Ashwani Kumar's scientific contributions
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Publication (1)
In 1995, Amidon and coworkers introduced the biopharmaceutical classification system (BCS) to reduce the need for in vivo bioequivalency studies, utilization of in vitro dissolution tests as a surrogate for in vivo bioequivalence studies. The principles of the BCS classification system can be applied to NDA and ANDA approvals as well as to scaleup...
Citations
... В литературных источниках каптоприл иногда относят к классу I (высокая растворимость и высокая проницаемость) по биофармацевтической классификационной системе (БКС) [6]. Однако ряд авторов относят каптоприл к классу III по БКС (высокая растворимость и низкая проницаемость) [7][8][9]. БКС предполагает, что для лекарств с высокой растворимостью и высокой проницаемостью (класс I) и, в некоторых случаях, для лекарств с высокой растворимостью и низкой проницаемостью (класс III) растворение более 85 % за 15 минут может гарантировать, что биодоступность лекарства не ограничена растворением Методы анализа лекарственных средств Analytical Methods субстанции. В этих случаях этапом, лимитирующем скорость всасывания лекарственного средства, является опорожнение желудка. ...