Asiye Uzun’s research while affiliated with Istanbul Medipol University and other places

The human X-box binding protein 1 is a transcription factor that is expressed by cellular oxidative stress. We aimed to analyze the relationship between early pregnancy loss and maternal blood X-box binding protein 1 levels. Patients who presented to our Obstetrics and Gynecology clinic between October 2019 and February 2020 were included in this study. Patients were divided into two groups: Group 1 included healthy pregnant women and Group 2 included patients who were diagnosed with missed abortion. First, blood samples were taken from the patients in group 2 when they were diagnosed with missed abortion. While evaluating the patients in group 1, the average gestational weeks of the patients in group 1 were calculated and blood samples were taken between the same weeks. Next, patients with healthy pregnancy in group 1 were followed up prospectively and double screening test were performed at the perinatology outpatient clinic at the end of the 1st trimester, and the blood results of the patients with normal results were evaluated. Blood samples extracted from these patients were centrifuged at −80 °C and stored until analyses. Serum X-box binding protein 1 levels were measured using enzyme-linked immunosorbent assay kits (Cusabio, Wuhan, China). Eighty-five patients were included in this study: 42 in Group 1 and 43 in Group 2. There was no difference between the groups in terms of age, body mass index, ethnicity, and systemic illness. Serum X-box binding protein 1 levels were significantly higher in Group 2 (129.89 ± 7.58 ng/L) than in Group 1 (119.56 ± 5.99 ng/L) (p < 0.001). Serum X-box binding protein 1 levels higher than the cut-off value of 119.05 ng/L were associated with a higher risk of early pregnancy loss. Serum X-box binding protein 1 levels may be used to predict early pregnancy loss; however, additional comparative studies are required to confirm this result

Objective: Cesarean section (C/S) is one of the most common operation performed by the gynecologist throughout the world. The aim of this study is to present our experience in this particular group of patients and compare the early and late outcomes of the patients with and without a bladder flap after a C/S procedure. Materials and Method: All cases admitted between October 2018 and January 2019 due to C/S were retrieved from hospital electronic medical records. Data were collected on demographics, perioperative test results, operative characteristics, postoperative complications and outcomes. The C/S decision was given by the surgeon per fetal or maternal problems such as placenta previa, ablatio placenta, malpresentation, fetal distress, macrosomia and prolapses of the umbilical cord. Patients were grouped into two as Group 1 comprised patients who had C/S with bladder flap while Group 2 included the patients without bladder flap. Results: There were 63 patients included in the study with a mean age of 27.87 ± 4. None of the patients in either group had bladder injury. The comparison of the groups demonstrated the group were statistically equal in maternal age, weight, body mass index (BMI) and gestational week. The presence of microhematuria was significantly higher in Group 1 patients (p=0.000, OR 2.55, 95% CI 1.568-4.159) and there was statistically significant decrease in the hemoglobin levels (Group 1 0.91 ± 1.48 vs Group 2 0.13 ± 1.24, p=0.026). However, the decrease in the hematocrit values did not statistical significance (Group 1 1.78 ± 6.84 vs Group 2 0.63 ± 4.09, p=0.423). The postoperative residual urine, on the other hand, was slightly higher in patients with bladder flap. Conclusion: Bladder flap during C/S has adverse effects on the blood loss, surgical time and postoperative symptoms. Hence, omitting the flap will improve the postoperative comfort both for the patient and the surgeon.

INTRODUCTION: In this study, it is aimed to evaluate the relationship between urinary tract infection [UTI] and genital hygiene behaviors in any period of life. METHODS: The study is single-center and descriptive. All women agreed to participate in the study from the patients admitted to the Health Sciences University Şişli Hamidiye Etfal Research Hospital Family Practice Clinic any reason is planned to be included in the survey. A questionnaire consisting of 36 questions questioning the participants' socio-demographic and genital hygiene behaviors was applied face to face. RESULTS: 142 patients were included in the study. The average age is 38.5 +- 14.2 (min=18, max=70). It was 104 (%73,2) people who had UTI at any time. There was no relation between socio-demographic features and UTI at any time (p≥0.05). In the questioning of Obstetrics and Gynecology information, there was no relationship between the number of pregnancies, the number of births, the most recent birth type, and currently being in menopause and UTI at any time (p≥0.05), but a relationship with the gynecological operation was found (p=0.038). There was a significant correlation between performing genital area cleaning from the back to the front and transmitting UTI in any period (p=0.041). DISCUSSION AND CONCLUSION: As a result, a relationship was found between performing genital area cleaning from the back to the front, having a gynecological operation, and transmitting UTI at any time in life. We think that organizing the right hygiene education and increase the awareness of society will decrease UTI.

INTRODUCTION: To assess the effects of umbilical cord clamping time on risk of postpartum depression. METHODS: The study included pregnant cases giving birth after 36 weeks from 24 January 2020 to 01 April 2020 in our clinic. Those with previous depression history, chronic disease, multiple pregnancy, puerperant women with impaired hemodynamics after birth, and neonates with poor Apgar score after birth or who required resuscitation were not included. The postpartum umbilical cord clamping time was classified according to the World Health Organization as late 1 minute or more and early under 1 minute. Patients were evaluated in two groups according to this grouping. During the follow-up examination performed in the postpartum 1 month, the risks in terms of postpartum depression were evaluated with the Edinburgh Postpartum Depression Scale given to the patients in the outpatient clinic. RESULTS: The study included 176 pregnant cases with birth after 36 weeks. Both groups were not observed to be different in terms of sociodemographic characteristics, obstetric history and birth information (p≥0,05). In both groups, mean EPDS points were identified as 11.07+-1.97 in the late clamping group and 13.23+-1.61 in the early clamping group and this was statistically significant (OR=6.36; p<0.001). DISCUSSION AND CONCLUSION: With our study results, we identified that cases with late clamping of the umbilical cord had lower risk of postpartum depression