Atsushi Iriki's research while affiliated with RIKEN and other places
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Publications (201)
Common marmosets have been widely used in biomedical research for years. Nutritional control is an important factor in managing their health, and insect intake would be beneficial for that purpose because common marmosets frequently feed on insects in natural habitats. Here, we examined the effect of enhanced insect feeding on the gut by analysing...
A multimethod archaeometry study (zooarchaeological, isotopic, ancient DNA, paleobotanical, and radiocarbon dating) of a spider monkey sacrificed in the ceremonial center of Teotihuacan, Mexico (1 to 550 CE) is interpreted as a diplomatic gift exchange with neighboring Maya. Not only does this spider monkey provide the earliest known instance of pr...
We propose novel strategies for primate experimentation that are ethically valuable and pragmatically useful for cognitive neuroscience and neuropsychiatric research. Specifically, we propose Natural Laboratory Complex or Natural Labs, which are a combination of indoor-outdoor structures for studying free moving and socially housed primates in natu...
In this paper, we emphasize the importance of studying the primate brain in cognitive neuroscience and suggest a new mind-set in primate experimentation within the boundaries of animal welfare regulations. Specifically, we list the advantages of investigating both genes and neural mechanisms and processes in the emergence of behavioral and cognitiv...
Common marmosets have been widely used in biomedical research for years. Nutritional control is an important factor in managing their health, and insect intake would be beneficial for that purpose because common marmosets frequently feed on insects in natural habitats. Here, we examined the effect of enhanced insect feeding on the gut by analysing...
After a specific point in history, hominin evolution accelerated to a level that could not be accounted for by natural selection alone. An alternative mechanism has been proposed based on mutual interaction among neural, cognitive, and ecological niches in a positive feedback loop (triadic niche construction [TNC]). Nevertheless, the trigger events...
In non-human primates, a subset of frontoparietal neurons (mirror neurons) respond both when an individual executes an action and when it observes another individual performing a similar action.1, 2, 3, 4, 5, 6, 7, 8 Mirror neurons constitute an observation and execution matching system likely involved in others’ actions processing³,⁵,⁹ and in a la...
Despite mirror self-recognition being regarded as a classical indication of self-awareness, little is known about its neural underpinnings. An increasing body of evidence pointing to a role of multimodal somatosensory neurons in self-recognition guided our investigation toward the secondary somatosensory cortex (SII), as we observed single-neuron a...
During primate arboreal locomotion, substrate orientation modifies body axis orientation and biomechanical contribution of fore- and hindlimbs. To characterize the role of cortical oscillations in integrating these locomotor demands, we recorded electrocorticographic activity from left dorsal premotor, primary motor, and supplementary motor cortice...
Recent human imaging studies have revealed the involvement of the secondary somatosensory cortex (SII) in processes that require high-level information integration, such as self-consciousness, social relations, whole body representation, and metaphorical extrapolations. These functions are far beyond its known role in the formation of body maps (ev...
The brain capacity of human ancestors underwent two phase transitions, which were supported by preadaptations during the animal protolanguage period, resulting in the emergence of human language. The transitions were (1) the emergence of the primate cerebral cortex, with its unique characteristic of additional cortical areas together with size expa...
Background: Common marmosets have been widely used in biomedical research for years. Nutritional control is an important factor in managing their health, and insect intake would be beneficial for that purpose because common marmosets frequently feed on insects in natural habitats. However, the effect of insect feeding on the marmoset body has not b...
The topographic map of motor cortical representation, called the motor map, is not invariant, but can be altered by motor learning, neurological injury, and functional recovery from injury. Although much attention has been paid to short-term changes of the motor map, robust measures have not been established. The existing mapping methods are time-c...
Stone-hammering behaviour customarily occurs in Burmese long-tailed macaques, Macaca fascicularis aurea , and in some Burmese-common longtail hybrids, M. f. aurea × M. f. fascicularis ; however, it is not observed in common longtails. Facial pelage discriminates these subspecies, and hybrids express variable patterns. It was tested if stone hammeri...
Understanding the connectivity architecture of entire vertebrate brains is a fundamental but difficult task. Here we present an integrated neuro-histological pipeline as well as a grid-based tracer injection strategy for systematic mesoscale connectivity mapping in the common Marmoset (Callithrix jacchus). Individual brains are sectioned into ~1700...
Songbirds possess mirror neurons (MNs) activating during the perception and execution of specific features of songs. These neurons are located in high vocal center (HVC), a premotor nucleus implicated in song perception, production and learning, making worth to inquire their properties and functions in vocal recognition and imitative learning. By i...
Understanding the connectivity architecture of entire vertebrate brains is a fundamental but difficult task. MRI based methods offer whole brain coverage, but remain indirect in the approach to connectivity mapping. Recent progress has been made in directly mapping whole-brain connectivity architecture in the mouse at the mesoscopic scale. The basi...
As with humans, vocal communication is an important social tool for nonhuman primates. Common marmosets (Callithrix jacchus) often produce whistle-like ‘phee’ calls when they are visually separated from conspecifics. The neural processes specific to phee call perception, however, are largely unknown, despite the possibility that these processes inv...
Objective:
Motor map has been widely used as an indicator of motor skills and learning, cortical injury, plasticity, and functional recovery. Cortical stimulation mapping using epidural electrodes is recently adopted for animal studies. However, several technical limitations still remain. Test-retest reliability of epidural cortical stimulation (E...
We present a new 3D digital brain atlas of the non-human primate, common marmoset monkey (Callithrix jacchus), with MRI and coregistered Nissl histology data. To the best of our knowledge this is the first comprehensive digital 3D brain atlas of the common marmoset having normalized multi-modal data, cortical and sub-cortical segmentation, and in a...
In the plates, Nissl images with (a) or without (a′) structural demarcations and their corresponding MR images (b) are indicated. Reading methods are similar to those in Chap. 2, showing a slicing level by the line on dorsal view of the brain image, stereotaxic coordinates with Horsley-Clarke’s horizontal zero plane, distance from the midline, and...
The common marmoset (Callithrix jacchus), a New World monkey, is increasingly becoming popular world-wide in a variety of biomedical studies as a primate model of human neuro-psychiatric and biological disorders, particularly through gene manipulation technologies. This book provides accurate, comprehensive, and convenient references from combined...
In each plate, Nissl sections with structural demarcations (a) and their corresponding MR images (b) are indicated. Reading methods are similar to those in Chap. 2, showing slicing level by the vertical line on lateral view of the brain image, stereotaxic coordinates with Horsley-Clarke’s horizontal zero plane, distance from the interaural level 0...
Degu (Octodon degus), a rodent native to the Andes Mountains in South America, is commonly known as the trumpet-tailed rat and belongs to the parvorder Caviomorpha along with the chinchilla and guinea pig. As experimental animal models, degus contribute to a variety of medical research fields, for example, those pertaining to diabetes, hyperglycemi...
These are examples of freely cut slices independent from the stereotaxic coordinates but available for the very purpose of slicing.
We present a new 3D digital brain atlas of the non-human primate, common marmoset monkey ( Callithrix jacchus ), with MRI and coregistered Nissl histology data. To the best of our knowledge this is the first comprehensive digital 3D brain atlas of the common marmoset having normalized multi-modal data, cortical and sub-cortical segmentation, and in...
Cortical stimulation mapping is a valuable tool to test the functional organization of the motor cortex in both basic neurophysiology (e.g., elucidating the process of motor plasticity) and clinical practice (e.g., before resecting brain tumors involving the motor cortex). However, compilation of motor maps based on the motor threshold (MT) require...
Key points:
The cortical mechanisms of grasping have been extensively studied in macaques and humans; here, we investigated whether common marmosets could rely on similar mechanisms despite strong differences in hand morphology and grip diversity. We recorded electrocorticographic activity over the sensorimotor cortex of two common marmosets durin...
Tool use is observed and shared in animals with and without phylogenetic relationships. Therefore, tool use is an excellent behavioural model to explore dynamic relationships between animals’ physical and cognitive abilities and their environmental conditions. In this chapter, we will focus on tool use in primates, especially Japanese macaques and...
Background
The common marmoset has been used as an experimental animal for various purposes. Because its average weight ranges from 250 to 500 g, weight loss quickly becomes critical for sick animals. Therefore, effective and non-stressful treatment for chronic diseases, including diarrhoea, is essential.
Case presentation
We report a case in whic...
Brain/MINDS (Brain Mapping by Integrated Neurotechnologies for Disease Studies) is a national brain project started by Japan in 2014. With the goal of developing the common marmoset as a model animal for neuroscience, the project aims to build a multiscale marmoset brain map, develop new technologies for experimentalists, create transgenic lines fo...
Atypical neurodevelopment in autism spectrum disorder is a mystery, defying explanation despite increasing attention. We report on a Japanese macaque that spontaneously exhibited autistic traits, namely, impaired social ability as well as restricted and repetitive behaviors, along with our single-neuron and genomic analyses. Its social ability was...
Previous neurophysiological studies performed in macaque monkeys have revealed complex somatosensory responses in the secondary somatosensory area (SII), such as large receptive fields (RFs), as well as bilateral ones. However, systematic analyses of neurons with large RFs have not been performed. In the present study, we recorded single-unit activ...
Complex motor skills of eventual benefit can be learned after considerable trial and error. What do structural brain changes that accompany such effortful long-term learning tell us about the mechanisms for developing innovative behavior? Using MRI, we monitored brain structure before, during and after four marmosets learnt to use a rake, over a lo...
Experts from a range of disciplines assess the foundations and implications of a novel action-oriented view of cognition.
Cognitive science is experiencing a pragmatic turn away from the traditional representation-centered framework toward a view that focuses on understanding cognition as “enactive.” This enactive view holds that cognition does not...
Cognitive science is experiencing a pragmatic turn away from the traditional representation-centered framework toward a view that focuses on understanding cognition as “enactive.” This enactive view holds that cognition does not produce models of the world but rather subserves action as it is grounded in sensorimotor skills. In this volume, experts...
Despite decades of research, we lack a comprehensive framework to study and explain cognitive development. The emerging “paradigm” of action-based cognition implies that cognitive development is an active rather than a passive, automatic, and self-paced maturational process. Importantly, “active” refers to both sensorimotor activity (in the narrow...
Inappropriate vocal expressions, e.g., vocal tics in Tourette syndrome, severely impact quality of life. Neural mechanisms underlying vocal tics remain unexplored because no established animal model representing the condition exists. We report that unilateral disinhibition of the nucleus accumbens (NAc) generates vocal tics in monkeys. Whole-brain...
Bifidobacterium aesculapii
DSM 26737
T
was isolated from feces of baby common marmoset. Here, we report the draft genome sequence of this organism. This paper is the first published report of the genomic sequence of
B. aesculapii
.
The first draft of the common marmoset (Callithrix jacchus) genome was published by the Marmoset Genome Sequencing and Analysis Consortium. The draft was based on whole-genome shotgun sequencing, and the current assembly version is Callithrix_jacches-3.2.1, but there still exist 187,214 undetermined gap regions and supercontigs and relatively short...
Working memory is used to solve various cognitive problems by maintaining information for some time and then by refreshing this information after certain purposes are achieved. In the present study, we explored the ability of common marmosets to perform a delayed matching to position (DMTP) task in a controlled environment using operant conditionin...
Fig. S1. Phylogenetic tree of mouse (m) or marmoset (cj) coding sequence of each cadherin gene.
Abnormalities in cortico-basal ganglia (CBG) networks can cause a variety of movement disorders ranging from hypokinetic disorders, such as Parkinson's disease (PD), to hyperkinetic conditions, such as Tourette syndrome (TS). Each condition is characterized by distinct patterns of abnormal neural discharge (dysrhythmia) at both the local single-neu...
Japanese macaques are able to learn how to use rakes to take food after only a few weeks of training. Since tool-use training induced rapid morphological changes in some restricted brain areas, this system will be a good model for studying the neural basis of plasticity in human brains. To examine the mechanisms of tool-use associated brain expansi...
Cadherin is a cell adhesion molecule widely expressed in the nervous system. Previously, we analyzed the expression of nine classic cadherins (Cdh4, Cdh6, Cdh7, Cdh8, Cdh9, Cdh10, Cdh11, Cdh12, and Cdh20) and T-cadherin (Cdh13) in the developing postnatal common marmoset (Callithrix jacchus) brain, and found differential expressions between mice an...
Current theories in extended mind suggest that cognition is the result of an integrative process involving brain, body, and environment. The relationships between inner and outer components strictly depend on the functional interface, which is represented by the body. Posture and locomotion influence the sensorial and behavioral relationships betwe...
Previous neurophysiological studies performed in macaque monkeys have shown that the secondary somatosensory cortex (SII) is essentially engaged in the processing of somatosensory information and no other sensory input has been reported. In contrast, recent human brain-imaging studies have revealed the effects of visual and auditory stimuli on SII...
Since the availability of the common marmoset monkey as a primate model in neuroscience research has recently increased, much effort has been made to develop a reliable guide of the brain structures of this species. In this article, we review the development of the marmoset brain atlas and discuss a newly developed brain model, which was reconstruc...
Periostin (POSTN or osteoblast specific factor) is an extracellular matrix protein originally identified as a protein highly expressed in osteoblasts. Recently, periostin has been reported to function in axon regeneration and neuroprotection. In the present study, we focused on periostin function in cortical evolution. We performed a comparative ge...
Although the neural correlates that underlie abdominal pain have been investigated, so-called brain processes involved in modulating "gut feelings" remain unclear. In the current study, we used electrointestinography (EIG) to measure intestinal activity of healthy humans at rest. EIG measured myoelectrical activity of intestinal smooth muscles from...
Song-learning birds and humans share independently evolved similarities in brain pathways for vocal learning that are essential for song and speech and are not found in most other species. Comparisons of brain transcriptomes of song-learning birds and humans relative to vocal nonlearners identified convergent gene expression specializations in spec...
The cerebral cortex is an indispensable region that is involved in higher cognitive function in the mammalian brain, and is particularly evolved in the primate brain. It has been demonstrated that cortical areas are formed by both innate and activity-dependent mechanisms. However, it remains unknown what molecular changes induce cortical expansion...
The middle temporal visual area (MT, also known as V5) is a visual association area that is particularly evolved in the primate brain. The MT receives input from the primary visual area (V1), constitutes part of the dorsal visual pathway, and plays an essential role in processing motion. Connections between the MT and V1 in the primate brain are fo...
Whether animals use relational cues in transposition tests has long been considered a controversial issue. In the present study, we examined whether common marmosets could generalize relational responses to untrained stimulus pairs and further apply these generalizations to unknown shapes. The subjects were trained to perform simple discrimination...
Language is a characteristic feature of human communication. Several familial language impairments have been identified, and candidate genes for language impairments already isolated. Studies comparing expression patterns of these genes in human brain are necessary to further understanding of these genes. However, it is difficult to examine gene ex...
Throughout human history, economic bubbles have formed and burst. As a bubble grows, microeconomic behavior ceases to be constrained by realistic predictions. This contradicts the basic assumption of economics that agents have rational expectations. To examine the neural basis of behavior during bubbles, we performed functional magnetic resonance i...
Primary objective:
To study the mechanism of somatosensory-vestibular interactions, this study examined the effects of somatosensory inputs on body sway induced by galvanic vestibular stimulation (GVS) in healthy participants and persons with brain injury in the posterior insula, a region constituting a part of the parietoinsular vestibular cortex...