Anthony H. Wheeler’s scientific contributions

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Publications (1)


Botulinum Toxin A, Adjunctive Therapy for Refractory Headaches Associated With Pericranial Muscle Tension
  • Article

July 1998

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14 Reads

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156 Citations

Headache The Journal of Head and Face Pain

Anthony H. Wheeler

Pericranial muscle tension may contribute to the development of facial discomfort, chronic daily headache, and migraine-type headache. Elimination of pericranial muscle tension may reduce associated myalgia and counteract influences that can trigger secondary headaches which fall within the migraine continuum. Four patients with chronic, predominantly tension-type headaches and associated pericranial muscle tension failed prolonged conventional treatment and, therefore, symptomatic areas were treated with botulinum toxin A. This alleviated myalgia and reduced the severity and frequency of migraine-type headaches with a concomitant reduction in subsequent medical and physical therapy interventions. Judicious use of botulinum toxin A into defined areas of pericranial muscle tension may be useful for reducing primary myalgia and secondary headache.

Citations (1)


... BT-A may be considered as an option in the prophylactic treatment of TTH [53]. The thought mechanism of BT-A in TTH is the reduction in pericranial muscle tension by cholinergic chemodenervation [54], inhibition of calcium-dependent CGRP from trigeminal neurons, and inhibition of pain mediators such as substance P, bradykinin, and glutamate by degradation of SNAP-25 [55,56]. ...

Reference:

Non-Migraine Head Pain and Botulinum Toxin
Botulinum Toxin A, Adjunctive Therapy for Refractory Headaches Associated With Pericranial Muscle Tension
  • Citing Article
  • July 1998

Headache The Journal of Head and Face Pain