679 patients illustrates that NNMT protein is predominantly expressed in the cancer stroma at varying levels, and about 20% of cancer tissues overexpress NNMT...
Article
Pancreatic neoplasms are heterogenous and have traditionally been classified by assessing their lines of cellular differentiation using histopathologic methods, particularly morphologic and immunohistochemical evaluation. These methods frequently identify overlapping differentiation along ductal, acinar, and neuroendocrine lines, raising diagnostic...
Article
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DEAD-box RNA helicase DDX21 (also named nucleolar RNA helicase 2) is a nuclear autoantigen with undefined roles in cancer. To explore possible roles of autoimmune recognition in cancer immunity, we examined DDX21 protein expression in colorectal cancer tissue and its association with patient clinical outcomes. Unbiased deep proteomic profiling of t...
Article
Full-text available
Colorectal cancers are among the most common cancers and a leading cause of cancer death. In our pursuit to discover molecular markers for better characterization and precision theranostics of these cancers, we first conducted global deep proteome analyses and identified maspin (serpin B5, peptidase inhibitor 5) as an upregulated protein in tumor t...
Article
Full-text available
Proteomic analyses indicate that STAT1 protein (signal transducer and activator of transcription 1 or transcription factor ISGF-3 components p91/p84) is upregulated in some colorectal cancers. This study examined 736 colorectal cancer patients for the expression of STAT1 protein in tissue specimens, including 614 early stage patients and 122 advanc...
Article
Colorectal cancer (CRC) is one of the most prevalent and lethal malignancies. Especially for early stage CRC, prognostic molecular markers are needed to guide therapy. In this study, we first extracted total proteomes from matched pairs of fresh cancer and benign mucosal tissues from 22 CRC patients. Global proteomic profiling with Fourier transfor...

Citations

... Moreover, stromal NNMT expression was positively related with the main unfavorable prognostic parameters, such as advanced TNM stage and the presence of lymph node/distant metastases, while a negative correlation emerged with survival of patients affected with early-stage disease. Taken together, these results make NNMT a promising biomarker for postoperative prognosis of CRC patients [97][98][99]. ...
... Previous research has indicated the role of these SFs in the development, progression, and prognosis of multiple tumors. [45][46][47][48][49] For example, EIF3A plays a pivotal role in the phenotype and prognosis of bladder cancer by affecting the transcriptome. 49 However, the roles of several other SFs in bladder cancer have not been discussed in previous studies. ...
... We found decreased RASAL2 expression in A549 xenograft tumors treated with QRHXF due to the RNA sequencing results. SerpinB5, also known as maspin [21] is a member of the serine protease inhibitor superfamily [22]. It is involved in many biological processes, including cell adhesion, apoptosis [23], protein degradation, oxidative stress [24], and embryonic development [25]. ...
... Recent studies have shown up-regulation of P-gp mediated by signal transducer and activator of transcription 1 (STAT1)-histone deacetylase 4 (HDAC4) in the etoposide-resistant human lung cancer cell line (A549RT-eto) [4]. STAT1 is one of the seven mammalian members of the STAT family and a master transcription factor for IFN-γ intracellular signaling, leading to anti-oncogenesis in part by upregulating caspases [5], cyclin-dependent kinase inhibitor 1A [6], and the IFN-regulatory Factor 1 (IRF1)/p53 pathway [7], while down-regulating the BCL2 family [8]. Recent reports have also shown that constitutive overexpression of STAT1 is correlated with protection of tumor cells from chemotherapeutic drugs such as doxorubicin [9] or cisplatin [10]. ...
... Colorectal cancer (CRC) accounts for ∼10% of all cancers diagnosed each year and cancer-related deaths worldwide [71]. Analysis of P4HA1 expression with immunohistochemistry of 599 early-stage CRC biopsies showed that patients with high P4HA1 expression had significantly shorter OS and DFS [72]. Depletion of P4HA1 leads to the decrease of CRC cells' growth, invasion, and tumor growth in xenograft models via inhibiting collagen synthesis. ...