Aqu Alu's research while affiliated with Sichuan University and other places

... Ibrutinib was the first BTKi authorized by the FDA in 2013 [15]. In 2021, ibrutinib overtook the sales of all other cancer drugs to become the world's fourth best-selling medication [79]. Ibrutinib is used to treat CLL, small lymphocytic lymphoma (SLL), Waldenström's macroglobulinemia (WM), marginal zone lymphoma, and graft-versus-host ...

... We directly connected the RBD subunits of the beta variant with the HR subdomain formed to the trimeric protein, which could trigger strong immune response against Omicron variants and maintain a stable natural trimer conformation. Several studies have shown that polymer protein vaccines may elicit more desirable immune responses than vaccines comprised of monomeric antigens [18,30,31]. Notably, RBD β -HR/trimer protein was constructed by the baculovirus-insect cell expression system, which was extensively utilized to yield RBD [32], glycosylated S1 domain [33], S protein [34], SARS-CoV-2 virus-like particles [35], and so on. ...

... Shaharabani et al. noted that myelin phase transition increases with sodium concentrations > 150 millimoles per liter (mmol/L), which is within the range found in vivo [40]. For example, normal serum sodium levels in rodents and humans are approximately 140 mmol/L, but higher sodium concentrations in lymphoid and interstitial tissue range from 160 to 250 mmol/L sodium [48]. Of relevance, serum sodium concentrations are sensitive to fluid overload in hypervolemia, and clinical hyponatremia should be classified as hypervolemic, hypovolemic, or euvolemic [49]. ...

... For production of large amounts of TRM cells, Bosnjak et al. utilized a prime-boost protocol on a novel modified vaccinia virus Ankara (MVA)-SARS-2-spike vaccine candidate to induce immune responses, which alleviated weight loss, increased clinical score, and decreased viral titers in rodents (98). Furthermore, Lei et al. developed a recombinant RBD vaccine against variants of concern for intranasal administration, which not only induced and maintained high IgG levels, but also enhanced mucosal immunity, including lung TRM cells (99). In particular, humoral immunity and TRM cells attained by intranasally delivered SARS-CoV−2 DNA vaccine efficiently suppresses the wild type and Beta variant, providing persistent protection (100). ...

... Among the various laboratory findings observed in COVID-19 [12,48,50,51], several studies focused on extracellular traps of both neutrophils and monocytes (ETs) [52][53][54], which have now emerged as diagnostic and prognostic biomarkers COVID-19, since they are actively involved in both cytokine storm and coagulation dysfunctions [55][56][57]. As recently overviewed by Ligi et al. [58], extracellular histones (released as unmodified and/or citrullinated proteins from inflammatory activated leukocytes, in particular circulating monocytes) have gained momentum due to their well-known role in fostering organ injuries and systemic diseases [59,60], thus emerging as reliable diagnostic and/or prognostic markers of ETosis in SARS-CoV-2 infection [3,52,53,61], due to their active role in COVID-19 related immunothrombosis and thromboinflammation [56] which are main causes of severe illness [45,62]. Interestingly, early identification in COVID-19 of hyperhistonemia, which has been associated with higher mortality risk [46,63], will predictably provide novel unexpected insights on whether circulating histone monitoring may be helpful in patients with SARS-CoV-2 infection [45]. ...

... Intranasal vaccine is administered into each nostril using a manufacturer-filled nasal sprayer; the only vaccine administered this way is one formulation of the live attenuated influenza vaccine [75]. Intranasal delivery of COVID vaccines of different platforms including virus-vectored vaccines, recombinant subunit vaccines, and live attenuated vaccines are in the development stages and potentially move to the clinical setting [76]. ...

... Among them, bio-based materials are mainly derived from cells, bacteria, and viruses, such as protein-based nano systems and outer membrane vesicles. In addition, according to their sources, biomaterials can be divided into natural and synthetic materials (Han et al., 2022). Natural biomaterials have been utilized for a long time due to their superior biocompatibility, biodegradability, low toxicity, and hypoallergenic, and the degradation products yielded are less cytotoxic, thus metabolized more easily by host tissues Han et al., 2022). ...

... In addition, pancreatic cystic lesions have been categorized using radiomics methods in multiple studies [332,333]. Although these findings confirmed the feasibility of radiomics for the assessment of pancreatic cystic lesions [334][335][336][337][338][339][340][341][342][343][344], the robustness of these radiomics diagnostic models may be limited due to the relatively small datasets included in most studies. Therefore, the accumulation of additional research data is required for the study of pancreatic cystic lesions. ...

... The binding capacity of the SP of SARS-CoV-2 that emerged in Wuhan city (2019) displayed 10 to 20 times more affinity toward hACE2R than the virus that occurred in 2002. 4 The WHO introduced the term "Variant of Concern" (VOC) to recognize the viral variants with mutations in their SP, which changed the binding affinity to the hACE2R. 5 The VOCs include Alpha acquired a strong affinity and binding capacity to hACE2R, resulting in higher transmissibility. ...

... In addition, polymers such as chitosan [228] and polyethyleneimine (PEI) [229,230] exhibit potential as mucosal adjuvants due to their delivery capacity and immunostimulatory effects. For instance, Lei et al. investigated three cationic nanocarriers, chitosan, N-[1-(2,3-Dioleoyloxy) propyl]-N,N,Ntrimethylammonium chloride (DOTAP) and PEI, and showed them to be effective adjuvants for the SARS-CoV-2 recombinant RBD vaccine by intranasal or intramuscular immunization [231]. Similarly, the safety of these adjuvants must be a concern of utmost importance. ...