António Cunha’s research while affiliated with University of Minho and other places

Histopathological analysis is an essential exam for detecting various types of cancer. The process is traditionally time-consuming and laborious. Taking advantage of deep learning models, assisting the pathologist in the diagnosis process is possible. In this work, a study was carried out based on the DenseNet neural network. It consisted of changing its architecture through combinations of Transformer and MBConv blocks to investigate its impact on classifying histopathological images of penile cancer. Due to the limited number of samples in this dataset, pre-training is performed on another larger lung and colon cancer histopathological image dataset. Various combinations of these architectural components were systematically evaluated to compare their performance. The results indicate significant improvements in feature representation, demonstrating the effectiveness of these combined elements resulting in an F1-Score of up to 95.78%. Its diagnostic performance confirms the importance of deep learning techniques in men’s health.

Magnetic resonance imaging (MRI) is a non-invasive technique used in cardiac diagnosis. Using it, specialists can measure the masses and volumes of the right ventricle (RV), left ventricular cavity (LVC), and myocardium (MYO). Segmenting these structures is an important step before this measurement. However, this process can be laborious and error-prone when done manually. This paper proposes a multi-stage method for cardiac segmentation in short-axis MRI based on fully convolutional networks (FCNs). This automatic method comprises three main stages: (1) the extraction of a region of interest (ROI); (2) MYO and LVC segmentation using a proposed FCN called EAIS-Net; and (3) the RV segmentation using another proposed FCN called IRAX-Net. The proposed method was tested with the ACDC and M&Ms datasets. The main evaluation metrics are end-diastolic (ED) and end-systolic (ES) Dice. For the ACDC dataset, the Dice results (ED and ES, respectively) are 0.960 and 0.904 for the LVC, 0.880 and 0.892 for the MYO, and 0.910 and 0.860 for the RV. For the M&Ms dataset, the ED and ES Dices are 0.861 and 0.805 for the LVC, 0.733 and 0.759 for the MYO, and 0.721 and 0.694 for the RV. These results confirm the feasibility of the proposed method.

The early and accurate diagnosis of brain tumors is critical for effective treatment planning, with Magnetic Resonance Imaging (MRI) serving as a key tool in the non-invasive examination of such conditions. Despite the advancements in Computer-Aided Diagnosis (CADx) systems powered by deep learning, the challenge of accurately classifying brain tumors from MRI scans persists due to the high variability of tumor appearances and the subtlety of early-stage manifestations. This work introduces a novel adaptation of the EfficientNetv2 architecture, enhanced with Global Attention Mechanism (GAM) and Efficient Channel Attention (ECA), aimed at overcoming these hurdles. This enhancement not only amplifies the model’s ability to focus on salient features within complex MRI images but also significantly improves the classification accuracy of brain tumors. Our approach distinguishes itself by meticulously integrating attention mechanisms that systematically enhance feature extraction, thereby achieving superior performance in detecting a broad spectrum of brain tumors. Demonstrated through extensive experiments on a large public dataset, our model achieves an exceptional high-test accuracy of 99.76%, setting a new benchmark in MRI-based brain tumor classification. Moreover, the incorporation of Grad-CAM visualization techniques sheds light on the model’s decision-making process, offering transparent and interpretable insights that are invaluable for clinical assessment. By addressing the limitations inherent in previous models, this study not only advances the field of medical imaging analysis but also highlights the pivotal role of attention mechanisms in enhancing the interpretability and accuracy of deep learning models for brain tumor diagnosis. This research sets the stage for advanced CADx systems, enhancing patient care and treatment outcomes.