Antonella Tosti’s research while affiliated with University of Miami and other places

What is this page?


This page lists works of an author who doesn't have a ResearchGate profile or hasn't added the works to their profile yet. It is automatically generated from public (personal) data to further our legitimate goal of comprehensive and accurate scientific recordkeeping. If you are this author and want this page removed, please let us know.

Publications (194)


Efficacy, safety and tolerability of drugs for alopecia: a comprehensive review
  • Literature Review

February 2025

·

8 Reads

Jair Alejandro Valdez-Zertuche

·

Hassiel Aurelio Ramírez-Marín

·

Antonella Tosti

Clinical Practices and Educational Interests of Dermatologists in Caribbean Countries

January 2025

British Journal of Dermatology

This manuscript holds particular significance for a global health and equity dermatology journal as it addresses critical considerations for continuing medical education and relevant epidemiology of the Caribbean. Our survey’s aim was to determine the perspective and needs of Caribbean dermatologists to better support this community. Our focus was to identify common conditions seen in clinical practice and the educational interests of the group. We hope our data helps guide local and international efforts to identify and address the needs of this diverse and unique region.


Videodermoscopy as a Diagnostic Tool for Pili Trianguli and Canaliculi Syndrome

December 2024

·

6 Reads

Pediatric Dermatology

·

·

Jacopo Tartaglia

·

[...]

·

Luca Mariano

Pili trianguli et canaliculi syndrome is a rare hair shaft disorder characterized by frizzy hair that cannot be smoothed flat. Affected hair shafts are triangular or kidney‐shaped with longitudinal grooving. Diagnosis typically requires electron microscopy, which may be cost‐prohibitive, or alternatively, the distinctive features of hair shafts can be identified through histological examination of cross sections, that is time‐consuming. To overcome these challenges, we describe a novel videodermoscopy technique as a cost‐effective and simple alternative, suitable for outpatient settings.


Low-Dose Oral Minoxidil Initiation for Patients With Hair Loss: An International Modified Delphi Consensus Statement

November 2024

·

159 Reads

Importance The results of small studies suggest that off-label use of low-dose oral minoxidil (LDOM) may be safe and effective for patients with hair loss, but larger trials and standardized guidelines are lacking. Objective To create an expert consensus statement for LDOM prescribing for patients with hair loss. Evidence Review The current literature on the pharmacological properties, adverse effect profile, and use of LDOM for patients with hair loss was reviewed. Topics of interest were identified, and a modified Delphi consensus process was created. A total of 43 hair loss specialist dermatologists from 12 countries participated in a modified Delphi process. Consensus was reached if at least 70% agreed or strongly agreed on a 5-point Likert scale. Findings Over 4 survey rounds, 180 items in the first round, 121 items in the second round, 16 items in the third round, and 11 items in the fourth round were considered and revised. A total of 76 items achieved consensus including diagnoses for which LDOM may provide direct or supportive benefit, indications for LDOM compared to topical minoxidil, dosing for adults (18 years and older) and adolescents (aged 12 to 17 years), contraindications, precautions, baseline evaluation, monitoring, adjunctive therapy, and specialty consultation. Pediatric use and dosing items for children younger than 12 years, and LDOM titration protocols fell short of consensus. Conclusions and Relevance This international expert consensus statement regarding the off-label prescribing of LDOM for patients with hair loss can help guide clinical practice until more data emerge. Hair loss experts with experience treating pediatric patients were underrepresented on this expert panel. Future research should investigate best practices for LDOM use in pediatric patients. Other critical topics for further investigation include the comparative efficacy of topical minoxidil vs oral minoxidil, the safety of oral minoxidil for patients with a history of allergic contact dermatitis to topical minoxidil, the long-term safety of LDOM, and the use of other off-label forms of minoxidil, such as compounded formulations of oral minoxidil and sublingual minoxidil. As additional evidence-based data emerge, these recommendations should be updated.


Teletrichology for Hair Disorder Consultations

November 2024

·

1 Read

The COVID-19 pandemic brought novel challenges to the practice of dermatology, including the remote clinical management of hair and scalp disorders. This chapter explores teledermatology for hair and scalp disorders, where we define teletrichology as the use of telecommunication platforms to interact with hair disorder patients remotely. We use the term to encompass triaging, consultations, remote imaging, and diagnoses (Randolph et al. in J Eur Acad Dermatol Venereol, 2020 [1]). The chapter assesses the nature of patient consultations and methods of evaluation of ailments in teledermatology, the benefits and challenges of teletrichology, and proposes triaging methods for efficient patient management. Finally, given that these remote consultations that arose due to the COVID-19 will likely endure and be integrated into routine practice, we offer policy and practical recommendations to improve patient outcomes.


Role of Autologous Micrografting Technology through Rigenera ® System in the Treatment of Androgenetic Alopecia

October 2024

·

4 Reads

Skin Appendage Disorders

Introduction: Androgenetic alopecia (AGA) is a common form of baldness, affecting 60–70% of the adult population worldwide, and may have a negative effect on quality life. AGA leads to a progressive thinning of scalp hair and is characterized by a progressive miniaturization of the hair follicle with a specific pattern distribution. Although AGA is a very frequent condition, compelling therapeutic options are still limited. Methods: Herein, we present the protocol of autologous micrografting technology through Rigenera® system allowing to obtain a suspension of autologous micrografts ready to be injected on scalp. This paper combines the results of two studies that evaluated the effects of micrografts in patients with AGA. The first study involved 17 patients who received one micrografts session with a 6-month follow-up. The second study 13 patients who received two micrografts sessions 6 months apart with a follow-up of 6 months after the second session. Clinical assessment involved global photography evaluation and patient’s satisfaction before and after the treatment. Hair measures using TrichoLab were also performed. Results: Most of the patients had a moderate improvement after investigator’s assessment in terms of hair loss reduction and hair density improvement. The assessment of patients was satisfactory in terms of hair improvement and treatment tolerability. Conclusion: In summary, we conclude that this new regenerative approach can be a promising tool for clinicians to obtain a viable, sterile and ready to use micrografts that can be immediately injected into the scalp to improve AGA condition.




Advances in image-based diagnosis of nail disorders

September 2024

·

44 Reads

·

2 Citations

Journal of the European Academy of Dermatology and Venereology

This paper provides a comprehensive overview of image‐based techniques, particularly focusing on their applications and advancements in the context of nail disorders. Nowadays, high‐resolution digital cameras and dermoscopes enable dermatologists to capture detailed images of nail abnormalities, facilitating early diagnosis and meticulous tracking of disease progression. Onychoscopy is now a routine technique with well‐known criteria for the diagnosis, but recent developments allow us to visualize certain diseases better. Imaging modalities like high‐frequency ultrasound, magnetic resonance imaging, optical coherence tomography and confocal microscopy are being increasingly adopted for their superior diagnostic capabilities. These techniques are described in their technology, scanning protocols, normal findings, advantages and limitations. Moreover, the integration of technology in patient education has fostered a more informed patient population, capable of actively participating in their disease monitoring and treatment regimens. Proper training, validation, regulation and ethical considerations are, however, essential when integrating technology into healthcare practices. Imaging technologies that present the potential to add critical anatomical information to clinical diagnoses within reasonable costs and are available worldwide are the ones that will probably be used the most.



Citations (58)


... The higher the number of Tesla units, the higher the axial spatial resolution. For this reason, MRIs operating at 3.0 Tesla, although not specifically dedicated to small areas, are often those advisable for nails [45]. ...

Reference:

Diagnosis and Management of Malignant Epithelial Nail Unit Tumors
Advances in image-based diagnosis of nail disorders
  • Citing Article
  • September 2024

Journal of the European Academy of Dermatology and Venereology

... A cross-sectional analysis using the FDA Adverse Events Reporting System identified monoclonal antibodies as a major drug class implicated in AA, with adalimumab and dupilumab ranking among the top drugs associated with this condition [61]. Among the chemotherapeutic agents implicated in drug-induced alopecia are included docetaxel and capecitabine [62]. ...

A cross-sectional analysis of medications used by patients reporting alopecia areata on the FDA adverse events reporting system
  • Citing Article
  • January 2024

International Journal of Dermatology

... An additional problem is the resistance currently being recorded in regard to the treatment involving dermatophytes with terbinafine, either for clinical reasons specific to the patient (such as diabetes) or for microbiological reasons, such as acquired resistance due to previous exposure to the drug. In other words, failure can be due to empirical prescription without diagnostic confirmation using a complementary test in patients who did not have onychomycosis before or who had been impacted by another pathogen [45][46][47]. Thus, it is important to confirm the diagnosis via a complementary test before prescribing appropriate antifungal drugs [21,46]. ...

Treatment of onychomycosis in an era of antifungal resistance: Role for antifungal stewardship and topical antifungal agents
  • Citing Article
  • January 2024

Mycoses

... A signal was detected for hypertrichosis only with the highest dose range (≤10 mg) ( Table 1). The signal for hypertrichosis is dose-dependent and is consistent with previous reports [21,22]. Sanabria et al. found that hypertrichosis is significantly more common at younger ages [23]; our study also supports this finding. ...

Low-Dose Oral Minoxidil for Alopecia: A Comprehensive Review
  • Citing Article
  • Full-text available
  • September 2023

Skin Appendage Disorders

... 1,3,6 Trichoscopy and Reflectance Confocal Microscopy (RCM) have been employed to assess hair damage and severity of Chemotherapy-Induced Alopecia (CIA), and recently both techniques were also used to investigate patients with HHIs-induced alopecia, identifying subclinical features similar to those observed in alopecia areata and CIA. 3,7 Line-field Confocal Optical Coherence Tomography (LC-OCT) is a new imaging technique able to provides in-vivo morphological assessment of skin lesions, with a quasi-histological resolution. 8,9 Upgrowing literature data supports its valuable role in the non-invasive diagnosis of skin cancers and inflammatory skin conditions, and preliminary findings have also been reported for hair loss in different diseases of the scalp. ...

Trichoscopic Patterns and Confocal Microscopy Features of Chemotherapy-Induced Alopecia

Skin Appendage Disorders

... 5 The similar increasing dose-response relationship in both scalp hair and eyebrow/eyelash hair regrowth has been reported with another AA treatment drug, baricitinib. [17][18][19] Considering these observations, the improvement in both scalp and eyebrow/eyelash hair loss in AA patients may require modulation of similar immunoregulatory cytokines. In line with this, a higher proportion of AA patients with abnormal eyebrow and eyelash has been observed in patients with higher baseline SALT based on the B7981015 data (data not shown) as well as baricitinib clinical trials. ...

42146 Concurrent improvement in scalp hair and eyebrow or eyelash regrowth in patients with severe alopecia areata treated with baricitinib
  • Citing Article
  • September 2023

Journal of the American Academy of Dermatology

... Having in mind that these people suffered from a variety of different dermatological conditions (atopic dermatitis, psoriasis, acne, etc.) and were not exposed to hemp-based products only by topical application but also by oral administration and inhalation, it can be concluded that the amount of clinical evidence is still limited. Further randomized, controlled studies need to be conducted [68]. ...

Cannabinoids for the Treatment of Hair, Scalp, and Skin Disorders: A Systematic Review

Cosmetics

... BTXA injections have shown promising results in the adjunctive treatment of FFA including its pathogenic scalp hyperhidrosis [43] and progressive inflammatory hair loss by attenuating production of proinflammatory cytokines and increasing blood flow to the hair follicle dermal papilla [44,45]. While repetitive BTXA injections of the forehead have been associated with an FFA-like frontal hairline recession in a few case reports [46,47], trichoscopy is inconsistent with characteristic FFA trichoscopic findings and this association has yet to be confirmed by larger studies. ...

Botulinum Toxin for Scalp Conditions: A Systematic Review
  • Citing Article
  • August 2023

Dermatologic Surgery

... The variability in pathogen distribution is influenced by climatic, geographical and migratory factors. Mixed infections, nondermatophytes, and yeasts are more prevalent than previously recognized, particularly in warmer climates [24,25]. Nonetheless, our findings are consistent with those from an earlier study in Beijing, which reported a high occurrence of T. rubrum (43/49) and T. interdigitale (4/49) in onychomycosis cases, likely due to the relatively cold, dry conditions of northern China. ...

Onychomycosis: Old and New

Journal of Fungi