Arne Burkhardt's research while affiliated with University of Tuebingen and other places
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Publications (24)
In der 1.Auflage des Bandes 4 aus dem Jahr 1969 waren unter topographisch-anatomischen Gesichtspunkten vier Organregionen — Nase und Nasennebenhöhlen, Kehlkopf and Luftröhre, Schilddrüse, Mediastinum — abgehandelt worden, wobei der Schwerpunkt der Darstellung das Mediastinum betraf. Das damals von K. KÖHN gestaltete Kapitel umfaßte sowohl den Kehlk...
The spectrum of conventional and advanced morphological methods for the assessment of malignant potential of precancerous lesions of the laryngeal mucosa is discussed.
Cancer, if not in essence a genetic disease, is at least to a large extent determined in its behaviour by the interaction of a number of genetically coded products, which may enhance its growth (oncogenes) or suppress it (tumour suppressor genes or anti-oncogenes). However, the genetic changes of various cancers show considerable individual variati...
Tissue markers of potential malignancy have been sought for many years. Cell surface markers, particularly blood group and histocompatibility antigens, have shown great promise and several squamous carcinoma antigens have been identified--but not fully studied in potentially malignant lesions. Growth factors and receptors also need further study. C...
"Alveolitis", as opposed to "pneumonia" sensu strictiori, is a term used to denote diffuse inflammatory changes of the pulmonary parenchyma, excluding those that result from local bacterial, fungal or other extracellular microbial growth. The various types of alveolitis are classified according to their histological characteristics and range from "...
Most malignant neoplasms of the larynx and the adjacent regions (hypopharynx and oropharynx with lingual epiglottic surface, valleculae, lower part of the retrolingual region) are squamous cell carcinomas (Table 5.1). In a survey of 1207 patients with malignant tumours of the larynx treated in the Frankfurt University Ear, Nose and Throat Clinic be...
Von Albertini (1974) defined true neoplasms as ?irreversible autonomic overgrowths of the body?s tissue?. Autonomic growth excesses are, in part, also represented by those frequent hyperplasias which occur in the larynx, namely, tissue growth as a result of inflammation, polyps and cysts. These so-called pseudotumours must be separated from the irr...
The incidence of malignant neoplasms of the larynx has risen in proportion to the increase in new cases of respiratory tract carcinomas in general (MC– MICHAEL 1978, STEINER 1984; review KLEINSASSER 1983); the overall mortality is 2.5 per 100000 person–years, and in the USA new laryngeal cancers form 1.5% of all new cases of cancer and laryngeal ca...
Verrucous carcinoma was first described as a separate entity by ACKERMAN (1948) and is also termed ACKERMAN tumour. ACKERMAN described 31 such tumours that had arisen in the oral cavity. All were in elderly patients with poor oral hygiene and badly fitting dental prostheses who often chewed plug tobacco.
As already defined in Chap. 3, pseudotumours, just like neoplasms, are tissue overgrowths. However, in contrast to true neoplasms, pseudotumours usually regress after elimination of the inflammatory or mechanical–functional causes, i.e. they are reversible in the broadest sense. Pseudotumours at an early stage exhibit the same signs and symptoms as...
To make a tentative diagnosis, as a rule indirect laryngoscopy using a forehead mirror and a laryngeal mirror in the course of an initial ENT examination suffices. Better diagnostic results can be obtained, however, with a magnifying laryngoscope such as that described byVON STUCKRAD and LAKATOS (1975). In all patients with suspected carcinoma of t...
Our knowledge of the embryonal development of the larynx has been supplemented by recent studies using the Carnegie system of staging (TUCKER and O’RAHILLY 1972,O’RAHILLY 1973, O’RAHILLY and BOYDEN 1973, O’RAHILLY and TUCKER 1973); this system divides the development of the human embryo into 23 stages which correlate with the appearance of certain...
The histological preparation of whole larynges in the form of multiple serial sections is made considerably more difficult by the difference in hardness of the various tissue types in this organ, and in particular by the age-dependent ossification of cartilaginous parts of the skeleton. The detailed knowledge regarding the spread of endolaryngeal t...
Large lung sections of humans of advanced adult age revealed a markedly nonuniform retention pattern of dense anthracotic particle aggregates, with an impressive accumulation of this material along pulmonary lymphatics, i.e. the deep (peribronchial), septal (perivenous) and superficial (pleural) networks. Conversely, the alveolar parenchyme contain...
The pathology and classification of brain tumors has been dealt with in previous chapters. If one attempts to group brain tumors into clinicopathological entities to provide guidance for therapeutic decisions as well as for comparisons of treatment results, simplifications, omissions and generalizations have to be made. It may therefore be pudent t...
Gute oder beste Ergebnisse können bei der Krebsbehandlung nicht mehr im Alleingang eines Spezialisten, sei er Chirurg, Strahlentherapeut oder internistischer Onkologe, erreicht werden. Das Schicksal des Tumorkranken entscheidet sich meistens bei der ersten Maßnahme, welche die Beseitigung der Geschwulst zum Ziel hat. Das gilt besonders bei der Ther...
Citations
... However, larger expanding margins can bring greater radiation damage to normal tissues and organs and also limit the increase in dosage in PTV. 6 To effectively reduce positioning errors in stepwise radiotherapy, a study revealed that thermoplastic film somatic fixation was more accurate than other fixation methods. 7 At the same time, to more accurately measure the positioning errors, for both accurately measuring positioning errors and reducing damage to normal tissues, cone beam computed tomography (CBCT) is superior to the electronic portal imaging device (EPID). ...
... In addition to this local TRP-serotonergic effect on the GIT, TRP may increase GIT functionality indirectly through its inhibitory effect on the peripheral sympathetic nervous system. It is well known that stress and a general stimulation of the sympathetic nervous system lead to a reduction in both GIT blood flow [40][41][42] and digestion and in an increase of intestinal fluid secretion and defecation [13,[43][44][45]. The increase in N-digestion and/or N-absorption by surplus dietary TRP may therefore be caused by both serotonergic driven mechanisms and by inhibition of stress hormone kinetics. ...
... Such pattern was called muddle formation by Sabarth and Williams [ Figure 2]. [6,7] The pattern of crystallization in the control group was that of an eccentrically placed center of gravity with orderly arranged needles radiating from center toward periphery [ Figure 3]. ...
... Heppleston's 1956 publication (5) seems to have been the first to suggest that the airspace dilation seen with honeycombing results from alveolar collapse that produces locally exaggerated traction during inhalation in adjacent lung. Spencer (6) and subsequently numerous other investigators (2,4,(7)(8)(9)(10) proposed that the damage to alveolar lining cells that occurs in pulmonary fibrosis reduces surfactant, thereby increasing the tendency for alveoli to collapse. ...
... In its early stages, ALI/ARDS manifests as acute/diffuse damage to the lung parenchyma (endothelial/epithelial lining of the terminal respiratory unit) and severe exacerbation of the host defense response (HDR). Its progression depends on disruption of the basement membrane, alterations in vascular permeability, exudation of fluid from the alveoli, and the degree of the initial pulmonary HDR [222][223][224][225][226]. ...
... 9 Along this route, the particles may accumulate in the peribronchiolar area, especially within lymphoid aggregates, and in the subpleural area. 10 In our study, the particles were seen in peribronchiolar and subpleural areas in all cases. The study revealed no difference in the location of BP deposition among individual disease groups or the controls. ...
... Several HSPs (Heat Shock Protein) are implicated in the prognosis of specific cancers, for example, HSP70 expression predicts predicts the response to chemotherapy in osteosarcomas. 9. Recurrence and second primary tumour P53 expression may be a significant tumour marker for diagnosing the risk of recurrence of primary disease as well as second primary tumours of head and neck SCC [42][43][44][45][46] 10. Odontogenic tumours Cytokeratins-CK 14 and 19 are frequently expressed in odontogenic tumours with epithelial origin 47,48 . ...
Reference: An overview of tumour marker in oral cancer
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... 13,17 Leukoplakia comprises several histological features: benign, premalignant, and malignant lesions. 18 Benign leukoplakia is usually a limited and often reversible lesion, which can be controlled with follow-up or removed with transoral microsurgery. Differently, malignant leukoplakia lesions require immediate biopsy and, in some cases, radiotherapy or transoral laser surgery to prevent recurrence. ...
