Arun Kumar Prabhakar's research while affiliated with Nanyang Technological University and other places

Publications (4)

Article
The cover represents the dual molecular encapsulation using natural pine pollen, as described in article number 1800151 by Eijiro Miyako, Nam‐Joon Cho and coworkers. By simple vacuum and passive loading methods, they demonstrate that diverse molecules are binary encapsulated into the pollen microcapsule. In addition, the loaded molecules can be eff...
Article
Full-text available
Pine pollen offers an all-natural multi-cavity structure with dual hollow air-sacs providing ample cargo capacity available for compound loading. However, the pollen exhibits reduced permeability due to the presence of a thin natural water-proofing layer of lipidic compounds. Herein, we explore the potential for compound loading within pine pollen...
Article
Full-text available
The loading of multiple drugs into a single carrier is an effective advanced clinical therapeutic for various diseases. Here, by exploiting the architectural features of natural pine pollen from Pinus massoniana, the spatially controlled encapsulation of two types of molecules in distinct compartments of a single microparticulate carrier is demonst...
Article
Full-text available
Pine pollen is widely used in traditional Chinese medicine and has been consumed as a food product for thousands of years. Owing to wind pollination, its pollen grains are composed of a sporoplasmic central cavity along with two empty air sac compartments. While this architectural configuration is evolutionarily optimized for wind dispersal, such f...

Citations

... This new quantitative characterization of the bissacate pollen wall is important for applications, for example, pollen has been considered a natural possibility for drug encapsulation for some time now and pine pollen has recently been used for testing of this application (37). The nanofoam structure may also inform studies that consider pollen as a model material used to fabricate and inspire biomimetic materials (21,38,39). ...
... Currently, single-drug loading is struggling to meet treatment needs due to the complexity of the human body and the internal environment [23][24][25]. It is of great significance to fabricate DDSs loaded with multiple drugs, especially the sequential release of different drugs, to enhance the treatment efficacy [26][27][28][29]. It has been reported that the sequential release of doxorubicin (DOX) and bromodomain-containing protein 4 inhibitor (BRD4i) JQ1 remarkably inhibited growth and suppressed lung metastasis of 4T1 breast tumor [30]. ...
... 6 Being a chemically highly inert and ubiquitous biopolymer, 7 the SEC is suitable for applications such as medical imaging, the delivery of pharmaceuticals and other active substances, 6 heavy metal removal, catalyst support, and taste suppression. 2 The loading efficiencies for drug delivery applications were investigated in several SECs such as pine, 8 date palm, 9 Corylus avellane, 10 dandelion, 11 plane tree, 12 and Lycopodium clavatum. 13,14 Pollen grains are renewable materials and abundant in nature. ...