Anupam Nagpal’s scientific contributions

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Publications (13)


Oral Manifestations Due to Nutritional Deficiencies & Systemic Diseases : A Review
  • Article
  • Full-text available

May 2019

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6,610 Reads

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Anuradha Garg

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Anupam Nagpal

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Biomedical Waste Management: A Review

May 2019

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13,108 Reads

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1 Citation

As a result of economic development in industrial, infrastructure, medical, information technology and agriculture sector in India in the past 20 years, the citizens have become more content, lavish and comfortable but this has also affected the environment badly because of tremendous increase in environmental pollution as the rate of waste generation is very high in India. Waste product which is infectious, hazardous, and sometimes radioactive and is generated during the various medical related activities such as diagnosis, treatment and immunization is known as biomedical waste. Today, biomedical waste management has become one of major issue of concern in India taking into account the rate of growth of population and rapid urbanization. This paper includes biomedical waste, its classification and various practices adopted for its management. Biomedical waste may be solid or liquid and is generated majorly from hospitals and laboratories. Biomedical waste include discarded blood samples, sharps, unwanted microbiological cultures, identifiable body parts other human or animal tissue, used bandages and dressings, discarded gloves, other medical supplies that may have been in contact with blood and body fluids, and laboratory waste that exhibits the similar characteristics. Biomedical waste is distinct from normal trash or general waste. Medical facilities also generate hazardous chemicals and radioactive materials. While such wastes are normally not infectious; but they require proper disposal. Disposal of this waste is also an environmental concern, as many medical wastes are classified as infectious and could potentially lead to the spread of infectious disease. Biomedical waste must be properly managed and disposed of to protect the environment, general public and workers, especially healthcare and sanitation workers who are at risk of exposure to biomedical waste as an occupational hazard. Steps in the management of biomedical waste include generation, accumulation, handling, storage, treatment, transport and disposal.


Irritational Fibroma – A Case Report

May 2019

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2,438 Reads

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3 Citations

Chronic irritational factors like plaque, calculus, overhanging margins, trauma and dental appliances are the major causes for reactive hyperplastic growths seen in the oral cavity. This paper reports a case of irritation fibroma in a 40-year-old female in relation to gingiva of 12, 13, 14 region. Excisional biopsy was done and diagnosis of irritational fibroma was rendered on the basis of histopathological evaluation.


ORAL CYSTICERCOSIS: A RARE DIFFERENTIAL DIAGNOSIS FOR ORAL SWELLINGS

November 2018

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90 Reads

International Journal of Advanced Research

Cysticercosis is a major public health problem worldwide particularly in developing countries. It is a potentially fatal helminthic disease commonly seen in India, Southern Africa, Latin America and Eastern Europe which results from infection with the larval stage of the tapeworm, Taeniasolium. It is a condition in which human beings act as the intermediate host of T. solium, the pork tapeworm. It can occur in any site of body but oral lesions are rare. As oral cysticercosis is a rare entity; it is a diagnostic challenge to the oral healthcare professionals and is also poorly documented in the scientific literature. Here, we report a case of oral cysticercosis affecting tongue that emphasizes the importance of subjecting even apparently innocuous appearing lesions for histopathological evaluation and routine microscopic examination in diagnosing such lesions.



Fig. 2A (H & E, 40X) shows dense infiltration immunohistochemical examination in certain
Chronic Sclerosing Sialadenitis : An Under Recognized Entity for Salivary Gland Swellings

April 2017

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1,150 Reads

Chronic sclerosing sialadenitis which is also known as Kuttner tumor is an uncommon chronic, benign, inflammatory lesion, involving submandibular salivary glands mostly. Clinically, it affects middle aged individuals majorly and presents as a firm to hard mass. Histologically, lobular architecture of the salivary gland is well preserved with thickening of interlobular septa by sclerotic tissue and preservation of ducts and periductal fibrosis. It is also characterized by dense lymphoplasmacytic infiltrate and variable loss of acini. This article discusses in detail about chronic sclerosing sialadenitis and this lesion should be considered in the differential diagnosis for salivary gland swellings.


Fig 1: Clone theory: necessary positional information to produce theory suggests that all tooth primordia are A) The molar clone ectomesenchyme has different classes of teeth from inception. initially equivalent, with the individual
Fig 2: Migrating neural crest cells express the epithelium. 
Fig 3: Homeobox code model for dental epithelium to ectomesenchyme and develop; whereas Dlx-1 and Dlx-2 are 1 
Fig 4: Schematic representation explains the
Mechanism of Patterning of Dentition: A Review

November 2016

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3,501 Reads

Patterning of dentition means the determination of tooth types at their correct positions in the jaws. This is a complex process for which various theories have been proposed. Recent studies showed that this process involves expression of various genes. This article presents a systematic review on patterning of dentition.


Granulomatous Diseases affecting Oral Cavity

July 2016

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229 Reads

“Oral Health is a mirror to Systemic Health” Of late, most health care providers overwhelmingly accept the concept that oral health is intimately related to systemic health. It is a well-known fact that some systemic diseases have oral manifestations and that local oral disease may be related to an underlying systemic disorder. Recognizing that oral lesions may be the initial presenting sign during early stages of systemic disease may allow more efficient diagnosis of that underlying disorder. Under the umbrella of such systemic disorders with oral presentation is the increasingly recognized entity characterized by persistent and/or recurrent labial enlargement, oral ulcers and a variety of other oro-facial features called as “Granulomatous Lesions”.


Figure 1: H & E section showing Reed Sternberg Cells (marked with arrow)  
Figure 3: Microscopic picture of Nodular Lymphocyte Predominant HL showing popcorn cells (marked with arrow)  
Figure 4: Microscopic picture of Nodular Sclerosing HL showing nodular pattern with bands of collagenous tissue that surround the nodules & characteristic lacunar cells (marked with arrows)  
Hodgkin’s Lymphoma: A comprehensive review for oral health care practitioners

June 2016

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8,601 Reads

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2 Citations

The proliferative disorders of lymphoid cells may be reactive or neoplastic. Among the neoplastic lymphoid diseases, the distinction between leukemias and lymphomas is merely in the general tissue distribution of the disease with varying and mixed presentations at times. The broad group of lymphomas has been segregated into two types – Hodgkin’s and Non Hodgkin lymphoma. This differentiation is of great importance as each type is clinically and histologically different and unique from each other. Further, they are treated differently and hence of utmost practical importance. This article gives an overview of the Hodgkin’s lymphoma, discussing its classification, clinical and histological features and various treatment modalities.


Ameloblast: An Enigmatic Cell in Enamel Formation

April 2016

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57 Reads

Formation of teeth is a complex process involving many cells and biochemical interactions. Tooth is made up of both hard and soft tissues derived ectodermally and ectomesenchymally. Enamel is the hardest tissue of the human body, forming the outermost covering of the crown of all deciduous and permanent dentition. It is also the only ectodermally derived structure of the tooth, formed by the ameloblast cells of the enamel organ of the tooth bud. Ameloblasts are unique cells in that they not only help in the synthesis of the organic matrix of enamel but also aid in its removal making way for deposition of minerals during its maturation. Once their functions are over, these cells cease and hence are not seen in fully formed teeth.


Citations (2)


... Treatment options involve the traditional surgical approach, the use of soft tissue lasers, cryosurgery, or electrosurgery. 10 The most common form of treatment is surgical enucleation with a scalpel, which involves the total excision of the lesion with safety margins during the surgical process. Intraoperative bleeding control, the need for suturing, and the possibility of postoperative edema are all disadvantages of traditional knife surgery. ...

Reference:

Excision of Traumatic Fibroma of the Tongue in a Pediatric Patient: A Case Report
Irritational Fibroma – A Case Report

... Similarly, T-cell and putative Natural killercell neoplasms were sub-divided into Precursor T-cell neoplasm and Peripheral T-cell and NK-cell neoplasms (10). Murphy and Ann arbor staging schema stages lymphoma based on the number of lymph nodes or single extranodal organ or site involved (12). French-American-British/LMB system is specifically designed for classification of B-cell non-hodgkin lymphoma (13). ...

Hodgkin’s Lymphoma: A comprehensive review for oral health care practitioners