Ashley Sang Eun Lee’s research while affiliated with Icahn School of Medicine at Mount Sinai and other places

... Using a combination of four informative epitopes from ω−5-gliadin and γ-gliadin, BBEA achieved the highest AUC of 0.908, with 83.4% sensitivity and 88.4% specificity. In comparison, wheat-sIgE showed an AUC of 0.646, P < 0.001) [59]. ...

Reference:

Molecular Diagnosis to IgE-mediated Wheat Allergy and Wheat-Dependent Exercise-Induced Anaphylaxis

... They are the "conditions in which people are born, grow, work, live, and age, and the wider set of forces and systems shaping the conditions of daily life." [24] FI and health inequities in food allergy are often a consequence of these systemic SDOH [25,26]. Health equity refers to the achievement of an individual's maximum level of health and well-being irrespective of their social condition, and addressing SDOH is critical to promote health equity. ...

Reference:

Food Insecurity and Health Inequities in Food Allergy

... The most common allergens in acute FPIES include cow's milk, soy, eggs, fish, and cereals [11,12]. However, with recent guidelines endorsing the early introduction of peanuts in early infancy, there has been an increase in peanut-induced FPIES [13]. ...

Reference:

A Review of Non-IgE Immune-Mediated Allergic Disorders of the Gastrointestinal Tract

... This age coincides with the development of dislike of a food, which generally happens around 6-7 years and persists into older age [55]. However, this area requires further study: Lee et al. [56] followed 44 patients (ages 2-13 years, median age 6.5 years, 4 children under age 5) up to 4 years post successful sustained unresponsiveness (SU) challenge to peanut and reported that all were still consuming peanut regularly. ...

Reference:

Oral Immunotherapy Should Play a Key Role in Preschool Food Allergy Management

... Mutations in MTHFD1 could result in the occurrence of severe combined immunodeficiency. 61 The expression of MTHFD1L was upregulated in colon cancer cells treated with anti-PD-1 nivolumab, which promoted the proliferation of cancer cells. 39 In addition, MTHFD2 upregulation was positively related to mast cell activation and NK cell resting in head and neck squamous cell carcinoma, which is an immune-related metabolic enzyme. ...

Reference:

Targeting one‐carbon metabolism for cancer immunotherapy

... The prevalence of FA has increased worldwide in the last 20 years, particularly in Westernized developed countries [8]. The estimation of the prevalence of FA is conditioned by lots of factors such as the intrinsic characteristics of individuals (i.e., age, gender, ethnicity, genetics), geographical setting (i.e., urban and metropolitan areas vs. rural ones, the presence of air pollution, different climatic zones with different vegetation and pollen distribution, various available foods), dietary habits or practices (i.e., usual foods, the custom of cooking foods and cooking method used, breastfeeding duration and age of weaning and introduction of solid food, dietary fat), socioeconomic and racial disparities (i.e., different awareness of food allergy, inequality of health care access and utilization, availability and use of drugs or diet supplementation) and the methodology used for diagnosis [9][10][11][12][13][14][15][16][17][18]. The high number of combinations of these factors in the various geographical areas justifies the wide heterogeneity of the worldwide prevalence of FA which ranges from a minimum of 0.14% reported in India [19] to a maximum of 37.8% reported in Europe [9,10,20]. ...

Reference:

Worldwide Heterogeneity of Food Allergy: Focus on Peach Allergy in Southern Italy

... Several methods were used to detect allergen specific antibodies: The first applied technique is synthetic peptide array technology assay membrane, which is now less utilized due to its inability to quantify epitope binding, the high volume of patient serum required, and the membrane's limit on number of epitope-IgE interactions [32]. Another method is capture ELISA which is useful for IgE detection to whole protein or epitope peptides, but not well standardized and time-consuming [33]. ...

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Genetic, Inflammatory and Immunological Biomarkers for the Early Assessment of Allergic Asthma: A Current Update

... K. pneumonia osteomyelitis affects multiple sites, with widespread destruction and periosteal reaction, and cranial osteomyelitis caused by K. pneumoniae is very rare. 14, 15 We do not know the capsular serotype of our isolates because typing is not available at our institution. Highly virulent and hyperviscosity Klebsiella pneumoniae (hvKP) strains can cause severe invasive infections such as osteomyelitis of the femur. ...

Reference:

A Case of Severe Chronic Multifocal Osteomyelitis of the Skull Caused by Klebsiella pneumoniae in Mali

... Several studies, ranging from case reports and single-center cases to extensive multicenter cohort studies, have explored the impact of COVID-19 and SARS-CoV-2 infection on patients with known IEIs [16][17][18][19][20][21][22][23][24][25][26][27]. These studies commonly report the severity of SARS-CoV-2 infection in IEI patients. ...

Reference:

Human Genetic and Immunological Determinants of SARS-CoV-2 Infection and Multisystem Inflammatory Syndrome in Children