Aresatz Usobiaga's research while affiliated with Universidad del País Vasco / Euskal Herriko Unibertsitatea and other places

... For the same reason, using the ionic gelation process, Taghiloo, S. et al. developed sodium alginate and chitosan nanoparticles that contained Echinacea angustifolia extract to increase their stability and prolong their release [40]. Using the vibration microencapsulation nozzle technique, Villate, A. et al. synthetized chitosancoated alginate microcapsules, which contained Cannabis raw extract, to obtain an edible pharmaceutical-grade product [41]. In contrast, our study used microencapsulation technology to ensure the release of the RG plant extract into the intestine, minimizing the effect of acidic pH on the bioactivity of the compounds. ...

... Oxybenzone poses a threat to crop yield for a variety of crops, regardless of whether the cultivation systems use hydroponic methods, irrigation using R1 water (recycled waters from sewage/waste waters treatment facilities), or amended soils human or livestock biosolids (Cabrera-Peralta and Peña-Alvarez, 2018;Ramos et al., 2021;Gautam et al., 2022). By understanding the homeostatic and metabolic processes susceptible to oxybenzone toxicity, we can select for genotypic markers that can give these susceptible crops an advantage against the ubiquitous exposure to oxybenzone (Villate et al., 2021). A multi-array 'omics' approach is being used to successfully accelerate the selection and cultivation of stress tolerant plants (Razzaq et al., 2019;Tahir ul Qamar et al., 2020;Pandey et al., 2021;Zhang et al., 2022). ...

... After that GC-MS is conveyed for the examination of cannabinol, cannabidiol, and different constituents of cannabis. [67] Narcotics and psychoactive drugs are identified from human urination and plasma samples which are separated by SUPRAS (Supramolecular Solvent) method. It is a valuable method in clinical and criminological cases in narcotics and psychoactive drug misuse. ...

... Stir bar sorptive extraction (SBSE) was first described by Baltussen in 1999 [75]. The method was proposed as a solvent-free sample enrichment technique that combines extraction and preconcentration of the target analytes. ...

... ( Fig. S3), was identified in the samples examined herein. This substance is known as an antioxidant and stabilizer in polymers employed in food manufacturing [61], and is widely used to prevent free-radical-mediated oxidation in fluids (e.g., fuels and oils) and other materials [62]. It is reported that 2,6-di-tert-butyl-4-ethylphenol not only hinders the survival and reproduction of aquatic organisms, but also endangers human health [63,64]. ...

... Regarding the extraction step, most of the protocols developed for multiresidue trace determination of pharmaceuticals in fish are based on ACN or MeOH as extraction solvents [11,21], with a predominant use of neutral [22,33,34] and acidified solvents [26,27,35]. However, to the best of our knowledge, basified solvents have not yet been systematically evaluated and applied for this purpose in the literature. ...

... Furthermore, fatty acids were down-regulated in the LT-28d samples, whereas, triglyceride was up-regulated, suggesting triglyceride accumulation in the liver and subsequently an increase in intrahepatic lipids. Lipid alterations in fish have been associated with xenobiotic exposure, including carbendazim (Ezeoyili et Sakr & Shalaby, 2014;Ziarrusta et al., 2018). A study carried out on adult zebrafish showed that carbendazim exposure affected glycolipid metabolism and detoxification metabolism in the liver (Bao et al., 2020). ...

... Other resin sorbents studies for detecting pharmaceutical and pesticides in river and ground water, have used Strata-X using a nylon Membrane and mixed Polymer Sampler (MPS) [248][249][250][251]. A copolymer of poly(divinylbenzene)-N-vinylpyrrolidone was used as resin sorbent for monitoring 46 pesticides, 17 pharmaceuticals and some artificial sweeteners [252]. ...

... The quantification of the investigated pharmaceuticals in various sample forms was carried out using a variety of analytical techniques, such as spectrofluorimetry [6,7], highperformance liquid chromatography (HPLC) [8][9][10][11], and liquid chromatography coupled to a mass spectrometric detector (LC-MS/MS) [12,13]. The extensive usage of FQs in recent years has raised concerns for people since they have a detrimental impact on them. ...

... Modulation of the endocannabinoid system by targeting G-protein-coupled cannabinoid receptors has broad therapeutic applications ranging from pain to cancer treatment [27,28]. A series of oxazolo [5,4-d]pyrimidines (22) were designed via the bioisosterism strategy as new cannabinoid receptor 1 (CB 1 R) and cannabinoid receptor 2 (CB 2 R) modulators ( Figure 5) [29]. ...