February 2022
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Background: It is known that general anesthesia weakens autonomic function and baroreflex control. Intravenous anesthetics may have different qualitative and quantitative effects on the peripheral autonomic nervous system (ANS) and, can thus, alter the activity of sympathetic or parasympathetic divisions of the ANS. Presently, there are relatively little data regarding sex differences in ANS activity or sex differences in ANS activities during anesthesia. The primary goal of the present study was to assess sex differences in ANS activity in dependence on the light-dark (LD) cycle in healthy, sexually mature, spontaneously breathing zoletil-anesthetized rats.