Antonio Bosco's research while affiliated with University of Trieste and other places

... The reduction of white cell blood count is a common side effect of DMDs (Dinoto, 2022) and, in particular, neutropenia, defined as a reduction of the absolute neutrophil count (ANC) below 1.5 × 10 9 /L, may seldom occur during treatment with CD20 depleting drugs. The time of onset from last infusion defines early onset (<4 weeks, EON) and late onset (>4 weeks, LON) neutropenia. ...

... Identification and treatment of relapses recommendations are shown in Table 4. Previous studies have shown the usefulness of telemedicine for the identification of relapses during the beginning of the COVID-19 pandemic [52]. On the other hand, recommendations for the identification of relapses using telemedicine were also published during the pandemic [14,53,54]. ...

... The persistent endocrine and autonomic disturbances are likely due to gray matter (GM) lesion in the hypothalamus or brainstem nuclei that could disturb the hypothalamuspituitary-adrenal axis and descending neural control of the autonomic nervous system [19]. Indeed, the autonomic nervous system dysfunction in patients with MS appears involved in the exacerbation of the symptom of fatigue [19][20][21][22][23]. Dinoto et al. [24] reported a strong correlation between fatigue and autonomic nervous system dysfunction in patients with MS. Specifically, they found that patients with fatigue had a significantly higher dysautonomia compared to patients without fatigue. ...

... Spasticity is a clinically meaningful condition in over 80% of people with multiple sclerosis (MS), and significantly affects quality of life [1,2]. Botulinum toxin (BT) injections safely and effectively treat spasticity by temporarily blocking neuromuscular junctions, thus, favoring the patients' and caregivers' possibilities to exploit residual function and improve the outcome of rehabilitation treatments [3][4][5][6][7]. Clinical trials are generally run in a limited time frame (i.e., response at 4-12 weeks) and include a variety of neurological conditions, thus, limiting the analysis of disease-specific features. ...

... This rapid movement, accompanied by uncontrollable inhalation, causes the epiglottis to suddenly close the respiratory tract, thus making a short, loud sound [12,13]. Intractable hiccup refers to the case that the spasm persists for more than 48 h, which can lead to laceration of the test tube at the cardia part and the gastric fundus mucosa as the disease progresses, reducing the safety of chemotherapy [14,15]. Baclofen, a gamma-aminobutyric acid (GABA)-derived organism, inhibits the release of excitatory amino acids by exciting GABA-β receptor, thereby reducing the reflex potentials at single or multiple synapses in the spinal cord and between the posterior roots of the spinal cord, thereby playing a role in relaxing the skeletal muscle and relieving spasm [16,17]. ...

... In our study, a possible explanation for the improvements in physical activity and walking speed might be that tele-yoga may help by altering various factors such as reducing stress or tension in muscles, improving mobility, blood circulation, and flexibility in joints and tendons in female patients with MS, and also that the tele-Pilates exercise protocol improves functional factors such as balance, strength, and stability to enhance muscle capability and tolerability. In addition, improving muscle control through appropriate intra-and intermuscular contractions appears to be one of the major determinants of reduced walking speed in PwMS [73]. ...

... 2 Moreover, in more advanced disease, neurodegeneration may occur in the absence of neuroinflammation. 3 Indeed, neuronal and axonal loss are major pathological features of irreversible and progressive MS 4 accompanied by progressive brain atrophy and ventricular enlargement. 5 However, the accuracy of automated brain volumetric assessment has been questioned, 6 with the demonstration of hypertrophy of the putamen 7 and an increase in brain volume in 26.3% of longitudinal scans. 8 There has been considerable interest in evaluating surrogate markers of neurodegeneration to monitor and predict disease progression, and as endpoints in trials of neuroprotection in MS. 9 Optical coherence tomography (OCT) has been used to show retinal nerve fibre layer (RNFL) thinning in MS and has been related to the severity of axonal damage in the visual pathways 10 and brain atrophy. ...

... Bi- laterality was slightly more (16%) than in the literature (12%) and MS was more frequent (5.5%) than in the literature (2%) likely related to overrepresentation of women in the sample. Women are more likely to have MS and MS is the most common (18%) known cause of bilateral trigeminal neuralgia [13,14]. Aside from this, the demographics and clinical features of our patients are in line with the literature indicating that even though they were not consecutive patients-impossible to obtain the low cost and novel method employed-they truly repre- sent most TN patients. ...

... Les bolus de corticoïdes effectués pour le traitement des poussées peuvent déclencher des manifestations transitoires d'anxiété ou plus rarement des poussées psychotiques. Bosco et al. (1999) n'ont retrouvé sur 1527 cures de méthylprednisolone administrées que 3 % d'arrêt de traitement ; moins de 1 % était du à une cause psychopathologique. ...

... This figure is significantly higher in patients with chronic diseases [32] and in women with MS (40-74%) [33]. Moreover, although several studies in the literature highlight the correlation between multiple sclerosis and sexual dysfunction, a solution to this problem, which is underestimated and poorly studied by medical professionals and usually not spontaneously reported by the patient because of feelings of embarrassment, is still to be sought [34]. ...